Solubilization of Hydrophilic Compounds in Copolymer Aggregates

Vauthey, Sylvain; Leser, Martin E.; Garti, Nissim; Watzke, Heribert J.

doi:10.1006/jcis.2000.6760

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…From a physico-chemical perspective it was thought to be interesting to compare these two compounds, due to their different aqeuous solubilities. Compared to several studies reported in the literature on ternary Pluronic systems [17,[28][29][30], the compounds studied here have such low aqeueous solubilities that they cannot be considered ''cosolvents". The article will discuss the results obtained for Pluronic P85 in detail.…”

Section: Introductionmentioning

confidence: 88%

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Solubilisation of model adjuvants by Pluronic block copolymers

Sharp

Washington

Cosgrove

2010

Journal of Colloid and Interface Science

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Section: Introductionmentioning

confidence: 88%

“…The focus of these studies has mainly been the solubilising capacity of the polymer and the partitioning of the organic compound between the polymer and the solvent [16][17][18]. Smallangle scattering techniques have, also been used to characterise these systems.…”

Section: Introductionmentioning

confidence: 99%

Solubilisation of model adjuvants by Pluronic block copolymers

Sharp

Washington

Cosgrove

2010

Journal of Colloid and Interface Science

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“…The location of the solubilizate and its extent of partitioning also depend on the nature of surfactant, size and shape of self-assembled structures and external factors such as the temperature, the presence of salt, and the solution pH. The solubilizing power and the partitioning of solubilizates between the surfactant and the solvent have been the subject of many publications [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Solubilization of Aromatic Hydrocarbons in Ethylene Oxide‐Propylene Oxide Triblock Micelles: Location of Solubilizate and its Effect on Micelle Size from 2D NMR and Scattering Techniques

Parekh

Singh²,

Marangoni³

et al. 2011

J Surfact & Detergents

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The solubilization of benzene and toluene in micellar solutions and the effects on the micellization and micelle size of ethylene oxide-propylene oxide triblock copolymers were investigated by dynamic light scattering (DLS), small angle neutron scattering (SANS), and 2D NMR spectroscopy. The copolymeric surfactants have the same size as the middle hydrophobic polypropylene oxide block (Mol. Wt. 3250) and varying polyethylene oxide end blocks (30, 40 and 50%). The solubilization and the properties of the micelles in the presence of the solubilizates were investigated; the results reveal that the more hydrophobic copolymer showed better solubilization. The cloud points of the copolymers decreased in the presence of oils; the depression in the cloud point is due to the formation of an electron donor-acceptor complex. DLS shows that the effect of benzene is dominated at high oil concentration. SANS data show that the micelles remain spherical in shape and that the micellar core size does not change with higher benzene concentration; observed changes in the low scattering vector region could be because of some small amount of benzene clusters formed at higher benzene concentration. Finally, the locus of solubilization of the oils in the copolymer micelles was determined via 2D NMR experiments. In all cases, significant nuclear Overhauser effect spectroscopy (NOESY) cross peaks were observed that appeared to correlate well with the expected loci of these solubilizates in micelles. Hence, the noninvasive NOESY technique provides important information on the location of the aromatic solubilizates in these copolymer micelles that depends on the structure of the oils.

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“…Furthermore, we were interested in particular in how the molar ratio of the EO/PO on the grafted copolymers influenced the release rate of δ-damascone. Besides being grafted onto polymeric profragrance bioconjugates to modify the polarity of the copolymers [20,23,27], EO and/or EO/PO copolymers of different types have also been of interest as physical delivery systems to modify fragrance evaporation, such as in the encapsulation into micellar systems [32][33][34][35][36]. The performance of the different polymer conjugates prepared in this work was investigated by dynamic headspace analysis on dry cotton under realistic conditions of functional perfumery in a fabric softening application [37] under the previously described conditions [27].…”

Section: Figurementioning

confidence: 99%

Controlled Release of Damascone from Poly(styrene-co-maleic anhydride)-based Bioconjugates in Functional Perfumery

Berthier¹,

Paret²,

Trachsel³

et al. 2013

Polymers

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Abstract:Poly(styrene-co-maleic anhydride)s were modified with poly(propylene oxide (PO)-co-ethylene oxide (EO)) side chains (Jeffamine ® ) with different EO/PO molar ratios, varying between 0.11 and 3.60. These copolymers were then further functionalized with a β-mercapto ketone of δ-damascone. The obtained poly(maleic acid monoamide)-based β-mercapto ketones were then studied as delivery systems for the controlled release of δ-damascone by retro 1,4-addition. The release of δ-damascone, a volatile, bioactive molecule of the family of rose ketones, was studied by dynamic headspace analysis above a cotton surface after deposition of a cationic surfactant containing fabric softening formulation, as a function of the ethylene oxide (EO)/propylene oxide (PO) molar ratio of the grafted copolymer side chains. The polarity of the EO/PO side chain influenced the release efficiency of the damascone in a typical fabric softening application. PO-rich copolymers and the corresponding poly(styrene-co-maleic anhydride) without Jeffamine ® side chains were found to be less efficient for the desired fragrance release than the corresponding bioconjugate with a EO/PO ratio of 3.60 in the side chain. This copolymer conjugate seemed to represent a suitable balance between hydrophilicity and hydrophobicity to favor the release of the δ-damascone and to improve the deposition of the conjugate from an aqueous environment onto a cotton surface.

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Solubilization of Hydrophilic Compounds in Copolymer Aggregates

Cited by 13 publications

References 28 publications

Solubilisation of model adjuvants by Pluronic block copolymers

Solubilisation of model adjuvants by Pluronic block copolymers

Solubilization of Aromatic Hydrocarbons in Ethylene Oxide‐Propylene Oxide Triblock Micelles: Location of Solubilizate and its Effect on Micelle Size from 2D NMR and Scattering Techniques

Controlled Release of Damascone from Poly(styrene-co-maleic anhydride)-based Bioconjugates in Functional Perfumery

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