Simulation is a tradition of operating a process or system in the real world. The act of simulating something first requires the development of a model; this model represents the main characteristics of the selected behaviors, processes, and functions. The model represents the system itself, while the simulation represents the operation of the system over time. In this paper, the optimal solutions of fractional human T-cell lymphotropic virus model infection of CD4+ T-cells will selected by using an efficient technique, called the LHAM, which is a series solution method based on the HAM and Laplace transform in obtaining the solutions for a wide class of problem. The Pade approximation technique to enlarge region of convergence for the solutions. Results obtained using the shame presented here are in good agreement with the numerical results obtained before. Our work confirms the efficiency of LHAM as a tool for solving linear and nonlinear fractional differential equations. The numerical method proposed in this thesis can be utilized to solve other problems in field of nonlinear fractional differential equations.