Soluble products of inflammatory reactions are not induced in children with asymptomatic <i>Plasmodium falciparum</i> infections

Jakobsen, Palle; Mckay, V.; Njie, Ramou; Olaleye, B.O.; D’Alessandro, Umberto; Bendtzen, Klaus; Schousboe, Inger; Greenwood, Brian

doi:10.1046/j.1365-2249.1996.d01-718.x

Cited by 15 publications

(12 citation statements)

References 11 publications

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“…In man, a role for aPL in antimalarial immunity has been proposed in several studies [6,14,15]. An attractive explanation consists of inhibition of mechanisms leading to TNF‐α production, especially during severe malaria [45,46]. In the present study, definite association was found between aPL and clinical/endemic statuses of donors.…”

Section: Discussionsupporting

confidence: 62%

High prevalence of co-factor independent anticardiolipin antibodies in malaria exposed individuals

Consigny¹,

Cauquelin

Agnamey³

et al. 2002

Clinical and Experimental Immunology

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SUMMARY Anticardiolipin antibodies (aCL) were investigated in 137 individuals chronically exposed to malaria and living in Africa and Asia. They belonged to several groups according to parasite (Plasmodium falciparum or vivax) and clinical manifestations (i.e. asymptomatic parasite carriers, acute uncomplicated attack or severe malaria episodes). aCL were measured in an enzyme immunoassay (ELISA) performed in the presence of either goat serum (aCLs) or gelatin (aCLg). In a group of 53 patients with autoimmune manifestations (i.e. antiphospholipid syndrome and/or lupus), detection of IgG but not IgM aCL was markedly reduced in the presence of gelatin. In malaria donors, high prevalence of serum co‐factor‐independent IgG and IgM were detected, and the presence of goat serum in the assay consistently decreased their detection. aCLg levels were found to be related to the clinical/endemic status of donors. IgG aCLg were found to be higher in asymptomatic P. falciparum carriers than in patients with uncomplicated acute or cerebral malaria. IgM aCLg were higher in the cerebral malaria group than in groups with uncomplicated acute malaria patients or asymptomatic individuals. Data suggest that using a serum co‐factor independent, sensitive ELISA, aCL are commonly detected during malarial infections and related to malarial infection status.

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Section: Discussionsupporting

confidence: 62%

High prevalence of co-factor independent anticardiolipin antibodies in malaria exposed individuals

Consigny¹,

Cauquelin

Agnamey³

et al. 2002

Clinical and Experimental Immunology

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“…Typically, they were found elevated in long-term exposed subjects and in acute symptomatic infection, while asymptomatic infection has rarely been studied. However, phospholipid-related specificities were found more elevated in asymptomatics than in patients with malaria symptoms [29,30]. All these previous studies focused on antibody specificities otherwise known from autoimmune disease conditions, particularly systemic lupus erythematosus.…”

Section: Discussionmentioning

confidence: 99%

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Fesel

Goulart

Neto

et al. 2005

Malar J

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“…In children with acute disease, the concentrations of TNF-␣, IL-12, and IL-10 in plasma did not correlate with each other. The plasma concentration of IL-10 was positively correlated with parasitemia (14) and the number of BDCA3 ϩ mDCs in children with acute malaria (Pearson correlation coefficient: parasitemia, r ϭ 0.794, P Ͻ 0.001; BDCA3 ϩ mDC, r ϭ 0.393, P Ͻ 0.05). The concentration of IL-12 or TNF-␣ in plasma did not correlate with the absolute number of or HLA DR expression on any of the DC subsets or monocytes.…”

Section: Frequency Of Peripheral Blood DC Subsetsmentioning

confidence: 98%

The Frequency of BDCA3-Positive Dendritic Cells Is Increased in the Peripheral Circulation of Kenyan Children with Severe Malaria

et al. 2006

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The ability of Plasmodium falciparum-infected erythrocytes to adhere to host endothelial cells via receptor molecules such as ICAM-1 and CD36 is considered a hallmark for the development of severe malaria syndromes. These molecules are also expressed on leukocytes such as dendritic cells. Dendritic cells are antigen-presenting cells that are crucial for the initiation of adaptive immune responses. In many human diseases, their frequency and function is perturbed. We analyzed the frequency of peripheral blood dendritic cell subsets and the plasma concentrations of interleukin-10 (IL-10) and IL-12 in Kenyan children with severe malaria and during convalescence and related these parameters to the adhesion phenotype of the acute parasite isolates. The frequency of CD1c ؉ dendritic cells in children with acute malaria was comparable to that in healthy controls, but the frequency of BDCA3 ؉ dendritic cells was significantly increased. Analysis of the adhesion phenotypes of parasite isolates revealed that adhesion to ICAM-1 was associated with the frequency of peripheral blood CD1c ؉ dendritic cells, whereas the adhesion of infected erythrocytes to CD36 correlated with high concentrations of IL-10 and low concentrations of IL-12 in plasma.

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Soluble products of inflammatory reactions are not induced in children with asymptomatic Plasmodium falciparum infections

Cited by 15 publications

References 11 publications

High prevalence of co-factor independent anticardiolipin antibodies in malaria exposed individuals

High prevalence of co-factor independent anticardiolipin antibodies in malaria exposed individuals

Untitled

The Frequency of BDCA3-Positive Dendritic Cells Is Increased in the Peripheral Circulation of Kenyan Children with Severe Malaria

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