Solubilization and extraction of curcumin from Curcuma Longa using green, sustainable, and food-approved surfactant-free microemulsions

Effect of hydrophobically modified PEO polymers (PEO-dodecyl) on oil/water microemulsion properties: in vitro and in silico investigations

“…[5][6][7] In addition, microemulsions are the subject of many potential applications in detergents, 8 lubrication, 9 phytosanitary, 10 cosmetics, 11 formulation of paints, 12 and advanced petrol extraction. 13 This growing interest in microemulsions also results from a better understanding of their physicochemical properties. [14][15][16][17] The interfacial lm formed by the surfactant molecules is characterized by its tension, its rigidity, and its spontaneous curvature.…”

“…[22][23][24][25] Although there are still few products on the market, microemulsions exhibit remarkable properties, in particular an ultralow water/oil interfacial tension 26,27 and a high solubilizing power both towards hydrophilic and lipophilic compounds. 28,29 Compared to a conventional emulsion, a microemulsion is a better vector for the active agents because it consists of nanodroplets that allow better penetration of these active agents. [30][31][32] It also has the advantage of being prepared cold, [33][34][35] which on the one hand reduces energy consumption during its preparation, and on the other hand, it uses heat-sensitive active ingredients.…”

Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin

“…The plant occurs naturally throughout many tropical and subtropical regions of the world and has been used in Ayurveda and traditional Chinese medicine for thousands of years to treat inflammatory disease(s) and bacterial infection(s) [ 32 , 33 ]. Since the first reported extraction and separation of CUR around 1815, novel, facile, efficient and sophisticated extraction procedures continue to be developed [ 26 , 34 , 35 , 36 ]. The most commonly reported extraction method for CUR from turmeric makes use of solvent extraction procedures followed by column chromatography.…”

Curcumin Extraction, Isolation, Quantification and Its Application in Functional Foods: A Review With a Focus on Immune Enhancement Activities and COVID-19

“…Kwon and Chung ( 143 ) showed that subcritical solvent extraction provided a maximum yield of 13.58% at 135°C/5 min with water/ethanol mixture (50:50, v/v) as a solvent whereas the Zhou et al ( 149 ) reported the optimization of microwave-assisted extraction of curcuminoids from Curcuma longa using 69% ethanol, 21:1 liquid:solid ratio and microwave time of 55 s with a yield of 28.97 mg/g rhizomes powder. Among different modern extraction processes, enzyme-assisted ionic liquid extraction and surfactant-free microemulsion (SFME) extraction achieved a yield of 5.73 and 0.76–2.94%, respectively ( 128 , 140 ). Water used as a solvent in the subcritical extraction process has reduced the toxicity of the organic solvent and serves as a strong substitute for the organic solvent since it is safe and easily available ( 137 , 143 ).…”

“…Despite many drawbacks such as high temperatures, high operating times, and high organic solvent use, the traditional extraction method is commonly used due to its simple procedures and low operating costs (127,135,136). Identification and quantification of bioactive compounds are accompanied by the use of one or more chromatography techniques such as thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), and ultra-HPLC with a mass spectrometer (MS) (66,(136)(137)(138)(139)(140). Sample preparation is a basic step followed prior to the extraction of the desired bioactive compound.…”