Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial

Jenkins, David; Kendall, Cyril W.C.; Vuksan, Vladimir; Vidgen, Edward; Parker, Tina; Faulkner, Dorothea; Mehling, Christine C.; Garsetti, Marcella; Testolin, G.; Cunnane, Stephen C.; Ryan, Mary Ann; Corey, Paul

doi:10.1093/ajcn/75.5.834

Cited by 220 publications

(141 citation statements)

References 24 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…The finding that some LKFibre products were rated less acceptable than their respective controls suggests that reformulation at a lower LKFibre incorporation rate may be necessary to obtain optimal product acceptance. From the present study and earlier sensory work (Clark & Johnson, 2002), it appears that LKFibre is suitable for incorporation into a range of food matrices and that it may have advantages, in terms of product acceptability, over soluble viscous lipid-lowering dietary fibres (Jenkins et al, 2002b).…”

Section: Discussionsupporting

confidence: 60%

“…Based on the 2% reduction in CHD risk for each 1% reduction in LDL-C concentration suggested by LRC-CPPT (1984), E9% reduction in CHD risk can be predicted based on the mean treatment effect of a 4.5% reduction in TC found in the present study. These effects are similar to those of soluble viscous dietary fibres such as psyllium, guar gum and b-glucans (Brown et al, 1999;Anderson et al, 2000b;Jenkins et al, 2002b;Kerckhoffs et al, 2003). Nevertheless, studies comparing the effects of LKFibre with those of established cholesterol-lowering fibres, in equi-fibre diets, are now required.…”

Section: Discussionmentioning

confidence: 83%

“…In general, soluble dietary fibres such as psyllium, pectin and the legume-derived guar gum are considered to be hypocholesterolaemic agents (Brown et al, 1999;Anderson et al, 2000a, b;Jenkins et al, 2002b). Nevertheless, the ability of these soluble fibres to impact positively on consumer health has been questioned due to difficulties in incorporating them into palatable food products (Jenkins et al, 2002b).…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the ability of these soluble fibres to impact positively on consumer health has been questioned due to difficulties in incorporating them into palatable food products (Jenkins et al, 2002b). Insoluble dietary fibres such as wheat bran and cellulose are widely used as commercial ingredients for fibre enrichment of food products such as baked goods and breakfast cereals, but have not demonstrated beneficial lipid-modifying effects (Anderson & Chen, 1979).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lupin kernel fibre-enriched foods beneficially modify serum lipids in men

et al. 2004

View full text Add to dashboard Cite

Objective: To examine the effect of a diet containing a novel legume food ingredient, Australian sweet lupin (Lupinus angustifolius) kernel fibre (LKFibre), compared to a control diet without the addition of LKFibre, on serum lipids in men. Design: Randomized crossover dietary intervention study. Setting: Melbourne, Australia -Free-living men. Subjects: A total of 38 healthy males between the ages of 24 and 64 y completed the intervention. Intervention: Subjects consumed an LKFibre and a control diet for 1 month each. Both diets had the same background menus with seven additional experimental foods that either contained LKFibre or did not. Depending on energy intake, the LKFibre diet was designed to contain an additional 17 to 30 g/day fibre beyond that of the control diet. Results: Compared to the control diet, the LKFibre diet reduced total cholesterol (TC) (mean7s.e.m.; 4.571.7%; P ¼ 0.001), low-density lipoprotein cholesterol (LDL-C) (5.472.2%; P ¼ 0.001), TC: high-density lipoprotein cholesterol (HDL-C) (3.072.0%; P ¼ 0.006) and LDL-C:HDL-C (3.872.6%; P ¼ 0.003). No effects on HDL-C, triacylglycerols, glucose or insulin were observed. Conclusions: Addition of LKFibre to the diet provided favourable changes to some serum lipid measures in men, which, combined with its high palatability, suggest this novel ingredient may be useful in the dietary reduction of coronary heart disease risk.

show abstract

Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lupin kernel fibre-enriched foods beneficially modify serum lipids in men

et al. 2004

View full text Add to dashboard Cite

show abstract

“…In general, soluble fibre does not seem to have potential triglyceride lowering properties [10 13]. However, some animal studies [6] and human studies [15] suggest otherwise. Jenkins et al [15] conducted a randomised, controlled two-way crossover study to investigate the effect of a high fibre diet on the lipid profile of hyperlipidaemic subjects, demonstrating a significant total cholesterol and triglyceride-lowering effect of the high-fibre diet compared to the control diet.…”

Section: Introductionmentioning

confidence: 99%

Alginate reduces the increased uptake of cholesterol and glucose in overweight male subjects: a pilot study

et al. 2008

View full text Add to dashboard Cite

We have used a cross-over study design in human subjects to monitor the uptake of glucose, cholesterol and triacylglycerides (TAG) in human subjects with normal and high body mass index (BMI). Our pilot data demonstrate that uptakes of glucose, TAG and cholesterol are all increased with increasing percentage body fat, and that a 1.5g dose of a strong-gelling alginate may restore uptake of cholesterol and glucose to normal levels.

show abstract

Dietary Fiber and Risk of Coronary Heart Disease

et al. 2004

View full text Add to dashboard Cite

Background: Few epidemiologic studies of dietary fiber intake and risk of coronary heart disease have compared fiber types (cereal, fruit, and vegetable) or included sex-specific results. The purpose of this study was to conduct a pooled analysis of dietary fiber and its subtypes and risk of coronary heart disease. Methods:We analyzed the original data from 10 prospective cohort studies from the United States and Europe to estimate the association between dietary fiber intake and the risk of coronary heart disease.Results: Over 6 to 10 years of follow-up, 5249 incident total coronary cases and 2011 coronary deaths occurred among 91058 men and 245186 women. After adjustment for demographics, body mass index, and lifestyle factors, each 10-g/d increment of energy-adjusted and measure-ment error-corrected total dietary fiber was associated with a 14% (relative risk [RR], 0.86; 95% confidence interval [CI], 0.78-0.96) decrease in risk of all coronary events and a 27% (RR, 0.73; 95% CI, 0.61-0.87) decrease in risk of coronary death. For cereal, fruit, and vegetable fiber intake (not error corrected), RRs corresponding to 10-g/d increments were 0.90 (95% CI, 0.77-1.07), 0.84 (95% CI, 0.70-0.99), and 1.00 (95% CI, 0.88-1.13), respectively, for all coronary events and 0.75 (95% CI, 0.63-0.91), 0.70 (95% CI, 0.55-0.89), and 1.00 (95% CI, 0.82-1.23), respectively, for deaths. Results were similar for men and women.Conclusion: Consumption of dietary fiber from cereals and fruits is inversely associated with risk of coronary heart disease.

show abstract

Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial

Cited by 220 publications

References 24 publications

Lupin kernel fibre-enriched foods beneficially modify serum lipids in men

Lupin kernel fibre-enriched foods beneficially modify serum lipids in men

Alginate reduces the increased uptake of cholesterol and glucose in overweight male subjects: a pilot study

Dietary Fiber and Risk of Coronary Heart Disease

Contact Info

Product

Resources

About