Soluble vascular cell adhesion molecule-1 and E-selectin levels in relation to vascular risk factors and to E-selectin genotype in the first degree relatives of NIDDM patients and in NIDDM patients

Bannan, Sally; Mansfield, Michael W.; Grant, Peter J.

doi:10.1007/s001250050930

Cited by 81 publications

(58 citation statements)

References 31 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although we did find a moderately strong association between sVCAM-1 and CRP levels, we showed that the association between sVCAM-1 levels and risk of cardiovascular mortality was independent of CRP levels, suggesting that sVCAM-1 levels increase cardiovascular risk through a pathway different from that of an acute phase response. Third, increased levels of sVCAM-1 could reflect generalized endothelial d y s f u n c t i o n , since we and others showed high sVCAM-1 levels to be associated with high vWF levels (18,22,31) and the presence of microalbuminuria (18), i.e., potential markers of generalized endothelial dysfunction (42)(43)(44). However, we showed sVCAM-1 levels to be associated with the risk of cardiovascular mortality independent of vWF levels and of microalbuminuria, which argues against the idea of increased sVCAM-1 levels being a marker of generalized endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 86%

“…Most (20,(25)(26)(27)(28)(29), but not all (30,31), studies have shown sVCAM-1 levels to be increased among type 2 diabetic subjects as compared with nondiabetic subjects, and sVCAM-1 levels have been shown to be independently associated with carotid artery intima-media thickness in type 2 diabetes patients (29). In view of these considerations, we investigated the association of sVCAM-1 concentration and risk of cardiovascular and all-cause mortality among nondiabetic and type 2 diabetic subjects in a prospective, populationbased cohort study.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study.

et al. 2000

View full text Add to dashboard Cite

Membrane-bound vascular cell adhesion molecule 1 (VCAM-1) allows the tethering and rolling of monocytes and lymphocytes as well as firm attachment and transendothelial migration of leukocytes. Soluble forms of VCAM (sVCAM-1) may serve as monitors of increased expression of membrane-bound VCAM-1 and thus may reflect progressive formation of atherosclerotic lesions. Levels of sVCAM-1 have been found to be increased among type 2 diabetic as compared with nondiabetic subjects. To study the association of plasma sVCAM-1 concentration and risk of cardiovascular and all-cause mortality among nondiabetic and diabetic subjects, we investigated an age-, sex-, and glucose-tolerance-stratified sample (n = 631) of a populationbased cohort aged 50-75 years that was followed p r o s p e c t i v e l y. Plasma levels of sVCAM-1 were determined in frozen -70°C baseline samples. After 7.4 years (mean) of follow-up, 107 (17%) subjects had died ( 4 2 of cardiovascular causes). In the entire group, increased sVCAM-1 levels were significantly associated with increased risk of cardiovascular mortality (relative risks [RRs] per 100 ng/ml sVCAM-1 increase, 1.10 [1.05-1.15] after adjustment for age, sex, and glucose tolerance status). This RR was somewhat diminished by further adjustment for the presence of hypertension and cardiovascular disease; levels of total, HDL, and LDL cholesterol and homocysteine; the presence of microalbuminuria (a putative marker of endothelial dysfunction); levels of von Willebrand factor (a marker of endothelial dysfunction) and C-reactive protein (a marker of low-grade inflammation); and estimates of glomerular filtration rate. However, the RR remained statistically significant. The RR among type 2 diabetic subjects was 1.13 (1.07-1.20) per 100 ng/ml sVCAM-1 increase after adjustment for age and sex, which was somewhat higher but not significantly different from the RR in nondiabetic subjects (P value for interaction term, 0.12). Further adjustment for other risk factors gave similar results. In conclusion, levels of sVCAM-1 are independently associated with the risk of cardiovascular mortality in type 2 diabetic subjects and therefore might be useful for identifying subjects at increased cardiovascular risk. Increased plasma sVCAM-1 levels may reflect progressive formation of atherosclerotic lesions, or sVCAM-1 itself may have bioactive properties related to cardiovascular risk. Our data, however, argue against the hypotheses of sVCAM-1 levels simply being a marker of endothelial dysfunction, of low-grade inflammation, or of an impaired renal function. D i a b e t e s 4 9 :4 8 5-491, 2000

show abstract

Section: Discussionmentioning

confidence: 86%

mentioning

confidence: 99%

Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study.

et al. 2000

View full text Add to dashboard Cite

show abstract

“…Moreover, an association of E-selectin concentrations with HbA 1 c values in patients with Type I diabetes [4,5] and with Type II diabetes [8] has been found. However, other recent studies could not detect a relation between AM concentrations and glycaemic control [9,24]. These conflicting results could be explained by differences in the degree of glycaemic control between these different study cohorts [4,24].…”

Section: Discussionmentioning

confidence: 88%

“…However, other recent studies could not detect a relation between AM concentrations and glycaemic control [9,24]. These conflicting results could be explained by differences in the degree of glycaemic control between these different study cohorts [4,24]. The influence of the glycaemic control on plasma AM concentrations is further suggested by results showing that the association between HbA 1 c and E-selectin disappeared after improvement of glycaemic control [8].…”

Section: Discussionmentioning

confidence: 96%

Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes

et al. 2002

View full text Add to dashboard Cite

Patients with Type II (non-insulin-dependent) diabetes mellitus have an increased risk for premature atherosclerosis [1,2]. Increased concentrations of plasma adhesion molecules (AM) have been detected in patients with developing atherosclerosis [3] and in patients with Type I (insulin-dependent) diabetes mellitus [4,5] and Type II diabetes [6±9]. Moreover, increased plasma concentrations of soluble forms of some of these adhesion molecules have been suggested as markers of early atherosclerosis [10,11]. These Diabetologia (2002) with the other groups. The adhesion molecule concentrations correlate with the fasting plasma glucose (r = 0.59, p < 0.001), the 2-h OGTT plasma glucose (r = 0.70, p < 0.01), and the HbA 1 c value (r = 0.61, p < 0.05). The E-selectin but not the ICAM-1 and VCAM-1 plasma concentrations correlated with the fasting insulin concentrations (r = 0.62, p < 0.05) or the whole body glucose uptake (r = 0.59, p < 0.05) in the clamp. The hyperinsulinaemia during the euglycaemic hyperinsulinaemic clamp had no significant effect on the plasma concentrations of E-selectin, ICAM-1, and VCAM-1 in all three groups. Conclusion/interpretation. Our results suggest that increased E-selectin concentrations are related to hyperglycaemia, hyperinsulinaemia and insulin resistance, whereas increased ICAM-1 and VCAM-1 plasma concentrations in patients with Type II diabetes are rather related to hyperglycaemia than to hyperinsulinaemia or insulin resistance. [Diabetologia (2002) 45: 210±216]

show abstract

“…In particular, there was no effect of the 561A4C polymorphism in contrast to a weak association reported in UK patients with type 2 diabetes mellitus. 46 This may be a population or disease-specific association.…”

Section: Discussionmentioning

confidence: 99%

No association between E- and L-selectin genes and SLE: soluble L-selectin levels do correlate with genotype and a subset in SLE

et al. 2005

View full text Add to dashboard Cite

Altered function of selectin glycoprotein adhesion molecules may modulate severity and organ-specific manifestations of autoimmune and inflammatory disease via changes in leukocyte trafficking. Serum concentrations of selectin molecules have been suggested as useful biomarkers in systemic lupus erythematosus (SLE). We identified increased levels of soluble L-selectin (sL-selectin), but not soluble E-selectin (sE-selectin) in 278 European-Caucasian lupus patients compared to 230 healthy siblings (P ¼ 0.002). sL-selectin levels were markedly elevated in patients with IgG antiphospholipid autoantibodies (P ¼ 0.002), suggesting that perhaps sL-selectin defines a subgroup of lupus with vasculopathy. sL-selectin level was also influenced by two L-selectin polymorphisms: 665C4T, F206L in the epidermal growth factor-like domain (P ¼ 0.015) and rs12938 in the 3 0 -untranslated region (P ¼ 0.06). Having shown increased sL-selectin levels in lupus patients, we used genetics to investigate whether this was a secondary phenomena or the result of an underlying genetic mechanism. The inheritance of nine single-nucleotide polymorphisms (SNP) spanning the selectin locus was tested in 523 UK simplex SLE families. No association with SLE, or related phenotypes, was evident with any single SNP, or haplotype in family-based tests of association. Selectin polymorphisms are, therefore, unlikely to be independent factors in SLE susceptibility.

show abstract

Soluble vascular cell adhesion molecule-1 and E-selectin levels in relation to vascular risk factors and to E-selectin genotype in the first degree relatives of NIDDM patients and in NIDDM patients

Cited by 81 publications

References 31 publications

Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study.

Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study.

Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes

No association between E- and L-selectin genes and SLE: soluble L-selectin levels do correlate with genotype and a subset in SLE

Contact Info

Product

Resources

About