Soluble mediators in anti-fungal immunity

Dellière, Sarah; Wong, Sarah Sze Wah; Aimanianda, Vishukumar

doi:10.1016/j.mib.2020.05.005

Cited by 10 publications

(10 citation statements)

References 67 publications

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“…This can lead to invasive pulmonary aspergillosis (IPA), a fatal disease with high mortality rate (30–80%) ( Baddley et al, 2010 , Lortholary et al, 2011 , van de Veerdonk et al, 2017 , Wong, et al, 2021a ). Though the innate immune system consists of humoral immunity (which includes the complement system, collectins, immunoglobulins and antimicrobial peptides), their roles in the defence against A. fumigatus have been underexplored ( Dellière et al, 2020 , Parente, 2020 , Wong and Aimanianda, 2017 ). The diverse origin and functional overlap of humoral immune components warrant elucidation of their role in the host defence against A. fumigatus .…”

Section: Introductionmentioning

confidence: 99%

Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus

et al. 2022

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Highlights Surfactant protein D (SP-D), a C -type lectin and a major humoral immune component in the human lung-alveoli, shows direct growth inhibitory effect on Aspergillus fumigatus , an airborne opportunistic fungal pathogen. SP-D treatment modifies the surface architecture and cell wall polysaccharide exposure on the A. fumigatus hyphae. A. fumigatus hyphae grown in presence of SP-D stimulate significantly lower secretions of pro-inflammatory cytokine, but higher anti-inflammatory cytokine and chemokine secretions upon interaction with immune cells, compared to hyphae grown without SP-D. Increased permeability of A. fumigatus hyphae upon SP-D treatment leads to a better efficacy of voriconazole, an antifungal drug that has its target in the fungal cytosol.

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Section: Introductionmentioning

confidence: 99%

Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus

et al. 2022

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“…This may suggest that the lack of its binding partner to execute biological function may result in the observed increased PTX3 level in the Aspergillus+ BALF. CD11b and CD18, which form macrophage-1 antigen (complement receptor 3; CR3) that recognizes iC3b ( 2 ), were increased in the Aspergillus + BALF, suggesting their shedding. Other humoral factors abundant in Aspergillus + BALF were the antimicrobial molecules (neutrophil defensin-3, cathelicidin and galectin-10), may be to provide antifungal defense to some extent.…”

Section: Discussionmentioning

confidence: 99%

“…Although the cellular immune system against A. fumigatus is well studied, the role of humoral immune system against this fungus is an underexplored and/or a disregarded field. A better understanding of humoral components specifically implicated may both serve to develop new therapeutic strategies and to identify candidate host humoral markers of aspergillosis ( 2 ). A. fumigatus conidia entering lung-alveoli firstly interact with humoral components.…”

Section: Introductionmentioning

confidence: 99%

Proteomic Analysis of Humoral Immune Components in Bronchoalveolar Lavage of Patients Infected or Colonized by Aspergillus fumigatus

et al. 2021

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Humoral immune components have been individually studied in the context of interaction of host with Aspergillus fumigatus, a major airborne fungal pathogen. However, a global view of the multitude and complex nature of humoral immune components is needed to bring new insight into host-Aspergillus interaction. Therefore, we undertook comparative proteomic analysis of the bronchoalveolar lavage fluid collected from individuals infected or colonized with A. fumigatus versus controls, to identify those alveolar humoral components affected upon A. fumigatus infection. Complement proteins C1q, C8 beta-chain, factor-H, ficolin-1, ficolin-2, mannan binding lectin serine peptidase 2, pentraxin-3 and the surfactant protein-D were identified as the major humoral immune components affected by A. fumigatus infection and colonization. Based on this observation, we hypothesize that crosstalk between these humoral components is essential during host-Aspergillus interaction giving new specific leads to study for better understanding the pathogenesis. Furthermore, the affected humoral components could be potential diagnostic markers of A. fumigatus infection or colonization.

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“…Lactoferricin B helps to decrease the dosage of antifungal agents by 8 folds against biofilms formed by A. fumigatus, F. solani , or C. albicans . Another study reported that α defensins are known to show strong antifungal activity against A. fumigatus , C. neoformans, and C. albicans ( Delliere et al, 2020 ). Histatin -5 is a histidine-rich peptide which is produced by salivary glands in humans and higher primates ( Du et al, 2017 ).…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis

et al. 2021

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Microbial keratitis is a leading cause of blindness worldwide and results in unilateral vision loss in an estimated 2 million people per year. Bacteria and fungus are two main etiological agents that cause corneal ulcers. Although antibiotics and antifungals are commonly used to treat corneal infections, a clear trend with increasing resistance to these antimicrobials is emerging at rapid pace. Extensive research has been carried out to determine alternative therapeutic interventions, and antimicrobial peptides (AMPs) are increasingly recognized for their clinical potential in treating infections. Small molecules targeted against virulence factors of the pathogens and natural compounds are also explored to meet the challenges and growing demand for therapeutic agents. Here we review the potential of AMPs, small molecules, and natural compounds as alternative therapeutic interventions for the treatment of corneal infections to combat antimicrobial resistance. Additionally, we have also discussed about the different formats of drug delivery systems for optimal administration of drugs to treat microbial keratitis.

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Soluble mediators in anti-fungal immunity

Cited by 10 publications

References 67 publications

Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus

Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus

Proteomic Analysis of Humoral Immune Components in Bronchoalveolar Lavage of Patients Infected or Colonized by Aspergillus fumigatus

Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis

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