Solution Properties of Diblock Copolymers of Polystyrene-<i>block</i>-polybutadiene

Awan, M. A.; Dimonie, Victoria L.; Ou-Yang, D.; El‐Aasser, M. S.

doi:10.1021/la9508699

Cited by 13 publications

(14 citation statements)

References 29 publications

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“…[21][22][23][24][25][26] The combination of AF4-MALS-QELS was previously used to characterize several morphologies of polymer aggregates, in particular micelles. [27][28][29][30] The use of this technique to characterize the shapes of different polymer vesicles has been overlooked so far. Till et.…”

Section: Introductionmentioning

confidence: 99%

Shape characterization of polymersome morphologies via light scattering techniques

Abdelmohsen¹,

Rikken

Christianen

et al. 2016

Polymer

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Polymersomes, vesicles self-assembled from amphiphilic block copolymers, are well known for their robustness and for their broad applicability. Generating polymersomes of different shape is a topic of recent attention, specifically in the field of biomedical applications. To obtain information about their exact shape, tomography based on cryo-electron microscopy is usually the most preferred technique. Unfortunately, this technique is rather time consuming and expensive. Here we demonstrate an alternative analytical approach for the characterization of differently shaped polymersomes such as spheres, prolates and discs via the combination of multi-angle light scattering (MALS) and quasi-elastic light scattering (QELS). The use of these coupled techniques allowed for accurate determination of both the radius of gyration (R g ) and the hydrodynamic radius (R h ). This afforded us to determine the shape ratio ρ (R g /R h ) with which we were able to distinguish between polymersome spheres, discs and rods.

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Section: Introductionmentioning

confidence: 99%

Shape characterization of polymersome morphologies via light scattering techniques

Abdelmohsen¹,

Rikken

Christianen

et al. 2016

Polymer

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“…Of the various FFF sub‐techniques, AF4 and ThFFF were shown to be capable of successfully characterising self‐assemblies (such as micelles and polymersomes) in terms of size, molar mass (as well as their respective distributions) and morphology, which is not possible with column‐based techniques . Moreover, it was demonstrated that in some instances AF4 could reveal the presence of size distributions that were not observed using traditional bulk techniques such as DLS while ThFFF was shown to be a suitable technique for the analysis of micelles with different core compositions …”

Section: Characterisation Of Micelle Property Distributionsmentioning

confidence: 99%

Characterisation of block copolymer self‐assemblies by thermal field‐flow fractionation

Greyling

Pasch

2017

Polymer International

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The ability of block copolymers to self‐assemble into various nanostructures (such as micelles) has attracted significant attention over the years as these block copolymers provide a versatile platform that can readily be modified for a wide range of applications. As such, the solution behaviour of block copolymers has been at the forefront of the modern nanotechnology revolution. However, these novel block copolymer‐based self‐assemblies lack suitable characterisation techniques to determine size, molar mass and compositional distributions simultaneously. This mini‐review gives a short background on the current techniques used to determine important micelle properties as well as their limitations for characterising complex samples. Current column‐based fractionation techniques used for determining property distributions are addressed. As a result of the limitations of column‐based fractionations, a multidetector thermal field‐flow fractionation (ThFFF) approach is put forward as a powerful alternative for determining not only size and molar mass distributions, but also other micelle properties as a function of temperature. More importantly, ThFFF is highlighted as the only current characterisation platform capable of addressing the analytical challenges associated with compositional distributions of polymer self‐assemblies. © 2017 Society of Chemical Industry

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“…However, SEC showed analyte trapping in the column, disassembly of micelles, and adsorption on the column packing occurring during analysis. , Moreover, as SEC is not an absolute method, it requires calibration, and since it is impossible to prepare micelle calibration standards, only indicative molar masses are obtained . On the other hand, FFF subtechniques such as flow field-flow fractionation (FlFFF), asymmetric flow field-flow fractionation (AF4), and thermal field-flow fractionation (ThFFF) have been shown to be suitable techniques for the characterization of self-assemblies such as micelles. ,, It was shown that FlFFF, AF4, and ThFFF can determine size, PSD, morphology, molar mass, and MMD of micelles and other self-assemblies, such as polymersomes, and that they can reveal size distributions not observed by traditional techniques such as DLS. ,− However, FlFFF, AF4, and ThFFF can all separate analytes according to size, but only ThFFF can separate analytes according to size and chemical composition. − …”

Section: Introductionmentioning

confidence: 99%

“…4 On the other hand, FFF subtechniques such as flow field-flow fractionation (FlFFF), asymmetric flow fieldflow fractionation (AF4), and thermal field-flow fractionation (ThFFF) have been shown to be suitable techniques for the characterization of self-assemblies such as micelles. 7,12,13 It was shown that FlFFF, AF4, and ThFFF can determine size, PSD, morphology, molar mass, and MMD of micelles and other selfassemblies, such as polymersomes, and that they can reveal size distributions not observed by traditional techniques such as DLS. 7,12−14 analytes according to size, but only ThFFF can separate analytes according to size and chemical composition.…”

Section: ■ Introductionmentioning

confidence: 99%

Multidetector Thermal Field-Flow Fractionation: A Unique Tool for Monitoring the Structure and Dynamics of Block Copolymer Micelles

Greyling

Pasch

2016

Macromolecules

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Block copolymer micelles have attracted much attention as a versatile platform that can readily be adapted to a wide range of applications including drug delivery and the production of nanoscale patterns. However, current analytical techniques are not suitable to provide comprehensive information regarding size, molar mass, chemical composition, and micelle stability in different environments. It is shown by the analysis of polybutadiene−polystyrene micelles with various corona compositions that, in contrast to current techniques, multidetector thermal field-flow fractionation (ThFFF) is capable of separating micelles according to corona composition and providing comprehensive information on important micelle characteristics such as size, molar mass, chemical composition, and their respective distributions from a single analysis. Moreover, it is shown that ThFFF is a suitable technique to monitor the dynamics of mixed micelle formation in terms of size, molar mass, and chemical composition.

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Solution Properties of Diblock Copolymers of Polystyrene-block-polybutadiene

Cited by 13 publications

References 29 publications

Shape characterization of polymersome morphologies via light scattering techniques

Shape characterization of polymersome morphologies via light scattering techniques

Characterisation of block copolymer self‐assemblies by thermal field‐flow fractionation

Multidetector Thermal Field-Flow Fractionation: A Unique Tool for Monitoring the Structure and Dynamics of Block Copolymer Micelles

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