Soluble P-selectin as a marker of in vivo platelet activation

Ferroni, Patrizia; Martini, Francesca; Riondino, Silvia; Farina, Francesca; Magnapera, A.; Ciatti, Filippo

doi:10.1016/j.cca.2008.09.018

Cited by 105 publications

(89 citation statements)

References 26 publications

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“…The sample size did not allow for stratified analysis to control for a potential confounding effect of endothelial-derived sP-selectin on the correlation with CCN1. However, the combination of evidence suggesting that sP-selectin is primarily platelet-derived and our previous results demonstrating that platelets carry and release CCN1 suggests the risk of confounding to be limited [18,43]. Furthermore, It cannot be ruled out that blood loss, fluid replacement, or other factors, such as anesthesia, may have masked the responses of CCN1 to surgery.…”

Section: Discussionmentioning

confidence: 89%

Postoperative Accumulation of Cyr61/CCN1 in Surgical Wound Fluid Precedes Cytokine Activation and is Disparate from Systemic Alterations

Hviid¹,

Pripp²,

Aasen³

et al. 2014

J Infect Dis Ther

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Background: Cysteine-rich protein 61 (Cyr61/CCN1) is a multifunctional matricellular protein that has recently emerged as a potential player in injury-repair mechanisms involving the regulation of inflammatory responses. Experimental research has revealed the pro-inflammatory effects and chemotactic capacities of this protein, and clinical investigations have found it to be elevated in patients with chronic inflammatory conditions. However, its regulation at sites of acute tissue injury and inflammation in humans has not been investigated.

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Section: Discussionmentioning

confidence: 89%

Postoperative Accumulation of Cyr61/CCN1 in Surgical Wound Fluid Precedes Cytokine Activation and is Disparate from Systemic Alterations

Hviid¹,

Pripp²,

Aasen³

et al. 2014

J Infect Dis Ther

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“…To further support the role of platelets in the generation of CD34 ϩ /KDR ϩ in vivo, we compared the levels of soluble P-selectin (sP-sel) as a marker for in vivo platelet activation 17 in the placebo and aspirin-treated patients. Aspirin treatment did not affect the average values of sP-sel between the placebo and aspirin-treated groups (51.1Ϯ4.9 versus 54.3Ϯ6.0 ng/mL, respectively; Pϭ0.437; Figure 4C).…”

Section: /Kdrmentioning

confidence: 99%

Human CD34 ⁺ /KDR ⁺ Cells Are Generated From Circulating CD34 ⁺ Cells After Immobilization on Activated Platelets

Boer

Hovens²,

Oeveren‐Rietdijk³

et al. 2011

ATVB

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“…Once the arterial endothelium becomes injured, subendothelial components such as collagen [20] and von Willebrand factor [21] are exposed, resulting in the adherence of platelets to the damaged vessel wall and their subsequent activation. Activated platelets (P-selectinpositive platelets) release stromal cell-derived factor-1 (SDF-1) [22]. And co-cultivation experiments showed that human platelets recruit CD34-positive cells via specific adhesion receptors P-selectin/PSGL-1 and beta1-and beta2-integrins.…”

Section: Discussionmentioning

confidence: 99%

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2018

Oncotarget

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Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a crosssectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (≥ 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = −0.22, p = 0.019 for subjects with high hemoglobin, and β = −0.01, p = 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21, p = 0.037 and r = 0.40, p =< 0.001), but not in subjects with low hemoglobin (r = 0.04, p = 0.710 and r = 0.06, p = 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and circulating CD34-positive cells. These results indicate that subjects with a short stature activate vascular remodeling to a much greater extent than subjects with a tall stature.

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Soluble P-selectin as a marker of in vivo platelet activation

Cited by 105 publications

References 26 publications

Postoperative Accumulation of Cyr61/CCN1 in Surgical Wound Fluid Precedes Cytokine Activation and is Disparate from Systemic Alterations

Postoperative Accumulation of Cyr61/CCN1 in Surgical Wound Fluid Precedes Cytokine Activation and is Disparate from Systemic Alterations

Human CD34 ⁺ /KDR ⁺ Cells Are Generated From Circulating CD34 ⁺ Cells After Immobilization on Activated Platelets

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Soluble P-selectin as a marker of in vivo platelet activation

Cited by 105 publications

References 26 publications

Postoperative Accumulation of Cyr61/CCN1 in Surgical Wound Fluid Precedes Cytokine Activation and is Disparate from Systemic Alterations

Postoperative Accumulation of Cyr61/CCN1 in Surgical Wound Fluid Precedes Cytokine Activation and is Disparate from Systemic Alterations

Human CD34 + /KDR + Cells Are Generated From Circulating CD34 + Cells After Immobilization on Activated Platelets

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Human CD34 ⁺ /KDR ⁺ Cells Are Generated From Circulating CD34 ⁺ Cells After Immobilization on Activated Platelets