Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases ζ/β as the putative F3 receptors on Schwann cells

Thomaidou, Dimitra; Coquillat, Delphine; Meintanis, Stathis; Noda, Masaharu; Rougon, Geneviève; Matsas, Rebecca

doi:10.1046/j.1471-4159.2001.00454.x

Cited by 49 publications

(29 citation statements)

References 57 publications

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“…Interestingly, GFAP expression is also associated with migrating, dedifferentiated glial cells [Cheng and Zochodne, 2002], and both GFAP and NCAM expression have been positively correlated with the migratory capacity of Schwann cells [Cheng and Zochodne, 2002;Massaro, 2002;Thomaidou et al, 2001]. Thus, a potential implication of our work is that BMPs may facilitate the migratory potential of Schwann cells during development.…”

Section: Discussionmentioning

confidence: 67%

Inhibition of Glial Maturation byBone Morphogenetic Protein 2 in a Neural Crest-Derived Cell Line

Dore¹,

Crotty²,

Birren³

2005

Dev Neurosci

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Bone morphogenetic proteins (BMPs) regulate developmental decisions in many neural and nonneural lineages. BMPs influence both CNS neuronal and glial development and promote neuronal differentiation in neural crest derivatives. We investigated the actions of BMP2 on glial differentiation in the peripheral nervous system using NCM1 cells, a neural crest-derived cell line with the properties of peripheral glial precursor cells. BMP2 prevented the acquisition of a mature Schwann cell-like morphology, blocking the expression of mature genes and maintaining expression of several early glial markers. We provide evidence that BMP2 activates the GFAP promoter and define signaling pathways underlying this regulation. Our results demonstrate a novel role for BMPs as inhibitors of glial differentiation in the peripheral nervous system and suggest that BMPs may regulate the developmental timing of glial maturation.

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Section: Discussionmentioning

confidence: 67%

Inhibition of Glial Maturation byBone Morphogenetic Protein 2 in a Neural Crest-Derived Cell Line

Dore¹,

Crotty²,

Birren³

2005

Dev Neurosci

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“…However, their integration into the host environment is insufficient. Modifying Schwann cells to express "therapeutic" factors enhancing axonal regeneration and remyelination, such as cell adhesion molecules (14,15,51,69,71,76) or trophic factors (26,45), is a promising strategy to improve their capacity to repair the injured or demyelinated nervous system.…”

Section: Discussionmentioning

confidence: 99%

Baculovirus-Mediated Gene Delivery into Mammalian Cells Does Not Alter Their Transcriptional and Differentiating Potential but Is Accompanied by Early Viral Gene Expression

Kenoutis

Efrose

Swevers

et al. 2006

J Virol

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During the last decade, it has become apparent that baculoviruses not only represent a powerful expression system for production of recombinant proteins in insect cells but also can be used for transduction of dividing and nondividing mammalian cells and tissues in vitro, ex vivo, and in vivo (49). Advantages of the use of baculoviruses as gene delivery agents include their inability to replicate in mammalian cells, apparent lack of cytotoxicity, capacity to sustain large insertions of foreign DNA, ability to target many different cell types, and superior safety features relative to mammalian virus-based transduction systems (25,37,38,48). Thus, increasing interest for the development of recombinant baculoviruses as gene delivery vectors for use in human gene therapy exists.All baculovirus vectors for gene delivery in mammalian cells reported thus far have been based on the Autographa californica nuclear polyhedrosis virus (AcNPV). This is primarily due to the relatively wide host range of the virus and the multiplicity of lepidopteran cell lines in which it can be grown and propagated effectively as well as the availability of integrated methodologies allowing the rapid generation of recombinant viruses (55, 80). In contrast, there is a paucity of information regarding the suitability of other baculovirus species, particularly species with narrow host ranges to function as transduction vectors for mammalian cells.In this regard, it is also known that AcNPV has a propensity to express endogenous viral genes in nonhost insect species (12, 13). Moreover, studies involving transfection of mammalian cells with gene constructs employing baculovirus gene promoter elements have shown that certain early baculovirus promoters are marginally functional in mammalian cells and can also be activated by mammalian virus regulators (46, 66). These findings raise safety concerns related to the potential for low-level baculovirus gene expression in mammalian cells and the triggering of cellular immune responses against the transduced cells by the recipient host (61).In this work, we have explored the capacity of Bombyx mori NPV (BmNPV), the second best characterized baculovirus species after AcNPV (2,20,21,27,40,56,57,65), which has a very limited host range (58), to function as a transducing vector for mammalian cell lines and primary Schwann cells. The choice for the latter rests with the results of experimental transplantation in rodent and primate models, which has provided substantial evidence that Schwann cells are good candidates for cell therapy in human central nervous system (CNS) demyelinating diseases, such as multiple sclerosis, and trauma (5,6,9,19,26). Schwann cells provide trophic support and remyelinate demyelinated CNS axons. However, their integration in the CNS is limited. Therefore, modifying Schwann cells to express "therapeutic" factors enhancing axonal regeneration and remyelination by ex vivo gene transduction is a promising strategy to improve their capacity to repair the injured or demyelinated nervous ...

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“…RPTPz signaling has been implicated in the migration of astrocytes during development (Maeda et al, 1995) and in the migration of Schwann cells as well as osteoblasts (Thomaidou et al, 2001). More recently, RPTPz was shown to be the receptor for tenascin on glial tumor cells (Adamsky et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

A role for receptor tyrosine phosphataseζ in glioma cell migration

Müller¹,

Kunkel²,

et al. 2003

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Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases ζ/β as the putative F3 receptors on Schwann cells

Cited by 49 publications

References 57 publications

Inhibition of Glial Maturation byBone Morphogenetic Protein 2 in a Neural Crest-Derived Cell Line

Inhibition of Glial Maturation byBone Morphogenetic Protein 2 in a Neural Crest-Derived Cell Line

Baculovirus-Mediated Gene Delivery into Mammalian Cells Does Not Alter Their Transcriptional and Differentiating Potential but Is Accompanied by Early Viral Gene Expression

A role for receptor tyrosine phosphataseζ in glioma cell migration

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