Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions

Abstract

Introduction: An imbalance in type 1 (Th1) and type 2 (Th2) T helper cells is associated with the development and recurrence of condyloma acuminatum (CA); however, the mechanisms underlying this imbalance remain unknown. We investigated soluble fibrinogen-like protein 2 (sFGL2), which is an effector of regulatory T cells (Tregs), to determine its role in the Th1/Th2 imbalance of CA.
 Methodology: Lesion and blood samples were obtained from 30 CA patients, and these samples were compared with genital skin and blood samples from 20 control subjects. Serum sFGL2, mRNA, and protein levels were estimated using ELISA, quantitative real-time polymerase chain reaction, and western blot, respectively. Immunohistochemical analyses were also conducted.
 Results: Compared to controls, CA patients had decreased serum sFGL2 levels. However, sFGL2 mRNA and protein levels in the lesions of CA patients were significantly increased. Interleukin (IL)-4 and Foxp3 mRNA levels were upregulated, and interferon (IFN)-γ levels were downregulated in CA patients compared to those in controls. Additionally, the sFGL2 mRNA level positively correlated with Foxp3 and IL-4 levels and negatively correlated with IFN-γ and IL-17 levels.
 Conclusion: sFGL2 contributes to the underlying Th1/Th2 imbalance in CA pathogenesis.

Clinical Efficacy of Carbon Dioxide Laser Combined with ALA Photodynamics in the Treatment of Condyloma Acuminatum

“…CA is caused by human papillomavirus infection [ 7 , 8 ]. It often occurs in the anus and external genitalia.…”

Identification of key biomarkers and immune infiltration in the thoracic acute aortic dissection by bioinformatics analysis

“…Previous studies found that FGL2 has immunosuppressive effects on adaptive immunity by inhibiting dendritic cell maturation, downregulating T cell function and inducing B cell apoptosis [ 27 ], and the present study found that it is associated with infiltration of neutrophils and NK cells in AD. FGL2 is mainly derived from regulatory T cells (Tregs), and it reduces the production of IFN-γ and IL-17 [ 13 , 28 ]. Whereas regulatory T cells have low expression in AD [ 19 , 29 ], IFN-γ and IL-17 are highly expressed in AD [ 19 , 30 ].…”

“…C Correlation between FGL2 and infiltrating immune cells. AD, aortic dissection cells (Tregs), and it reduces the production of IFN-γ and IL-17 [13,28]. Whereas regulatory T cells have low expression in AD [19,29], IFN-γ and IL-17 are highly expressed in AD [19,30].…”

Механизмы Межклеточных Взаимодействий В Слизистой Оболочке Репродуктивного Тракта Женщин В Возрастном Аспекте

“…Кондиломы возникают в результате папилломавирусной инфекции (HPVI), выявляются на фоне эктопии в 1,9% случаев преимущественно в группе женщин до 35 лет. Различают экзофитные остроконечные кондиломы и эндофитные формы кондилом (плоские кондиломы) [174]. В плане малигнизации наибольшее значение имеют плоские кондиломы.…”