Solubility, solubility parameters and solution thermodynamics of thymoquinone in different mono solvents

Ahmad, Ajaz; Raish, Mohammad; Alkharfy, Khalid M.; Alsarra, Ibrahim A.; Khan, A; Ahad, Abdul; Jan, Basit L.

doi:10.1016/j.molliq.2018.10.104

Cited by 38 publications

(41 citation statements)

References 33 publications

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“…The correlation between the x e and x Apl values of PPD was conducted in terms of “root mean square deviations ( RMSD ) and the coefficient of determination ( R 2 )”. The RMSD values of PPD were estimated by applying its standard equation, as reported in the literature [31,32].…”

Section: Resultsmentioning

confidence: 99%

“…The results of the “Δ sol G 0 values” for the PPD dissolution were in accordance with the recorded solubility data of PPD. The estimated positive values of “Δ sol H 0 and Δ sol G 0 ” in twelve pharmaceutical solvents suggested an “endothermic dissolution” of PPD in all of the studied pharmaceutical solvents [32].…”

Section: Resultsmentioning

confidence: 99%

“…The recorded positive “Δ sol S 0 values” for the PPD dissolution suggested an “entropy-driven dissolution” of PPD in all of the studied pharmaceutical solvents [25]. Finally, the dissolution of PPD was obtained as being “endothermic and entropy-driven” in all of the studied pharmaceutical solvents [25,32].…”

Section: Resultsmentioning

confidence: 99%

“…The 2θ range for obtaining these patterns was set at 3−80°, with a scan speed of 0.5° min −1 . The rest of the conditions and procedures were the same as those reported for the PXRD analysis of luteolin and thymoquinone in the literature [31,32].…”

Section: Methodsmentioning

confidence: 99%

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Synthesis, Characterization and Solubility Determination of 6-Phenyl-pyridazin-3(2H)-one in Different Pharmaceutical Solvents

et al. 2019

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The current research work proposed the solubility data and solution thermodynamic properties of the cardiovascular agent 6-phenylpyridazin-3(2H)-one [PPD] in twelve pharmaceutical solvents at “T = 298.2 K to 318.2 K” and “p = 0.1 MPa”. The measured solubilities of PPD were regressed well with “van’t Hoff and Apelblat models”. The solid phases of pure and equilibrated PPD were characterized using differential scanning calorimetry and powder X-ray differactometry, and the results suggested no transformation of PPD into solvates/hydrates/polymorphs after equilibrium. The solubilities of PPD in a mole fraction at “T = 318.2 K” were noted at a maximum in dimethyl sulfoxide (DMSO, 4.73 × 10−1), followed by polyethylene glycol-400 (PEG-400, 4.12 × 10−1), Transcutol® (3.46 × 10−1), ethyl acetate (EA, 81 × 10−2), 2-butanol (2.18 × 10−2), 1-butanol (2.11 × 10−2), propylene glycol (PG, 1.50 × 10−2), isopropyl alcohol (IPA, 1.44 × 10−2), ethylene glycol (EG, 1.27 × 10−2), ethanol (8.22 × 10−3), methanol (5.18 × 10−3) and water (1.26 × 10−5). Similar tendencies were also noted at other studied temperatures. The results of the “apparent thermodynamic analysis” showed an endothermic and entropy-driven dissolution of PPD in all pharmaceutical solvents. The results of the activity coefficients suggested a maximum interaction at the molecular level in PPD-DMSO, PPD-PEG-400 and PPD-Transcutol, compared with other combination of the solute and solvents.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Synthesis, Characterization and Solubility Determination of 6-Phenyl-pyridazin-3(2H)-one in Different Pharmaceutical Solvents

et al. 2019

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“…Mole fraction solubility of AHF in three different room temperature ionic liquids (BMMHFP, HMMHFP, and OMMHFP), transcutol-HP, and water was determined by shake flask method [29,30]. The solubility of AHF in these solvents was measured at T = 298.2 K, 303.2 K, 308.2 K, 313.2 K, and 318.2 K under atmospheric pressure.…”

Section: Methodsmentioning

confidence: 99%

Estimating the Solubility, Solution Thermodynamics, and Molecular Interaction of Aliskiren Hemifumarate in Alkylimidazolium Based Ionic Liquids

et al. 2019

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Estimating the solubility and solution thermodynamics parameters of aliskiren hemifumarate (AHF) in three different room temperature ionic liquids (RTILs), Transcutol-HP (THP) and water are interesting as there is no solubility data available in the literature. In the current study, the solubility and solution thermodynamics of AHF in three different RTILs, THP and water at the temperature range from 298.2 to 318.2 K under air pressure 0.1 MP were evaluated. The solid phase evaluation by Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction (PXRD) indicated no conversion of AHF into polymorph. The mole fraction solubility of AHF was found to be highest in 1-hexyl-3-methylimidazolium hexafluorophosphate (HMMHFP) ionic liquid (7.46 × 10−2) at 318.2 K. The obtained solubility values of AHF was regressed by the Apelblat and van’t Hoff models with overall root mean square deviations (RMSD) of 0.62% and 1.42%, respectively. The ideal solubility of AHF was higher compared to experimental solubility values at different temperatures. The lowest activity coefficient was found in HMMHFP, which confirmed highest molecular interaction between AHF–HMMHFP. The estimated thermodynamic parameters confirmed endothermic and entropy driven dissolution of AHF in different RTILs, THP, and water.

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Anticancer effects of thymoquinone in head and neck squamous cell carcinoma: A scoping review

Kwan,

Han,

Mukdad

et al. 2023

Laryngoscope Investig Oto

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ObjectiveThymoquinone (TQ), the active constituent of Nigella sativa, has been shown to have anticancer effects in head and neck squamous cell carcinoma (HNSCC). This review aims to outline the properties of TQ, the known drivers in HNSCC formation, and summarize the anticancer effects of TQ in SCC.Data SourcesThree databases (PubMed, Embase, and Google Scholar) were queried for the key words “thymoquinone squamous cell carcinoma.”Review MethodsPublications that were not original research and publications that did not have full‐text available for review were excluded.ResultsSixteen research articles met the inclusion criteria. Our review demonstrates that TQ‐induced cytotoxicity is associated with increased expression and activity of the tumor suppressor p53, proapoptotic proteins Bax and caspases, as well as decreased expression and activity of antiapoptotic proteins Bcl‐2 and Mdm2. Additionally, TQ modulates cell‐survival pathways such as the PI3k/Akt pathway. TQ synergizes with therapeutics including cisplatin and radiation. Early TQ administration may prevent carcinogenesis via upregulation of antioxidant enzymes, and TQ administration in the presence of cancer can result in disease mitigation via induction of oxidative stress.ConclusionTQ acts as an upregulator of proapoptotic pathways and downregulator of antiapoptotic pathways, modulates the oxidative stress balance in tumor development, and works synergistically alongside other chemotherapeutics to increase cytotoxicity. TQ has the potential to prevent carcinogenesis in patients who are at high‐risk for SCC and adjuvant treatment for SCC patients undergoing conventional treatments. Future studies should aim to identify specific populations in which TQ's effects would be the most beneficial.Level of EvidenceNot available.

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Solubility, solubility parameters and solution thermodynamics of thymoquinone in different mono solvents

Cited by 38 publications

References 33 publications

Synthesis, Characterization and Solubility Determination of 6-Phenyl-pyridazin-3(2H)-one in Different Pharmaceutical Solvents

Synthesis, Characterization and Solubility Determination of 6-Phenyl-pyridazin-3(2H)-one in Different Pharmaceutical Solvents

Estimating the Solubility, Solution Thermodynamics, and Molecular Interaction of Aliskiren Hemifumarate in Alkylimidazolium Based Ionic Liquids

Anticancer effects of thymoquinone in head and neck squamous cell carcinoma: A scoping review

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