Solvent‐Cast Polymeric Films from Pectin and Eudragit® NE 30D for Transdermal Drug Delivery Systems

Abstract

In this study, solvent-cast polymeric lms containing ionic liquid lidocaine/aspirin for transdermal patches were developed. Solvent-cast polymeric lms were prepared from two polymers, pectin and Eudragit ® NE 30D, by drying the polymeric solution in a hot air oven at 70 ± 3°C for 10 hrs. Glycerin was used as a plasticizer. Lidocaine and aspirin were prepared in ionic liquid form and loaded into the patches. The physicomechanical properties of the lms were characterized by texture analysis, differential scanning calorimetry, thermogravimetric analysis, and X-ray diffraction. A scanning electron microscope was used to photograph the surfaces of solvent-cast polymeric lms. Eudragit ® NE 30D signi cantly decreased the toughness and rigidity of the lms. The transdermal patches were in the amorphous state, and their thermal properties were not changed from blank polymeric lms. The surfaces of transdermal patches were rougher than blank polymeric lms and revealed the distribution of the drug. Eudragit ® NE 30D signi cantly decreased the trends of entrapment e ciency and in vitro release of lidocaine and aspirin drugs. The kinetic release observed in vitro tted to Higuchi's model rather than zero and rst order models, indicating that a diffusion mechanism governed the release of the drug from the patch. Thus, the solvent-cast polymeric lms from two polymers, pectin and Eudragit ® NE 30D, are suitable for transdermal patches loaded with ionic liquid lidocaine/aspirin.

A Sustainable Solution to Skin Diseases: Ecofriendly Transdermal Patches

“…Despite minimized environmental impact, they may still show inferior performance regarding end-use applications compared to synthetic counterparts [ 25 ]. A wide range of natural polymers such as chitosan [ 26 ], cellulose [ 27 ], pectin [ 28 ], alginate [ 29 , 30 ], gelatin [ 31 ], and starch [ 32 ] have been utilized to manufacture ecofriendly patches to treat skin diseases ( Table 2 ). The features such as swelling, biodegradability, stretchability, drug loading capacity, and drug release rate need to be taken into account for manufacturing patches for a specific skin disease ( Figure 2 ).…”

Development of Procaine Loaded Transdermal Patches Based on Biopolymer Pectin, Castor Oil, and Polyethylene Glycol for Controllable Drug Release Studies and Their Characterizations

“…Drug molecule was released successfully and anti‐inflammatory effects were kept [16] . Although pectin has superior features it has not been used in the TD patch design, frequently [17–19] . Pectin is a biodegradable, natural, biocompatible, gas and water‐permeable, and eco‐friendly material and has gelling properties.…”

“…[16] Although pectin has superior features it has not been used in the TD patch design, frequently. [17][18][19] Pectin is a biodegradable, natural, biocompatible, gas and water-permeable, and eco-friendly material and has gelling properties. Its gelling property allows it to be chosen for controlled drug delivery studies due to its porosity structure in the gel.…”

Optimization and Preliminary Physicochemical Characterization of Pectin Extraction from Watermelon Rind (Citrullus lanatus) with Citric Acid

“…Some of the pharmaceutical applications of pectin are to diminish lipid digestion [ 12 ]⁠, to improve lipid hepatic accumulation [ 13 ]⁠, glucose tolerance for antidiabetic effects [ 14 ]⁠, and its anti-inflammatory activity in high methoxyl pectins [ 15 ]⁠. Recently, the low hydrophilic of pectin has taken advantage to improve carrier properties and diffusion control of nicotine in transdermal patches [ 16 , 17 ]⁠ and drug delivery such as theophylline tablets [ 18 ]⁠ and lidocaine and aspirin in ionic liquid [ 19 ]⁠.…”