Solvent extraction and purification of rosmarinic acid from supercritical fluid extraction fractionation waste: Economic evaluation and scale-up

Zibetti, André Wüst; Aydi, Abdelkarim; Livia, Mayra Arauco; Bolzan, Ariovaldo; Barth, Danielle

doi:10.1016/j.supflu.2013.09.005

Cited by 41 publications

(29 citation statements)

References 49 publications

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“…This may be because in the herein work the proportion of the hydro-alcoholic mixtures was included as variable. This fact is corroborated by the results found by other authors dealing with the extraction of RA: a) Kim et al [10], reported better RA extraction yields with hydro-alcoholic mixtures (methanol-based); b) Bellumori et al [20], found that MAE and UAE using water:ethanol mixtures or water:acetone mixtures considerably increase the archived yields (using R. officinalis L.) comparatively with more traditional used solid-liquid extraction processes; c) Bernatoniene et al [41], described that UAE with 90% ethanol would increase the RA extraction yield from rosemary leaves; and d) even when other techniques, such as supercritical CO 2 extraction, were used to extract RA, hydro-alcoholic mixtures with 70% ethanol were reported to produce the better results [42].…”

Section: Comparison With Other Studies Involving the Extraction Of Romentioning

confidence: 99%

Extraction of rosmarinic acid from Melissa officinalis L. by heat-, microwave- and ultrasound-assisted extraction techniques: A comparative study through response surface analysis

Caleja

Barros

Prieto

et al. 2017

Separation and Purification Technology

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a b s t r a c tThe goal of this study was to compare the extraction of rosmarinic acid from Melissa officinalis L. using three techniques (heat--, microwave-and ultrasound-assisted extraction). In order to obtain the conditions that maximize the rosmarinic acid extraction, a response surface methodology was applied using the circumscribed central composite design of three variables with five levels. The relevant independent variables used for the process optimization were time, temperature and ethanol-water proportion for heat-assisted-and microwave-extration, whereas for the ultrasound method the ultrasonic power was variable. The responses used as criteria were the amount of rosmarinic acid was determined by HPLCDADand the extraction yield of the obtained residue. Ultrasound extraction proved to be the most effective method, capable of yielding 86.3 ± 4.1 mg rosmarinic acid/g plant per dry weight (dw) at the optimal extraction conditions (33.0 ± 3.2 min, 371.7 ± 19.3 W and 39.9 ± 1.4% of ethanol). According to the content of rosmarinic acid, microwave-and heat-assisted extractions techniques were less effective, producing 49.4 ± 2.3 (at 26.5 ± 2.1 min, 108.6 ± 10.2°C and 25.5 ± 0.9% of ethanol) and 59.4 ± 2.2 (at 106.2 ± 5.1 min, 88.0 ± 2.9°C and 34.5 ± 1.6% of ethanol), respectively. Additionally, the solid/liquid ratio effect at the optimal values in a dose-response format was studied in view of its plausible transference at industrial level, showing a decreasing non-linear pattern from 5 to 120 g/L. In brief, the obtained results highlight the potential applications of using the leaves from M. officinalis as a source of rosmarinic acid.

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Section: Comparison With Other Studies Involving the Extraction Of Romentioning

confidence: 99%

Extraction of rosmarinic acid from Melissa officinalis L. by heat-, microwave- and ultrasound-assisted extraction techniques: A comparative study through response surface analysis

Caleja

Barros

Prieto

et al. 2017

Separation and Purification Technology

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show abstract

“…These models exploit the kinetic behavior of the dynamic extraction period, and offer parameters such as mass transfer coefficient, diffusion coefficient and diffusivity in the solid phase (Sovová, 2012;Özkal and Yener, 2016). In addition, the modeling of the kinetic curves of extraction makes it possible to suggest scale-up methodology to predict the behavior of the extraction process on an industrial scale (Prado et al, 2012;Wüst Zibetti et al, 2013;Taher et al, 2014).…”

Section: Identified Terpenoids Referencementioning

confidence: 99%

Phytochemical profile and biological activities of Momordica charantia L. (Cucurbitaceae): A review

Oliveira¹,

Costa²,

Bezerra³

et al. 2018

Afr. J. Biotechnol.

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This study discusses the bioactive composition, supercritical fluid extraction and biological activities of Momordica charantia L. from the last five years. Numerous compounds that have been identified in the extracts of M. charantia, including phytosterols, terpenoids, fatty acids, phenolic compounds, phenolic acids and flavonoids were also discussed. Although, several studies reported the use of organic solvents in the extraction of these compounds, this review emphasized on supercritical fluid extraction (SFE), good selectivity, varied fractions in terms of mass yields and chemical composition obtained, in addition to providing a solvent-free extract. Moreover, the biological effects of M. charantia extracts, including their antidiabetic, neuroprotective, anti-obesogenic, antimalarial, antioxidant, antiinflammatory, antimicrobial and allelopathic activities, were discussed. These biological effects of the extracts of M. charantia can directly affect human health. The findings of this review are important, as they can guide future studies related to obtaining bioactive compounds from M. charantia and its applications.

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“…The authors observed that the sequential process had a substantial effect on the extract's yield and composition. Regarding the fractionation of target compounds after the extraction, Zibetti et al [19] obtained and purified by supercritical fluid chromatography (SFC) some antioxidant compounds from plant material and plant waste of rosemary, and achieved products with different compositions. First, the supercritical fractionated rosemary extract with different composition was obtained from the leaves (higher concentration of eucalyptol-compounds with proved antimicrobial activity), and next, a potent antioxidant, rosmarinic acid, was successfully extracted from waste produced from the supercritical [43] extraction.…”

Section: Fruit and Vegetable Processingmentioning

confidence: 99%

“…Eventually the formed bubbles cannot absorb the energy any longer and will collapse: "cavitation" takes place [11,33]. When cavitation occurs close to solid surfaces, cavity collapse produces high-speed jets of liquid that impact strongly to the solid surface, and leads to pitting and erosion of the surface [19,83]. In addition, due to the cavitation process solid surfaces can be penetrated, providing easier access of the solvent into cells, enhancing mass transfer [11].…”

Section: Ultrasoundmentioning

confidence: 99%

Sub- and supercritical fluid technology applied to food waste processing

Viganó

Machado

Martínez

2015

The Journal of Supercritical Fluids

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Solvent extraction and purification of rosmarinic acid from supercritical fluid extraction fractionation waste: Economic evaluation and scale-up

Cited by 41 publications

References 49 publications

Extraction of rosmarinic acid from Melissa officinalis L. by heat-, microwave- and ultrasound-assisted extraction techniques: A comparative study through response surface analysis

Extraction of rosmarinic acid from Melissa officinalis L. by heat-, microwave- and ultrasound-assisted extraction techniques: A comparative study through response surface analysis

Phytochemical profile and biological activities of Momordica charantia L. (Cucurbitaceae): A review

Sub- and supercritical fluid technology applied to food waste processing

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