Soluble CD163: a biomarker linking macrophages and insulin resistance

Parkner, Tina; Sørensen, Lars Peter; Nielsen, Annemette; Fischer, Christian P.; Bibby, Bo Martin; Nielsén, Sören; Pedersen, Bente Klarlund; Møller, Holger Jon

doi:10.1007/s00125-012-2533-1

Cited by 93 publications

(90 citation statements)

References 30 publications

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“…We did not find any association to glucose variables, presumably because increased fasting and post-load glucose are relatively late events in the pathogenesis of dysglycaemic progression, and because participants with diabetes diagnosed during follow-up were excluded by our study design. Our finding of time-independent associations between sCD163 and insulin resistance and insulin secretion strengthens the evidence from previous cross-sectional studies [7,20]. Our study is in agreement with other studies that found adiponectin to be negatively associated with changes in post-load glucose, insulin resistance and insulin secretion [21][22][23].…”

Section: Discussionsupporting

confidence: 93%

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Soluble CD163, adiponectin, C-reactive protein and progression of dysglycaemia in individuals at high risk of type 2 diabetes mellitus: the ADDITION-PRO cohort

et al. 2016

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Aim/hypothesis Our aim was to investigate the association between the macrophage-activation marker soluble CD163 (sCD163), adiponectin, C-reactive protein (CRP) and changes in glycaemia, insulin resistance and insulin secretion in individuals at high risk of type 2 diabetes mellitus. Conclusions/interpretation Our findings indicate that mechanisms related to inflammation, including macrophage activation and adipocyte metabolism, may play a role in changes in glucose homeostasis in individuals at high risk of type 2 diabetes mellitus.

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Section: Discussionsupporting

confidence: 93%

“…High circulating levels of sCD163 are associated with obesity, insulin resistance and type 2 diabetes mellitus in cross-sectional studies [7][8][9]. sCD163 is furthermore associated with incident type 2 diabetes mellitus in a prospective study [10].…”

Section: Introductionmentioning

confidence: 97%

Soluble CD163, adiponectin, C-reactive protein and progression of dysglycaemia in individuals at high risk of type 2 diabetes mellitus: the ADDITION-PRO cohort

et al. 2016

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“…Furthermore, there is a significant association between the insulin resistance measured by HOMA-IR and the level of sCD163 and the expression of CD163 in obese subjects (Zanni et al 2011, Fjeldborg et al 2013, Kračmerováet al 2014. Finally, sCD163 is found to be strongly associated with the development of type 2 diabetes (Parkner et al 2012).…”

Section: Introductionmentioning

confidence: 94%

Regulation of CD163 mRNA and soluble CD163 protein in human adipose tissue in vitro

Fjeldborg

Møller

Richelsen

et al. 2014

Journal of Molecular Endocrinology

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CD163-positive macrophages are highly expressed in the human adipose tissue (AT) particularly from obese individuals. However, little is known about the regulation of CD163 mRNA and the protein level of sCD163 in human AT. We aimed to examine the regulation of CD163 and sCD163 in AT. Human s.c. AT samples (nZ5) were stimulated with dexamethasone (DEX; 200 nmol/l), lipopolysaccharide (LPS; 100 ng/ml), or DEXCLPS for various time periods up to 24 h. Gene expressions of CD163, ADAM17, IL10, and TNFA (TNF) were measured by RT-PCR. Protein levels of sCD163, IL10, and TNFa (TNF) were measured by ELISA. Furthermore, AT was separated into stromal and adipocyte fraction. We found that CD163 mRNA was strongly expressed in the stromal vascular fraction but hardly detectable in the isolated adipocytes. Incubating whole AT with DEX significantly up-regulated CD163 (P!0.001), whereas incubation with LPS had no effects on CD163 (PO0.05). By contrast, the protein level of sCD163 was not affected by DEX (PO0.05), but LPS significantly increased the level of sCD163 and TNFa (P!0.05). This might be due to the concomitant LPS stimulation of ADAM17, which is known to mediate shedding of the extracellular domains of sCD163 and TNFa. Finally, DEX significantly reduced the LPS-induced TNFa release to the incubation medium but had no effects on sCD163. We conclude that the expression of CD163 and the release of sCD163 are differentially regulated in human AT. Moreover, similar to studies on differentiated blood monocytes, TNFa and sCD163 are concomitantly released in human AT by LPS, which also up-regulate ADAM17.

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“…pioglitazone) to improve insulin sensitivity and decrease risk of CVD events [58,59]. Due to the fact that many of these drugs have been shown to affect adipose tissue differentiation, inflammation, and consequently insulin sensitivity [60][61][62], studies have began to focus on adipose tissue as another important organ contributing to CVD risk in obese populations [63,64].…”

Section: Mechanisms Of Insulin Resistance Hyperglycemia and Dyslipimentioning

confidence: 99%

Dyslipidemia: Relationship to Insulin Resistance, Fatty Liver, and Sub-Clinical Atherosclerosis

2015

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In the United States (U.S.) there is a high prevalence of overweight and obesity, affecting nearly 32 % of youth and 69 % of adults [1]. Compared to the national average, these prevalence estimates are even higher among minority groups where approximately 70 % of African American (AA) and Hispanic adults, but only 57 % of Caucasian adults are considered overweight and obese [1]. Across all segments of the population, obesity-associated diseases such as type 2 diabetes (T2D), cardiovascular disease (CVD), and non-alcoholic fatty liver disease (NAFLD) have contributed to $ 48-$ 66 billion a year in projected medical costs [2]. Perhaps more alarming is the fact that obesity rates are expected to increase to 51 % by 2030 [3]. Concurrent to national increases in obesity, minority children and adults are experiencing disproportionate risk for obesity-related diseases, where AAs and Hispanics are more affected by T2D and CVD than Caucasians and Asians [2,4]. Of particular concern is the observation that overweight and obese children tend to become obese adults [5], highlighting the importance of understanding disease pathophysiology in order to prevent disease. In this regard, studies have identified specific patterns of fat distribution and ectopic fat as being linked with increased

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Soluble CD163: a biomarker linking macrophages and insulin resistance

Cited by 93 publications

References 30 publications

Soluble CD163, adiponectin, C-reactive protein and progression of dysglycaemia in individuals at high risk of type 2 diabetes mellitus: the ADDITION-PRO cohort

Soluble CD163, adiponectin, C-reactive protein and progression of dysglycaemia in individuals at high risk of type 2 diabetes mellitus: the ADDITION-PRO cohort

Regulation of CD163 mRNA and soluble CD163 protein in human adipose tissue in vitro

Dyslipidemia: Relationship to Insulin Resistance, Fatty Liver, and Sub-Clinical Atherosclerosis

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