Soluble Vascular Endothelial Growth Factor Receptor 1 in Tracheal Aspirate Fluid of Preterm Neonates at Birth May Be Predictive of Bronchopulmonary Dysplasia/Chronic Lung Disease

Hasan, Jamal; Beharry, Kay D.; Valencia, Arwin M.; Strauss, Arthur; Modanlou, Houchang D.

doi:10.1542/peds.2008-1670

Cited by 34 publications

(25 citation statements)

References 29 publications

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“…Inhibition of VEGF during lung development results in disruption of vascular and alveolar development and a pathologic picture similar to that of new BPD (8). Thus, the lower initial VEGF concentrations found in our study in infants eventually developing BPD could well reflect a mechanistic process of adverse lung development and are in agreement with previous human studies (22,23). BALF VEGF levels may be used to identify individuals at particular risk for BPD at an early stage, which could facilitate future implementation of individualized preventive strategies for BPD in preterm infants.…”

Section: Discussionsupporting

confidence: 89%

Early Alterations of Growth Factor Patterns in Bronchoalveolar Lavage Fluid From Preterm Infants Developing Bronchopulmonary Dysplasia

Been

Debeer²,

Iwaarden

et al. 2010

Pediatr Res

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Chronic lung disease of prematurity (bronchopulmonary dysplasia; BPD) is characterized by an arrest in lung development. We hypothesized that early alterations in pulmonary expression of growth factors important for normal lung development would precede development of BPD. Bronchoalveolar lavage fluid (BALF) was obtained from ventilated preterm infants (n ϭ 62) on postnatal d 0, 1, 3, and 7 and analyzed for total phospholipids (PL), VEGF, PDGF-BB, TGF-␣ and -␤1, granulocyte macrophage colony stimulating factor (GM-CSF), and keratinocyte growth factor (KGF). Levels (Ln transformed) were compared between infants developing BPD and BPD-free survivors, adjusted for potential confounders.

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Section: Discussionsupporting

confidence: 89%

Early Alterations of Growth Factor Patterns in Bronchoalveolar Lavage Fluid From Preterm Infants Developing Bronchopulmonary Dysplasia

Been

Debeer²,

Iwaarden

et al. 2010

Pediatr Res

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“…VEGFR-1 is the respective tyrosine kinase receptor needed for VEGF to act physiologically (20,23,24,33). sVEGFR-1 is the splice variant of the VEGFR-1, which acts as a VEGF "trap" (21).…”

Section: Discussionmentioning

confidence: 99%

“…Tambunting et al (23) have shown that VEGF and VEGF receptor mRNA expression are impaired in lungs of extremely preterm baboons developing BPD, contributing to the dysmorphic microvasculature and disrupted alveolarization. Furthermore, Hasan et al (24) showed that VEGF levels are low and soluble VEGF receptor (sVEGFR)-1 levels are high at birth in the tracheal aspirates of preterm newborn infants who developed BPD later, suggesting that sVEGFR-1, the endogenous inhibitor of VEGF, may be a biological marker for BPD.…”

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confidence: 99%

Response of vascular endothelial growth factor and angiogenesis-related genes to stepwise increases in inspired oxygen in neonatal rat lungs

et al. 2013

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Background: Bronchopulmonary dysplasia is an inflammatory lung disease that afflicts preterm infants requiring supplemental oxygen and is associated with impaired pulmonary angiogenesis. We tested the hypothesis that there is a critical threshold of inspired O 2 (FiO 2 ) that alters pulmonary angiogenesis. Methods: Within 2-6 h of birth, rat pups were exposed to 10%, 21%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 100% FiO 2 for 2 h. Mixed arterial-venous blood gases, serum and pulmonary levels of vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1, and pulmonary angiogenesis gene profiles were determined. results: Po 2 increased with hyperoxia from 35.6 ± 5.0 (range: 31.5-39.8) at 10% O 2 to 108.5 ± 25.0 (range: 82.2-134.8) at 100% O 2 . Po 2 at 21% O 2 was 42. 4 ± 7.3 (range: 36.8-48

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“…Infants with BPD have reduced lung volumes and defective gas exchange (26) and can develop pulmonary hypertension (33). Previous studies measuring vascular growth factors in the lungs of patients developing BPD have reported conflicting results (2,12,20,29,30). Some insights into lung vascular pathology in BPD have come from biopsy and autopsy specimens (13).…”

mentioning

confidence: 99%

Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines

Miller

Benjamin

Kelly³

et al. 2010

American Journal of Physiology-Lung Cellular and Molecular Phys

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The fetal lung vasculature forms in tandem with developing airways. Whereas saccular airway morphogenesis is arrested in bronchopulmonary dysplasia (BPD), the potential vascular phenotype in BPD at this stage of development is less well-understood. As inflammation increases the risk of BPD and induces arrest of saccular airway morphogenesis, we tested the effects of Escherichia coli LPS on fetal mouse lung vascular development. Injecting LPS into the amniotic fluid of Tie2-lacZ endothelial reporter mice at embryonic day 15 stimulated angiogenesis in the saccular stage fetal lung mesenchyme. LPS also increased the number of endothelial cells in saccular stage fetal mouse lung explants. Inflammation appeared to directly promote vascular development, as LPS stimulated pulmonary microvascular endothelial cell angiogenesis, cell migration, and proliferation in vitro. Whereas LPS did not increase expression of VEGF, angiopoietin-1 (Ang-1), Tie2, fetal liver kinase-1 (Flk-1), fms-like tyrosine kinase-1 (Flt-1), PDGFA, PDGFB, heparin-binding EGF-like growth factor (HB-EGF), or connective tissue growth factor (CTGF), LPS did stimulate the production of the angiogenic CC chemokines macrophage inflammatory protein-1α (MIP-1α) and monocyte chemoattractant protein-1 (MCP-1). Both MIP-1α and MCP-1 increased angiogenesis in fetal mouse lung explants. In addition, inhibitory antibodies against MIP-1α and MCP-1 blocked the effects of LPS on fetal lung vascular development, suggesting these chemokines are downstream mediators of LPS-induced angiogenesis. We speculate that an inflammation-mediated surge in angiogenesis could lead to formation of aberrant alveolar capillaries in the lungs of patients developing BPD.

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Soluble Vascular Endothelial Growth Factor Receptor 1 in Tracheal Aspirate Fluid of Preterm Neonates at Birth May Be Predictive of Bronchopulmonary Dysplasia/Chronic Lung Disease

Cited by 34 publications

References 29 publications

Early Alterations of Growth Factor Patterns in Bronchoalveolar Lavage Fluid From Preterm Infants Developing Bronchopulmonary Dysplasia

Early Alterations of Growth Factor Patterns in Bronchoalveolar Lavage Fluid From Preterm Infants Developing Bronchopulmonary Dysplasia

Response of vascular endothelial growth factor and angiogenesis-related genes to stepwise increases in inspired oxygen in neonatal rat lungs

Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines

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