Solution Properties of Poly(N-isopropylacrylamide)

Thermally Responsive Amphiphilic Conetworks and Gels Based on Poly(N-isopropylacrylamide) and Polyisobutylene

“…2,3 Above a certain temperature, the hydrophilic PNiPAAm changes its philicity, rapidly becomes hydrophobic, 4 and the polymer and the gel precipitates and collapses, respectively. 2,3 This temperature, the so called lower critical solubility temperature (LCST), is around 32 ˚C 1 for this polymer, which is close to the temperature of the human body. The combination of this thermoresponsive behavior with the biocompatibility of PNiPAAm makes it interesting for a large variety of applications, for example in the fields if biology, medicine or sensors.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12] This polymer in aqueous solution, as well as its gel in swollen state, is sensitive to the temperature of the environment. 2,3 Above a certain temperature, the hydrophilic PNiPAAm changes its philicity, rapidly becomes hydrophobic, 4 and the polymer and the gel precipitates and collapses, respectively. 2,3 This temperature, the so called lower critical solubility temperature (LCST), is around 32 ˚C 1 for this polymer, which is close to the temperature of the human body.…”

Synthesis and characterization of PIL/pNIPAAm hybrid hydrogels

“…Whereas pNIPAAm is the best investigated thermoresponsive hydrogel with an LCST transition at 32°C [5,6], the N-vinylimidazolium based IL [ViPrIm] + [Br] − is a less researched attractive co-monomer in biomedical applications.…”

Infrared light induced patterning of proteins on ppNIPAM thermoresponsive thin films: a “protein laser printer”

“…This paper presents an alternative method for protein patterning using laser-induced adsorption of proteins on a "smart polymer" thin film, leading to fast adsorption times and high resolution. Prior work [7] has established that poly-N-isopropylacrylamide (pNIPAM) exhibits a distinct reversible phase transition at its lower critical solution temperature (LCST) of 31°C: below, it is hydrophilic and protein-repelling (non-fouling); above, it is hydrophobic and protein-adsorbing (bio-fouling). pNIPAM thermoresponsive thin films can be synthesized by vapor phase plasma deposition ("ppNIPAM") [8].…”