Solute solubility as criterion for the appearance of amorphous particle precipitation or crystallization in the supercritical antisolvent (SAS) process

Rossmann, Matthias; Braeuer, Andreas; Dowy, Stefan; Gallinger, Thomas Gottfried; Leipertz, Alfred; Schluecker, Eberhard

doi:10.1016/j.supflu.2011.11.023

Cited by 55 publications

(27 citation statements)

References 29 publications

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“…They have been successfully applied in several fields such as the micronization of several kind of materials [13][14][15][16][17][18][19][20], extraction of natural matter [21], impregnation of metals or drugs in aerogels [22,23], membranes [24] and scaffolds production [25,26]. Among supercritical assisted micronization techniques, Supercritical antisolvent (SAS) precipitation has been successfully used to obtain microparticles and nanoparticles of several kinds of compounds, such as pharmaceuticals, coloring matters, polymers and biopolymers [27][28][29][30][31][32][33][34][35][36]. In some of them [27,28], SAS mechanisms (related to fluid-dynamics, thermodynamics and mass transfer aspects) and their interactions, leading to the formation of micro and nanoparticles, have been investigated.…”

Section: Introductionmentioning

confidence: 99%

Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

Prosapio

Marco

Scognamiglio

et al. 2015

Chemical Engineering Journal

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Section: Introductionmentioning

confidence: 99%

Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

Prosapio

Marco

Scognamiglio

et al. 2015

Chemical Engineering Journal

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“…While, Rossmann et al [91] indicated that this time scale model is not applicable for systems forming crystalline structures. The saturation solubility of the solute in mixtures of solvents and antisolvents was proposed as the indirect classification criterion to distinguish amorphous precipitating or crystallizing.…”

Section: Fluid Dynamicsmentioning

confidence: 99%

Tailoring Particle Microstructures via Supercritical CO<sub>2</sub> Processes for Particular Drug Delivery

Liu¹,

Jiang

Wang³

2015

CPD

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Strategies for a particular drug delivery are always of great interest for the pharmaceutical industry, and efficient methods of preparing products with controlled particle microstructures are fundamental for the development and application of drug delivery. Supercritical fluid particle design (SCF PD) processes, as a green and effective alternative to traditional methods, have been effectively employed to produce particles with designated microstructures.Combining with research experiences in our research group, this review aims to provide a theoretical framework of SCF PD for particular drug delivery. For any drug delivery formulations, macroscopic properties are directly influenced by the particle microstructures, "Inverse" strategies are introduced at first to obtain the needed particle microstructures for a particular drug delivery in this paper. Then, how to produce particles with designated microstructures via SCF PD processes is discussed, mainly focus on the screening and selection of operating parameters according to thermodynamics and fluid dynamics study. Recent examples of SCF micronization and co-precipitation/ encapsulation processes are also summarized with an emphasis on how to tailor the particle microstructures by controlling the operating parameters.Finally, challenges and issues needed further study are briefly suggested for SCD PD.

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“…Titanium dioxide (TiO2) was chosen as nanoparticle model material, meanwhile the selected organic solvent was ethanol (EtOH) due to its high solubility in SCF-CO2 and it is one of the most used in anti-solvent processes [16,17]. The coating agent used in all the experiments was Pluronic-127 (F-127), a hydrophylic block copolymer with applications in drug delivery systems [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Titanium dioxide nanoparticle coating in fluidized bed via supercritical anti-solvent process (SAS)

Martín

Romero-Díez

Rodríguez‐Rojo

et al. 2015

Chemical Engineering Journal

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A process to coat nanoparticle agglomerates has been developed and its critical operation parameters have been studied in this work. It consists on a fluidized bed where a supercritical anti-solvent process (SAS) takes place. Titanium dioxide (TiO2), used as model nanoparticle, has been coated with a polymer, Pluronic F-127, from an ethanolic solution. As main factors that can affect the coating process, the following process parameters were studied: the ratio between the velocity of carbon dioxide through the bed and the minimum fluidization velocity (umf), with values from 1.5 to 2.5 times the umf; the density of carbon dioxide, varying from 640 kg/m 3 to 735 kg/m 3 approximately; the flow rate of solution, within an interval between 0.5-2 mL/min; the concentration of the solution, from 0.030 mg/mL to 0.090 mg/mL and the mass ratio polymer-particle, 0.45-1.8 g/g. The process parameters were selected taking into account the values that increased the yield, defined as gram of coating material per gram of introduced polymer amount, and maintained a unimodal particle size distribution (PSD), with low increment in the mean particle size with respect to raw TiO2. All the samples were analyzed by four different methods, which showed the successful results of the experiments. The yield was analyzed gravimetrically, and the PSD was determined by laser diffraction. The presence of polymer on the surface of the nanoparticle agglomerates was verified by FT-IR spectrum and fluorescence microscopy, which also showed the quality and uniformity of the coating. Furthermore, the bulk density of the samples was measured showing a lineal variation with the mass ratio polymer-particle.3

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Solute solubility as criterion for the appearance of amorphous particle precipitation or crystallization in the supercritical antisolvent (SAS) process

Cited by 55 publications

References 29 publications

Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

Tailoring Particle Microstructures via Supercritical CO<sub>2</sub> Processes for Particular Drug Delivery

Titanium dioxide nanoparticle coating in fluidized bed via supercritical anti-solvent process (SAS)

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