Soluble fibrin monomer complex is associated with cardio- and cerebrovascular events in patients with heart failure

Yoshihisa, Akiomi; Sato, Yu; Kimishima, Yusuke; Ichijo, Yasuhiro; Yokokawa, Tetsuro; Misaka, Tomofumi; Sato, Toshio; Oikawa, Masayoshi; Kobayashi, Atsushi; Nakazato, Kazuhiko; Takeishi, Yasuchika

doi:10.1016/j.ijcha.2020.100697

Cited by 7 publications

(9 citation statements)

References 48 publications

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“…27,28, 30 Major adverse cardiac and cerebrovascular events were defined as non-fatal and fatal cardio-and cerebrovascular events, such as myocardial infarction and stroke. 31 The definition of cardiac death was in accordance with our previous studies. 32, 33 The patient characteristics consisted of demographic data obtained at hospital discharge, past medical history, medication, laboratory data, and echocardiographic data.…”

Section: Discussionmentioning

confidence: 98%

Simplified Academic Research Consortium for High Bleeding Risk (ARC-HBR) Definition Predicts Bleeding Events in Patients With Heart Failure

Sato

Yoshihisa

Takeishi

et al. 2021

Circ J

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Background: It has recently been reported that the simplified Academic Research Consortium for High Bleeding Risk (ARC-HBR) definition, which excludes 6 rare criteria, is comparable to the original ARC-HBR definition in predicting major bleeding in patients with coronary artery disease (CAD) who undergo percutaneous coronary intervention. In this study, we investigated whether the simplified ARC-HBR definition could be applied to patients with heart failure (HF) to identify those at high bleeding risk (HBR). Methods and Results:In all, 2,437 patients hospitalized for HF were enrolled in this study. Patients were divided into 2 groups based on the simplified ARC-HBR definition: those at HBR (n=2,026; 83.1%) and those not (non-HBR group; n=411; 16.9%). The HBR group was older (72.0 vs. 61.0 years; P<0.001) and had a lower prevalence of CAD (31.1% vs. 36.5%; P=0.034) than the non-HBR group. Kaplan-Meier analysis showed that post-discharge bleeding events defined as hemorrhagic stroke or gastrointestinal bleeding were more frequent in the HBR than non-HBR group (log-rank P<0.001). The simplified ARC-HBR definition accurately predicted bleeding events (Fine-Gray model; hazard ratio 2.777, 95% confidence interval 1.464-5.270, P=0.001). Conclusions:The simplified ARC-HBR definition predicts a high risk of bleeding events in patients with HF.

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Section: Discussionmentioning

confidence: 98%

Simplified Academic Research Consortium for High Bleeding Risk (ARC-HBR) Definition Predicts Bleeding Events in Patients With Heart Failure

Sato

Yoshihisa

Takeishi

et al. 2021

Circ J

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“…Returning to the hypothesis posed at the beginning of this study, it is now possible to state that test for SFMC plasma level has clinical A c c e p t e d a r t i c l e significance in patients with CAD, and elevated level of these molecular complexes could be implicated as a risk factor for cardiovascular events. Furthermore, an increased SFMC level is typical for the development of ischemic stroke, disseminated intravascular coagulation, autoimmune diseases and thrombophilia [14,21,26].…”

Section: Discussionmentioning

confidence: 99%

“…However, the pathophysiological mechanisms by which fibrinogen is involved in thrombogenesis still remains to be determined. A recent study by Akiomi Yoshihisa, et.al [14] has revealed that the high level of soluble fibrin monomer complexes (SFMCs), produced by thrombin-mediated cleavage of fibrinogen in a hypercoagulable state, was associated with the risk of adverse cardiovascular events and could be considered as a very sensitive biomarker for prediction of thrombotic events in heart failure patients. On the other hand, in other study [15] it was shown that SFMC levels did not predict subsequent thromboembolic events.…”

Section: A C C E P T E D a R T I C L Ementioning

confidence: 99%

Coagulation markers in patients with coronary artery disease

et al. 2022

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Coronary artery disease (CAD) is a major public health problem all over the world, and although diagnostic and treatment approaches are improving, the majority of individuals who suffer CAD will not survive. Therefore, it is a clinical demand to find out new biomarkers for identification of CAD in the earlier stage. The purpose of this study was to determine whether qualitative and quantitative alterations of plasma soluble fibrin monomer complexes (SFMCs) are associated with cardiovascular events. Additionally, some other well-known biomarkers of hypercoagulation state, such as fibrinogen, and prothrombin were analyzed in plasma of patients with different coronary artery pathologies. We found that plasma SFMC concentrations were remarkably increased in all tested CAD groups. Moreover, the development of CAD was accompanied by the changes in both quantity and quality of SFMC composition compared to that of healthy subjects. Our results also demonstrated the elevated level of high molecular weight vitamin K-dependent protein (VKDP) complexes in plasma of CAD patients which could be used as a potential biomarker of hypercoagulation state. More studies are clearly needed to investigate whether SFMCs or abnormal forms of VKDPs affect cardiovascular events under CAD development and progression.

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“…An additional marker for MACCE and all-cause mortality to be potentially considered in evolving concepts of risk assessment is the soluble fibrin monomer complex (SFMC), as proposed in this journal by Yoshihisa et al [22] . As comprehensively detailed in the study and discussed in the accompanying editorial [22] , [23] , SFMC could be implemented as an early sentinel for a pre-coagulant state and predictive biomarker in patients with heart failure. An innovative method for SFMC quantification was presented, coupling immunoturbidity with coagulometry to allow measurement of serum proteins not detectable with conventional clinical chemistry methods.…”

Section: Evolving Concepts For Risk Prediction and Scoringmentioning

confidence: 99%

Recent highlights on thrombosis and hemostasis from the International Journal of Cardiology: Heart & Vasculature

Fender¹,

Dobrev²

2022

IJC Heart & Vasculature

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Soluble fibrin monomer complex is associated with cardio- and cerebrovascular events in patients with heart failure

Abstract: Highlights The soluble fibrin monomer complex (SFMC), is a marker of fibrin formation. SFMC is abnormally elevated in a variety of clinical situations of hypercoagulability. SFMC is an independent predictor of adverse prognosis in patients with heart failure.

Cited by 7 publications

References 48 publications

Simplified Academic Research Consortium for High Bleeding Risk (ARC-HBR) Definition Predicts Bleeding Events in Patients With Heart Failure

Simplified Academic Research Consortium for High Bleeding Risk (ARC-HBR) Definition Predicts Bleeding Events in Patients With Heart Failure

Coagulation markers in patients with coronary artery disease

Recent highlights on thrombosis and hemostasis from the International Journal of Cardiology: Heart & Vasculature

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