1999
DOI: 10.1016/s0168-8278(99)80060-9
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Soluble tumor necrosis factor receptors in chronic hepatitis C: a correlation with histological fibrosis and activity

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Cited by 171 publications
(110 citation statements)
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“…This down-regulation is paralleled by a marked increase in both sTNFR serum levels. Elevated serum levels of soluble TNFRs, especially TNFR2 have often been described to correlate with TNF serum levels and disease activity in acute and chronic liver disease (i.e., hepatitis B or C or autoimmunohepatitis) in humans (8,9,11,28,29), which might point to a desensitizing mechanism, that protects hepatocytes from the high local levels of TNF. The contradictory observations between carbon tetrachloride-and Con A-induced liver injury are not yet clear, but it seems likely that the T cell mitogen Con A induces a different local cytokine milieu, thereby inducing a distinct transcriptional regulation of TNFR mRNA expression in hepatic tissue.…”
Section: Discussionmentioning
confidence: 99%
“…This down-regulation is paralleled by a marked increase in both sTNFR serum levels. Elevated serum levels of soluble TNFRs, especially TNFR2 have often been described to correlate with TNF serum levels and disease activity in acute and chronic liver disease (i.e., hepatitis B or C or autoimmunohepatitis) in humans (8,9,11,28,29), which might point to a desensitizing mechanism, that protects hepatocytes from the high local levels of TNF. The contradictory observations between carbon tetrachloride-and Con A-induced liver injury are not yet clear, but it seems likely that the T cell mitogen Con A induces a different local cytokine milieu, thereby inducing a distinct transcriptional regulation of TNFR mRNA expression in hepatic tissue.…”
Section: Discussionmentioning
confidence: 99%
“…Rather, IR in CHC seems to be due to direct virus-specific effects on insulin signaling. Thus, initial studies noted increased serum levels of TNF-α in subjects with CHC [66][67][68] or showed a correlation with IR [69] but did not adequately correct for potential confounders. A later well-controlled study compared 154 HCV-infected non-diabetic males with 75 matched uninfected controls [65] .…”
Section: Inflammation and Irmentioning
confidence: 99%
“…In its function as a receptor for the proinflammatory cytokine TNF-a, sTNF-R2 has been shown in many studies to be directly associated with HCV-related chronic hepatitis and histologic fibrosis (27,28,42). Itoh et al (43) reported high correlations between sTNF-R2 and several liver disease markers (e.g., alanine aminotransferase, aspartate aminotransferase, and g-glutamyl transpeptidase) as well as with Knodell's histologic activity index score in HCV chronically infected subjects.…”
Section: Discussionmentioning
confidence: 99%
“…The type 1/type 2 cytokine balance in sera, liver tissue, and culture supernatant of lymphocytes has been studied extensively in HCV-infected patients, but inconsistent results have failed to provide definitive information about the role of cytokines in HCV disease pathology (13)(14)(15)(22)(23)(24)(25)(26)(27)(28)(29). Nevertheless, data from several studies suggest that a dysregulation of the host immune status may be important in the progression of HCV-related liver disease (14,(22)(23)(24)(25).…”
Section: Introductionmentioning
confidence: 99%
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