Soluble Suppression of Tumorigenicity 2 and Echocardiography in Sepsis

Yang, Hyun Suk; Hur, Mina; Kim, Hyeong-Su; Magrini, L.; Marino, Rossella; Somma, Salvatore Di

doi:10.3343/alm.2016.36.6.590

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…Multiple organ failure is a complex syndrome involving diverse pathways and pathological processes in sepsis [2425]. Cardiac failure is a major risk factor of in-hospital mortality [26]. In addition, cardiac and renal diseases interact in a complex bidirectional and interdependent manner in both acute and chronic settings; sepsis is a representative disease entity of the organ crosstalk between the heart and kidney [24].…”

Section: Discussionmentioning

confidence: 99%

Circulating Biologically Active Adrenomedullin Predicts Organ Failure and Mortality in Sepsis

Kim

Hur

Struck³

et al. 2019

Ann Lab Med

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Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Biologically active adrenomedullin (bio-ADM) is an emerging biomarker for sepsis. We explored whether bio-ADM concentration could predict severity, organ failure, and 30-day mortality in septic patients. Methods In 215 septic patients (109 patients with sepsis; 106 patients with septic shock), bio-ADM concentration was measured at diagnosis of sepsis, using sphingotest bio-ADM (Sphingotec GmbH, Hennigsdorf, Germany) and analyzed in terms of sepsis severity, vasopressor use, and 30-day mortality. The number of organ failures, sequential (sepsis-related) organ failure assessment (SOFA) score, and 30-day mortality were compared according to bio-ADM quartiles. Results Bio-ADM concentration was significantly higher in patients with septic shock, vasopressor use, and non-survivors than in patients with solitary sepsis, no vasopressor use, and survivors, respectively (all P <0.0001). Bio-ADM quartiles were associated with the number of organ failures ( P <0.0001), as well as SOFA cardiovascular, renal, coagulation, and liver subscores (all P <0.05). The 30-day mortality rate showed a stepwise increase in each bio-ADM quartile (all P <0.0001). Bio-ADM concentration and SOFA score equally predicted the 30-day mortality (area under the curve: 0.827 vs 0.830). Conclusions Bio-ADM could serve as a useful and objective biomarker to predict severity, organ failure, and 30-day mortality in septic patients.

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Section: Discussionmentioning

confidence: 99%

Circulating Biologically Active Adrenomedullin Predicts Organ Failure and Mortality in Sepsis

Kim

Hur

Struck³

et al. 2019

Ann Lab Med

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“…Meta-analysis study performed by Aimo et al (2017) mentioned that plasma sST2 has prognostic value with respect to all-cause and cardiovascular death [31], and associated with cardiac concentric hypertrophy in patients with metabolic syndrome [32]. Circulating sST2 levels also correlate with a worse phenotype of disease including adverse remodeling and fibrosis, cardiac dysfunction, impaired hemodynamics and higher risk of progression [33,34]. Therefore, it was supposed that plasma level of sST2 would increase in the early stage of LHV.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, in a meta-analysis plasma sST2 has been demonstrated to have a prognostic value with respect to all-cause and cardiovascular death as well as the composite outcome of all-cause death or HF hospitalization [33]. Previous studies already also have shown that plasma sST2 was not only useful biomarker for predicting development of stress cardiomyopathy [34] but also has prognostic role in patients with sepsis [35,36] and correlated with left ventricular structure and function in patients with metabolic syndrome [37]. Renin is the well-known enzyme of the Renin Angiotensin Aldosteron System, which plays central role in the regulation of blood pressure and the development of LVH [12,13].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of sST-2 Role in LVH Regression Obtained in Hypertensive Mice Models After Blocking Renin-Angiotensin System

Yusetyani¹,

Rofida²,

Lestari³

et al. 2019

JTLS

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Soluble ST2, is a protein which acts as a decoy receptor for interleukin-33, and served as biomarker associated with left ventricular hypertrophy (LVH). Few data exist in evaluating the effects of anti-hypertensive agents on the role-played form ST2 on regression of LVH. This study was designed to compare the effects of captopril and valsartan on blood pressures, plasma renin and soluble ST2 levels and regression of LVH in hypertensive mice models. Twenty-four male mice (Mus musculus L), were divided into four groups, namely aquadest/control, L-NAME, L-NAME + captopril and L-NAME + valsartan groups respectively. Mice blood pressures were measured on day 14th after induction with L-NAME extract 1.75 mg/25g BW/day (pretreatment) and day 14th post treatment. Levels of plasma renin, sST2, and ventricular wall thicknesses reflecting LVHs, were measured on day 14th post treatment. Administration of L-NAME within 14 days resulted in making mice models to be hypertensive paralleled by an increase of Ventricular wall thickness. Treatment with captopril and valsartan lowered the blood pressures to normal level within the next 14 days. Valsartan and captopril treatment induced a significant decrease of plasma renin level. Valsartan, but not for captopril treatment prevented wall thickness increase (p < 0.05), while plasma sST2 was not able to mirroring this effect. Captopril and valsartan had similar effect in lowering plasma renin level and blood pressure, but sST2 seems to be not involved in LVH regression obtained in hypertensive mice models after blocking renin-angiotensin system.

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“…However, findings on sST2 in sepsis have been ambiguous. The study of Yang et al reported that sST2 levels were not associated with cardiac function in septic patients ( 18 ). Studies determining the relationship between sST2 and SIC to predict prognosis in affected patients should be conducted.…”

Section: Introductionmentioning

confidence: 99%

Testosterone and soluble ST2 as mortality predictive biomarkers in male patients with sepsis-induced cardiomyopathy

Wang,

Dai,

Zhu

et al. 2024

Front. Med.

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Sepsis-induced cardiomyopathy (SIC) is characterized by high mortality and poor outcomes. This study aimed to explore the relationship between testosterone and soluble ST2 (sST2) and all-cause mortality in patients with SIC. Clinical data from SIC patients at Renmin Hospital of Wuhan University from January 2021 and March 2023 were reviewed. Serum testosterone and sST2 were measured at admission. Kaplan–Meier analysis and receiver operative characteristic curve (ROC) were used to estimate the predictive values of testosterone and sST2 on 28 days and 90 days mortality of SIC. A total of 327 male subjects with SIC were enrolled in this study. During the 28 days and 90 days follow-up, 87 (26.6%) and 103 deaths (31.5%) occurred, respectively. Kaplan–Meier analysis showed significantly higher 28 days and 90 days survival in patients with higher testosterone and decreased sST2 levels (p < 0.001). Testosterone, sST2, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were significantly associated with 28 days and 90 days mortality (p < 0.05). Partial correlation analysis showed strong positive correlation between testosterone and left ventricular ejection fraction (LVEF) (p < 0.001), and negative correlation between testosterone and sST2 (p < 0.001), high-sensitivity troponin I (hs-TnI) levels (p < 0.001) and smoke history (p < 0.01). The concentrations of sST2 were positively related with E/e′ ratio (p < 0.001), and negatively correlated with TAPSE (p < 0.001). The combination of testosterone and sST2 enhanced the prediction of both 28 days [area under the ROC curve (AUC), 0.805] and 90 days mortality (AUC, 0.833). Early serum testosterone and sST2 levels could predict mortality of SIC independently and jointly. Further research is needed to determine the utility of biochemical markers in identifying high-risk patients with SIC.

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Soluble Suppression of Tumorigenicity 2 and Echocardiography in Sepsis

Cited by 5 publications

References 21 publications

Circulating Biologically Active Adrenomedullin Predicts Organ Failure and Mortality in Sepsis

Circulating Biologically Active Adrenomedullin Predicts Organ Failure and Mortality in Sepsis

Evaluation of sST-2 Role in LVH Regression Obtained in Hypertensive Mice Models After Blocking Renin-Angiotensin System

Testosterone and soluble ST2 as mortality predictive biomarkers in male patients with sepsis-induced cardiomyopathy

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