Soluble vascular cell adhesion molecule-1 (VCAM-1) in the serum of patients with atopic dermatitis

Chun, Woo Hyung; Lee, H.J.; Lee, K.H.

doi:10.1111/j.1365-2133.1997.tb08767.x

Cited by 2 publications

(2 citation statements)

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“…It was clearly shown in previous studies that other adhesion molecules, such as E-selectin, ICAM-1 and VCAM-1, partake in the migration process of lymphocytes [12,13,33] . Moreover, several studies indicated a strict correlation between the serum concentration of these molecules and the severity of AE [12,13] .…”

Section: Discussionmentioning

confidence: 99%

Expression of Vascular Adhesion Protein-1 in Atopic Eczema

Reich¹,

Orda²,

Szepietowski³

2006

Int Arch Allergy Immunol

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Background:Vascular adhesion protein-1 (VAP-1) is an adhesion molecule with an enzymatic activity which partakes in the migration process of lymphocytes. The aim of this study was to investigate VAP-1 expression in atopic eczema (AE) in comparison with healthy controls and psoriatic individuals. Material and Methods:Forty adult patients suffering from AE aged between 18 and 56 years were included in the study. The control group consisted of 35 healthy volunteers aged between 19 and 49 years and of 71 psoriatic patients aged between 23 and 89 years. The serum concentration of soluble VAP-1 (sVAP-1) was evaluated by ELISA and VAP-1 expression in the skin by immunohistochemistry. Results: Serum level of sVAP-1 in AE patients before treatment was significantly higher compared with healthy volunteers. Similarly, a higher mean number of VAP-1-positive vessels was found in both lesional and nonlesional atopic skin compared with healthy skin. Treatment of AE resulted in a significant reduction in the serum level of sVAP-1. On the other hand, both the serum level of sVAP-1 and the number of dermal vessels with expression of VAP-1 were significantly lower in AE patients compared with psoriatic individuals. Conclusion: This study indicates the important role of VAP-1 in the pathogenesis of chronic inflammatory cutaneous disorders, including AE.

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Section: Discussionmentioning

confidence: 99%

Expression of Vascular Adhesion Protein-1 in Atopic Eczema

Reich¹,

Orda²,

Szepietowski³

2006

Int Arch Allergy Immunol

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“…Since the late 1990s, there have been many attempts to find biomarker candidates. In the early years, most studies concentrated on endothelial cell adhesion molecules, 50 , 51 , 52 , 53 , 54 and works on chemokines were published in 2000. 55 , 56 , 57 , 58 Brief summary on history of biomarker studies are summarized in Table 2 .…”

Section: Introductionmentioning

confidence: 99%

Specific Immunotherapy in Atopic Dermatitis

Lee

Park

Lee

2015

Allergy Asthma Immunol Res

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Allergen specific immunotherapy (SIT) using house dust mite (HDM) extracts has been performed mainly with patients of asthma and allergic rhinitis. In the meanwhile, there has been a long debate on the efficacy of SIT in atopic dermatitis (AD) with only a few double-blind placebo-controlled trials. However, several randomized controlled trials of SIT in AD revealed significant improvement of clinical symptoms and also, positive result was shown by a following meta-analysis study of these trials. In order to predict and evaluate the treatment outcome, finding a biomarker that can predict treatment responses and treatment end-points is critical but it is very challenging at the same time due to the complexity of causes and mechanisms of AD. Other considerations including standardization of the easiest and safest treatment protocol and optimizing the treatment preparations should be studied as well. This review summarizes the basics of SIT in AD including the brief mechanisms, treatment methods and schedules, and also highlights the clinical efficacy of SIT in AD along with mild, controllable adverse reactions. Immunologic effects and studies of various biomarkers are also introduced and finally, future considerations with upcoming studies on SIT were discussed.

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Soluble vascular cell adhesion molecule-1 (VCAM-1) in the serum of patients with atopic dermatitis

Cited by 2 publications

References 8 publications

Expression of Vascular Adhesion Protein-1 in Atopic Eczema

Expression of Vascular Adhesion Protein-1 in Atopic Eczema

Specific Immunotherapy in Atopic Dermatitis

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