Solubilization in Lyotropic Liquid Crystals

Friberg, Stig E.; Wohn, Chang Sup; Uang, Yuh-Jye; Lockwood, Frances E.

doi:10.1080/01932698708943615

Cited by 10 publications

(1 citation statement)

References 16 publications

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“…Among liquid crystalline phases, lamellar phases have been used in the stabilization of emulsions or creams, 4 formation of liposomes, 5 sustained drug delivery, 6 make-up remover, 7 and the solubilization of low solubility drugs. 8,9 The cubic phase represents another form of a liquid crystalline phase. Recently, several studies have described its use as a sustained-release carrier for both conventional and peptide drugs.…”

Section: Introductionmentioning

confidence: 99%

Swelling of and Drug Release from Monoglyceride-Based Drug Delivery Systems

Chang

Bodmeier

1997

Journal of Pharmaceutical Sciences

110

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Depending on the water content, unsaturated monoglycerides form various liquid crystalline phases, which can be used as sustained-release carriers. The aim of this study was to investigate the water uptake of and drug release from melt-congealed monoglyceride-based drug carriers. The water uptake of the unsaturated monoglycerides monoolein and monolinolein followed second-order swelling kinetics and levelled off at about 50% water content, at which a highly viscous cubic phase was formed. The rapid formation of the cubic phase suggested that the drug release occurred mainly from this phase. The drug release followed the square-root of time relationship during the initial release phase. Chlorpheniramine maleate, an amphiphilic drug was not completely released because of binding to the cubic phase. The rate of water uptake increased and the maximum water uptake decreased with increasing temperature. The drug release could be controlled by varying the surface-to-volume ratio, the drug loading, and the water content of the lipid matrix. It was independent of the source of monoolein.

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Section: Introductionmentioning

confidence: 99%

Swelling of and Drug Release from Monoglyceride-Based Drug Delivery Systems

Chang

Bodmeier

1997

Journal of Pharmaceutical Sciences

110

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Influence of Protic Liquids on the Formation of Lyotropic Mesophases in Binary Systems with K‐Laurate

Dörfler

1994

Fett/Lipid

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Comparing the phase diagrams of three binary soap systems (soap:K-laurate = KClz) KCIZ/glycerol, KClz/ethylene glycol and KClz/butylene glycol we found alterations in the types of phase diagrams that depend on the protic solvents. A different polymorphism in the binary systems were observed which was dependent on the solvent. In the sys-crystalline phase, G = gel phase, H = hexagonal phase, L = lamellar phase, S = isotropic solution), in the binary system KClz/E: C cf G c* L c* S , in the binary system KCI2/B: C cf G cf L cf S . The differences in number, position, extension and sequence of occurring mesophases are a function of the composition in the binary systems and of the temperatures. We came to the conclusion that the influence, which the solution medium exerts on the formation of structures in the binary systems, is very distinct and pronounced * Author's address: Prof. Dr. habil. H.-D. Dorfler, Technische Universitat D r e s d e n , Lehrstuhl f u r Kolloidchemie, M o m m -senstraBe 13, D-01062 D r e s d e n , Germany. L i t e r a t u r e '

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Lyotropic Mesophases of K‐Palmitate in Protic Solvents

Dörfler

1994

Fett/Lipid

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Solubilization in Lyotropic Liquid Crystals

Cited by 10 publications

References 16 publications

Swelling of and Drug Release from Monoglyceride-Based Drug Delivery Systems

Swelling of and Drug Release from Monoglyceride-Based Drug Delivery Systems

Influence of Protic Liquids on the Formation of Lyotropic Mesophases in Binary Systems with K‐Laurate

Lyotropic Mesophases of K‐Palmitate in Protic Solvents

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