Solubility of β-carotene and co-solutes in supercritical carbon dioxide for ternary systems: Experimental data and correlation

Zúñiga‐Moreno, Abel; Arenas-Quevedo, Miguel G.; Elizalde-Solis, Octavio

doi:10.1016/j.supflu.2019.03.005

Cited by 11 publications

(7 citation statements)

References 45 publications

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“…Knowing the solubility of pharmaceuticals in SC carbon dioxide is highly required for industrializing the SC-CO 2 -based processes . Solubility data not only can help to optimize the process yield, rate, design, and cost but also, knowing the drug solubility, can help the researchers to pre-evaluate the important characteristics of the drug particles, including size, surface structure, and morphology of products. − In light of these facts and requirements, the solubility of different substances in SC-CO 2 has been measured under different pressures and temperatures during the past two decades. − …”

Section: Introductionmentioning

confidence: 99%

Experimental Solubility Measurements of Fenoprofen in Supercritical Carbon Dioxide

et al. 2020

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In the current investigation, the solubility of fenoprofen as a nonsteroidal anti-inflammatory drug in supercritical CO2 (SC-CO2) is measured by employing a motorized PVT (pressure–volume–temperature) equilibrium cell. The solubility measurements were carried out in temperatures between 308 and 338 K and pressures between 12 and 40 MPa. The measured data reveals that the solubility of fenoprofen (mole fraction) lies between 2.01 × 10–5 and 4.20 × 10–3, depending on the thermodynamic conditions. Besides the experimental measurement of fenoprofen solubility, thermodynamic modeling of solubility using five different density-based semi-empirical correlations was carried out. The models were considered with only three fitting parameters, namely, Mendez-Santiago and Teja (MST), Bartle et al., Kumar and Johnston (K–J), Chrastil, and Garlapati and Madras models. The results revealed that among the examined models, the Bartle et al. model was the most accurate one with the lowest average absolute relative deviation percent (AARD %) of 6.58% for the studied drug, while the K–J model leads to poor prediction with an AARD % of 9.60%.

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Section: Introductionmentioning

confidence: 99%

Experimental Solubility Measurements of Fenoprofen in Supercritical Carbon Dioxide

et al. 2020

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“…With respect to these requirements, it seems that CO 2 is the most applicable choice for SCF-based technologies in the light of its mild critical conditions (e.g., temperature and pressure of 304.13 K and 7.3 MPa, respectively), especially in pharmaceutical industries as they deal with compounds which are highly sensitive to temperature and mostly degraded at temperatures higher than 323 or 333 K. Also, CO 2 is a favorable solvent because it is readily available, nontoxic, nonflammable, and cheap, making it the best candidate for different SCF-based processes. With respect to the aforementioned facts, shortcomings, and progresses, solubility of different solids including pharmaceuticals and nonpharmaceuticals in SC-CO 2 was measured by different researchers during the past twenty years. − …”

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Loxoprofen Solubility in Supercritical Carbon Dioxide: Experimental and Modeling Approaches

et al. 2020

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The solubility of loxoprofen as a nonsteroidal anti-inflammatory drug (NSAID) is measured at various temperatures (308, 318, 328, and 338 K) and pressures (12,16,20,24,28,32,36, and 40 MPa) in supercritical carbon dioxide (SC-CO 2 ). The solubility data were measured using a gravimetric-based approach and revealed the solubility range of 1.35 × 10 −5 to 1.28 × 10 −3 based on the mole fraction of loxoprofen. The results revealed that solubility can be significantly enhanced from 1.04 × 10 −5 to 1.28 × 10 −3 (mole fraction basis) for the isotherm at 338 K because of the effect of temperature which can boost the pressure effect on solubility enhancement, at pressures greater than crossover (around 20 MPa for the case of loxoprofen). Moreover, the experimental data points were modeled using five different density-based correlations including Chrastil, Garlapati and Madras, Mendez-Santiago and Teja (MST), Bartle et al., and Kumar and Johnston (K−J) models because measuring the solubility of loxoprofen in entire required ranges of pressure and temperature is impossible or expensive similar to the other pharmaceuticals. The results of modeling revealed that one can correlate the loxoprofen solubility data with an accuracy of about 9.2% (Mendez-Santiago−Teja), 10.7% (Bartle et al.), 7.1% (Kumar and Johnstone), 12.7% (Chrastil), and 12.7% (Garlapati and Madras) based on average absolute relative deviation percent (AARD %).

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“…The supercritical fluid applications dealt with mass transfer applications. The solubility of solutes in ScCO 2 is one of the important physical property data in the process. , In the light of this fact, several studies have investigated the effect of different parameters on the solubility of different compounds and reported the experimental measured solubility of the compounds using different dynamic or static methods. − …”

Section: Introductionmentioning

confidence: 99%

Experimental Determination and Association Model for the Solubility of Laminarin in Supercritical Carbon Dioxide

et al. 2020

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Laminarin is a kind of polysaccharide extracted from kelp, which has immunomodulatory, anti-tumor, hypoglycemic, and antioxidation effects. Laminarin extraction from kelp and encapsulation with polymers in supercritical carbon dioxide (ScCO 2 ) are a green and efficient process. The solubilities of laminarin in ScCO 2 are one of basic parameters in the process. By using the method of dynamic and static combination, the solubilities of laminarin in ScCO 2 with or without the ethanol as a cosolvent were measured under the temperatures of 308.15, 313.15, and 318.15 K and the pressures from 10.0 to 16.0 MPa. The effects of the operating parameters including the pressure, temperature, and content of a cosolvent on the solubility of laminarin in ScCO 2 were investigated experimentally. The solubilities obtained from the experiments were correlated by using Chrastil, Meńdez-Santiago Teja (M-S T), Del Valle and Aguilera (D-A), Bartle, Thakur-Gupta (T-G), and M-Mendez-Santiago-Teja-Thakur-G (M-MST-TG) models, respectively. The results showed that the calculated values by the models fitted were in good agreement with the experimental ones. The average absolute relative deviations (AARD (%)) without a cosolvent were 4.

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Solubility of β-carotene and co-solutes in supercritical carbon dioxide for ternary systems: Experimental data and correlation

Cited by 11 publications

References 45 publications

Experimental Solubility Measurements of Fenoprofen in Supercritical Carbon Dioxide

Experimental Solubility Measurements of Fenoprofen in Supercritical Carbon Dioxide

Loxoprofen Solubility in Supercritical Carbon Dioxide: Experimental and Modeling Approaches

Experimental Determination and Association Model for the Solubility of Laminarin in Supercritical Carbon Dioxide

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