Soluble L-selectin levels predict survival in sepsis

Seidelin, Jakob Benedict; Nielsen, Ole Haagen; Strøm, J.

doi:10.1007/s00134-002-1501-5

Cited by 51 publications

(44 citation statements)

References 26 publications

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“…Shedding of L-selectin has been shown in sepsisactivated neutrophils. Thus, high serum levels of L-selectin as a consequence of neutrophil shedding has been used as a predictor of severity of septic patients (25).…”

Section: Discussionmentioning

confidence: 99%

Acute-phase protein α-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism

Mestriner¹,

Spiller²,

Laure

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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The reduction of circulating neutrophil migration to infection sites is associated with a poor outcome of severe sepsis. ␣-1-Acid glycoprotein (AGP) was isolated from the sera of severely septic patients by HPLC and acrylamide gel electrophoresis and identified by mass spectrometry. Both the isolated protein and commercial AGP inhibited carrageenin-induced neutrophil migration into the rat peritoneal cavity when administered i.v. at a dose of 4.0 g per rat (95 pmol per rat). Analysis by intravital microscopy demonstrated that both proteins inhibited the rolling and adhesion of leukocytes in the mesenteric microcirculation. The inhibitory activity was blocked by 50 mg/kg aminoguanidine, s.c., and was not demonstrable in inducible nitric oxide synthase (iNOS) knockout mice. Incubation of AGP with neutrophils from healthy subjects induced the production of NO and inhibited the neutrophil chemotaxis by an iNOS/NO/cyclic guanosine 3,5-monophosphatedependent pathway. In addition, AGP induced the L-selectin shedding by neutrophils. The administration of AGP to rats with mild cecal ligation puncture sepsis inhibited neutrophil migration and reduced 7-day survival from Ϸ80% to 20%. These data demonstrate that AGP, an acute-phase protein, inhibits neutrophil migration by an NO-dependent process and suggest that AGP also participates in human sepsis.

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Section: Discussionmentioning

confidence: 99%

Acute-phase protein α-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism

Mestriner¹,

Spiller²,

Laure

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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“…On the contrary, low levels «470 ng/ml) of soluble L-selectin seem to predict poor prognosis and low rate of survival in patients with sepsis (56).…”

Section: Neutrophils Endothelial Dysfunction and Chemokines Lymphocymentioning

confidence: 97%

Perioperative Period: Immunological Modifications

Cardinale

Chinellato

Caimmi

et al. 2011

Int J Immunopathol Pharmacol

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Surgical stress induces complex modifications in the hemodynamic, metabolic, neuro-hormonal and immune response ofthe individual. The magnitude ofthese alterations depends on preoperative events leading to surgery, the severity of surgical trauma, and also on post-operative/post-traumatic complications ("multiple hit hypothesis"). As in other conditions of tissue damage, surgery trauma is followed by an immune-inflammatory response, initiated at the site of injury by the innate immune system, followed by a compensatory anti-inflammatory (or immunosuppressive) response (CARS), involving mainly cells of the adaptive immune system, which predispose the host to septic complications. The up-regulated inflammatory response, together with a profound impairment of macrophage and cell-mediated immunity, appear to be the cause for patients' increased susceptibility in developing subsequent sepsis after major surgery.

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“…Patients with low sL-selectin (<470 ng/mL) were characterized by a high 1-year mortality (Seidelin et al 2002).…”

Section: Selectins and Other Adhesion Moleculesmentioning

confidence: 99%

Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis?

2011

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Soluble L-selectin levels predict survival in sepsis

Abstract: Serum sL-selectin is a predictor of survival in patients with sepsis. Those admitted with low sL-selectin (<470 ng/ml) are characterized by a high mortality within the subsequent 12-month period.

Cited by 51 publications

References 26 publications

Acute-phase protein α-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism

Acute-phase protein α-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism

Perioperative Period: Immunological Modifications

Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis?

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