Soluble E-cadherin in Systemic Lupus Erythematosus

Jin, Tao; Almehed, Katarina; Zhu, Yingjun; Carlsten, Hans; Forsblad-d’Elia, Helena

doi:10.3899/jrheum.130518

Cited by 7 publications

(3 citation statements)

References 40 publications

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“…Of them, 17 were excluded due to duplicates, irrelevance, or inappropriateness. Of the remaining 14 studies, 3 were excluded (2 lacked numerical figures, and 1 did not report MMP-3 levels in controls) to finally include 11 eligible articles (Figure 1) [2, 3, 12, 15–22]. Here, we included results from a national pediatric SLE cohort (KPS) involving 11 SLE and 9 healthy controls.…”

Section: Resultsmentioning

confidence: 99%

Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis

et al. 2019

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Introduction. Matrix metalloproteinase (MMP) is an emerging disease marker in rheumatic diseases. This is a meta-analysis aimed at systematically reviewing association between serum MMP-3 levels and systematic lupus erythematosus (SLE) activity, which sought to raise interest in MMP-3 as a putative biomarker. Methods. We conducted a meta-analysis of serum MMP-3 levels in patients with SLE and controls. We performed a PubMed search, EMBASE search, and forward search of the retrieved articles published until Oct. 1, 2018. In addition to this, we included data from a case-control study on a national pediatric SLE cohort, in which serum MMP-3 levels were measured in 11 SLE patients and 9 controls (unpublished). Subgroup analyses based on gender and disease activity were performed. Results. A total of 662 cases and 771 controls including 651 patients and 762 controls from 11 publications were studied. We observed significantly higher MMP-3 levels in SLE patients compared to healthy controls (P<0.001, Hedges’ g: 2.104, 95% CI 1.426-2.782). In subgroup analyses, we found a significant elevation of MMP-3 in the patients with nephritis compared to those without (P=0.006, Hedges’ g: 0.611, 95% CI 0.611-1.704). This finding was consistent between patients with persistent proteinuria and those without (P=0.023, Hedges’ g: 1.535, 95% CI 0.207-2.862). Meta-analysis showed no association between MMP-3 levels and gender or anti-double strand DNA antibody titer. Conclusions. Our meta-analysis demonstrated significantly higher MMP-3 levels in SLE patients than in controls and in patients with renal involvement than in those without.

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Section: Resultsmentioning

confidence: 99%

Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis

et al. 2019

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“…Here, we detected soluble E‐cadherin (sE‐cadherin) as mechanical cytokines in the exudate as well. Soluble E‐cadherin was an end product of proteolytic cleavage of E‐cadherin (Jin, Almehed, Zhu, Carlsten, & Forsblad‐d'Elia, ). It has been associated with the presence of tissue injury and inflammation (Karayiannakis et al, ).…”

Section: Discussionmentioning

confidence: 99%

Transferring the exudate in the tissue engineering chamber as a trigger to incubate large amount adipose tissue in remote area

Chen

Dong

Wan

et al. 2017

J Tissue Eng Regen Med

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Tissue engineering chamber (TEC) is a technique that could incubate up to 16 folds volume increase of a fat flap. But the mechanism in the silicone chamber was still unknown. The function of exudate in the chamber was noticed recently. We developed a special model called fluid drainage model (FDM) that consisted of a traditional TEC on the back and paired fat flaps without a chamber in the groins. Then we used a silicon tube to dynamically transfer the exudate from dorsal TEC to one of the paired inguinal fat flap and the other inguinal fat flap with a sham tube was set as control. At Week 4, the volume of drainage group reached 8.7 ± 2.3 ml, 576 ± 152% to its original volume whereas the growth ratio of control group was only 130 ± 39%. Similar volume change and histological change were observed within fat flap from TEC model and drainage group. The exudate in the TEC is a heterogeneous cocktail contains cytokines as well as cells. Intriguingly, transferred exudate in the TEC model sustain the ability to incubate large amount of adipose tissue remotely.

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“…Recently, growing evidence suggests that the serum increased sE‐cadherin levels may be connected with the severity of systemic inflammatory response as well as multiorgan failure . For example, it has been reported that (a) the serum concentrations of sE‐cadherin in seven severe acute pancreatitis patients are significantly higher than those in 19 mild acute pancreatitis patients, and (b) the serum concentrations of sE‐cadherin, which are in direct proportion to markers of inflammation and organ damage, such as disease duration, interleukin 6 (IL‐6) and erythrocyte sedimentation rate, are obviously augmented in patients with systemic lupus erythematosus compared with those in healthy controls . Interestingly, our results also show that serum sE‐cadherin may be a key biomarker of the pathogenesis of HBV‐associated disorders progression .…”

Section: Discussionmentioning

confidence: 99%

Soluble E‐cadherin is associated with oxidative stress in patients with chronic HBV infection

Yang

Xiong

Zhou

et al. 2019

Journal of Medical Virology

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Mounting evidence indicates that serum soluble E-cadherin (sE-cadherin) serves as an important player in various physiological and pathological processes. However, the crosstalk between serum sE-cadherin and oxidative stress in chronic hepatitis B (CHB) remains to be illustrated. The main purpose of this study is to explore the molecular mechanisms underlying the function of sEcadherin in CHB virus infection. Levels of serum sE-cadherin, total antioxidant capacity (TAC), glutathione (GSH), superoxide dismutase (SOD), total oxidant activity (TOA), NADPH oxidase 2 (NOX2), and malondialdehyde (MDA), from 51 patients with hepatitis B envelope antigen (HBeAg)-negative CHB, 54 patients with HBeAg-positive CHB, and 109 healthy individuals were detected by enzyme-linked immunosorbent assay. In our study, patients with CHB showed significantly higher serum sE-cadherin levels than healthy individuals (P < .01). Furthermore, we also found that the serum sE-cadherin levels were significantly negatively correlated with TAC, antioxidant enzymes (GSH and SOD) in patients with CHB, and that serum sE-cadherin concentrations were significantly positively correlated with liver enzyme markers (alanine transaminase and aspartate aminotransferase) and oxidative markers (TOA, NOX2, and MDA) in patients with CHB. Therefore, serum sE-cadherin may act as a new candidate biomarker for reflecting inflammation and oxidative stress status in the development and progression of hepatitis B virus infection. K E Y W O R D S chronic hepatitis B, hepatitis B virus, NOX2, oxidative stress, sE-cadherin

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Soluble E-cadherin in Systemic Lupus Erythematosus

Cited by 7 publications

References 40 publications

Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis

Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis

Transferring the exudate in the tissue engineering chamber as a trigger to incubate large amount adipose tissue in remote area

Soluble E‐cadherin is associated with oxidative stress in patients with chronic HBV infection

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