Soluble arabinoxylan alters digesta flow and protein digestion of red meat-containing diets in pigs

Zhang, Dagong; Williams, Barbara A.; Mikkelsen, Deirdre; Li, Xiuhua; Keates, H.; Lisle, Allan; Collins, Helen; Bird, Anthony R.; Topping, David L.; Gidley, Michael J.; Bryden, W. L.

doi:10.1016/j.nut.2015.03.006

Cited by 27 publications

(16 citation statements)

References 36 publications

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“…Bacteria belonging to these clusters are known to produce a range of metabolites from protein breakdown, including ammonia, indole and sulphides (Hughes, Magee & Bingham, 2000). Here, the decrease in C. hystoliticum Clusters I & II was positively correlated with the decreased levels of ammonia observed for the AX caecal digesta samples as reported by Zhang et al, (2015).…”

Section: Accepted Manuscriptsupporting

confidence: 78%

“…All animal procedures were approved by the Animal Ethics Committees of the University of Queensland (AEC Approval Number SAS/181/09/CSIRO-NF). Zhang et al (2015) describes in detail the experimental design, diets, and digesta sampling procedures. In brief, the four diets composed of red meat (either 23.6% or 30%), with or without an enriched wheat fraction (AXRF) that contained soluble AX, starch (adjusted according to the starch content of the AXRF), wheat bran (containing insoluble AX), oils, fats, salt, vitamins & minerals.…”

Section: Digesta Sampling and Preservationmentioning

confidence: 99%

“…In effect, the null hypothesis asserts that the medians of the two samples are identical (Lehmann 2006). SCFA, ammonia and pH data from the study by Zhang et al, (2015) Gori et al, (2011) using a special oligosaccharide prebiotic mixture rather than AX in the diet. Bacteria belonging to these clusters are known to produce a range of metabolites from protein breakdown, including ammonia, indole and sulphides (Hughes, Magee & Bingham, 2000).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Major SCFA, Total SCFA and NH 3 concentrations in the caecal digesta;Means with SE's (in brackets) (fromZhang et al, 2015) …”

mentioning

confidence: 99%

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Visualization of microbe-dietary remnant interactions in digesta from pigs, by fluorescence in situ hybridization and staining methods; effects of a dietary arabinoxylan-rich wheat fraction

et al. 2016

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Section: Accepted Manuscriptsupporting

confidence: 78%

Section: Digesta Sampling and Preservationmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Major SCFA, Total SCFA and NH 3 concentrations in the caecal digesta;Means with SE's (in brackets) (fromZhang et al, 2015) …”

mentioning

confidence: 99%

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Visualization of microbe-dietary remnant interactions in digesta from pigs, by fluorescence in situ hybridization and staining methods; effects of a dietary arabinoxylan-rich wheat fraction

et al. 2016

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“…All the analyses were performed by Metabolomics Australia (Melbourne, VIC, Australia). AIA content was also analyzed on these samples using the method described by Zhang et al (13).…”

Section: Digesta and Fecesmentioning

confidence: 99%

Reduction in circulating bile acid and restricted diffusion across the intestinal epithelium are associated with a decrease in blood cholesterol in the presence of oat β‐glucan

et al. 2016

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Although oat (1,3:1,4)-β-glucan (BG) has been shown to decrease blood cholesterol in intervention trials, the detailed mechanism is not yet defined, but restricted reabsorption of bile acids (BAs) has been hypothesized. Using pigs as a model for humans we demonstrated that, compared to the control, BG added to the diet for 26 d caused decreases of 24% in blood total BAs (TBAs), 34% in total cholesterol (TC), and 57% in LDL cholesterol (LDL-C) (P < 0.01); decreases of 20% TBA in the midjejunum and terminal ileum (P < 0.01); increases of 80% in cecal total neutral sterols (TNSs) including cholesterol (P < 0.01); a 50% reduction in BA active transport across ex vivo ileum after 40 min (P < 0.001); and 32% decrease in jejunal microvillus heights with apparent increased goblet cell activity. The results suggest that BG not only physically hinders the active reabsorption of BAs and uptake of cholesterol, but also changes the BAs profile with lower circulating levels without excess excretion in the feces, thus resulting in reduced blood TC and LDL-C. Fermentation of sterols reaching the colon enhanced production of therapeutic ursodeoxycholic acid, suppressed toxic lithocholic acid, and decreased the possibility of cholesterol absorption by transforming the latter into coprostanol, a nonabsorbable NS.-Gunness, P., Michiels, J., Vanhaecke, L., De Smet, S., Kravchuk, O., Van de Meene, A., Gidley, M. J. Reduction in circulating bile acid and restricted diffusion across the intestinal epithelium are associated with a decrease in blood cholesterol in the presence of oat β-glucan.

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Circulating triglycerides and bile acids are reduced by a soluble wheat arabinoxylan via modulation of bile concentration and lipid digestion rates in a pig model

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et al. 2016

Molecular Nutrition Food Res

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Soluble arabinoxylan alters digesta flow and protein digestion of red meat-containing diets in pigs

Cited by 27 publications

References 36 publications

Visualization of microbe-dietary remnant interactions in digesta from pigs, by fluorescence in situ hybridization and staining methods; effects of a dietary arabinoxylan-rich wheat fraction

Visualization of microbe-dietary remnant interactions in digesta from pigs, by fluorescence in situ hybridization and staining methods; effects of a dietary arabinoxylan-rich wheat fraction

Reduction in circulating bile acid and restricted diffusion across the intestinal epithelium are associated with a decrease in blood cholesterol in the presence of oat β‐glucan

Circulating triglycerides and bile acids are reduced by a soluble wheat arabinoxylan via modulation of bile concentration and lipid digestion rates in a pig model

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