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Salting-in or salting-out tendencies depend on a balance between headgroup-specific ion effects and the hydrophobicity of the tail.

The sugar alcohol meglumine enhances the solubility of organic compounds in water and enforces the formation of electron donor–acceptor (EDA) complexes, enabling photochemical C−C and C−S cross‐coupling transformations without sensitizers. The light‐driven redox‐neutral protocol connects haloarenes with indoles, anilines, anisoles, and thiols, as reported by Burkhard König and co‐workers in their Research Article (e202218775).

The amino alcohol meglumine solubilizes organic compounds in water and enforces the formation of electron donor acceptor (EDA) complexes of haloarenes with indoles, anilines, anisoles or thiols, which are not observed in organic solvents. UV-A photoinduced electron transfer within the EDA complexes induces the mesolytic cleavage of the halide ion and radical recombination of the arenes leading, after rearomatization and proton loss to CÀ C or CÀ S coupling products. Depending on the substitution pattern selective and unique cross-couplings are observed. UV and NMR measurements reveal the importance of the assembly for the photoinduced reaction. Enforced EDA aggregate formation in water allows new activation modes for organic photochemical synthesis.

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