Solvent extraction of rosmarinic acid from lemon balm and concentration of extracts by nanofiltration: Effect of plant pre-treatment by supercritical carbon dioxide

Peev, G.; Penchev, P.; Peshev, D.; Angelov, George

doi:10.1016/j.cherd.2011.04.014

Cited by 43 publications

(26 citation statements)

References 16 publications

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“…33 Some studies reported that for the extraction of RA, a variety of concentrations of binary solvent mixtures such as water, methanol, and ethanol is used. 4,[42][43][44] Other solvents such as acetone, chloroform, and ethyl acetate have also been reported. [45][46][47] In preparing extracts of RA-rich plants, it is advisable to use either an acidified ethanol or methanol-water mixtures, because such solvent systems denature the cell membrane of plants and stabilize the RA.…”

Section: Extraction Of Ra From Lamiaceae Plantsmentioning

confidence: 99%

Recent Advances in the Analysis of Rosmarinic Acid From Herbs in the Lamiaceae Family

Sik

Kapcsándi

Székelyhidi

et al. 2019

Natural Product Communications

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Rosmarinic acid (RA) is a phenolic acid found in a variety of plants, especially those in the Lamiaceae family. A number of biological effects are attributed to the compound; so, in recent years, RA has been the focus of many studies. The aim of this review is to provide information on the latest developments on flow chromatography analysis of RA. A reverse-phase high-performance liquid chromatography (HPLC) method with gradient elution and either diode array or mass spectrometric detection is usually used to measure the compound. Factors affecting the performance of HPLC analysis of RA such as sample preparation, column, mobile phase, and detection methods are discussed in detail in this review.

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Section: Extraction Of Ra From Lamiaceae Plantsmentioning

confidence: 99%

Recent Advances in the Analysis of Rosmarinic Acid From Herbs in the Lamiaceae Family

Sik

Kapcsándi

Székelyhidi

et al. 2019

Natural Product Communications

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show abstract

“…The lipids used range from triglycerides, mono, di and triglycerides mixtures to waxes, hard fats and other types of lipids, having a special feature of melting point above room and body temperature. 15 The technological handling of such type of compounds is sometimes limitative since they are very reactive, and their incorporation in a food formulation may bring some difficulties if these compounds are not protected. 4, 5 The favorable physical and chemical properties stability, good tolerability and biodegradability and the possibility of large-scale production, have demonstrated that SLN can be good vehicles to functional ingredients in the food industry.…”

Section: Introductionmentioning

confidence: 99%

Characterization of solid lipid nanoparticles produced with carnauba wax for rosmarinic acid oral delivery

et al. 2015

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In the last decade, research studies have increased on the development of delivery systems for polyphenols, for protection, improvement of stability and increase of their bioavailability. Rosmarinic acid is a polyphenol with described bioactivities, such as antioxidant, anti-mutagenic, anti-bacterial and anti-viral capabilities. Thus, the aim of this research work was to produce stable solid lipid nanoparticles (SLN) using carnauba wax as lipidic matrix, for delivery of rosmarinic acid, to be further incorporated into food matrices.Hence, different concentrations of wax (0.5, 1 and 1.5%, w/v) and percentages of surfactant (1, 2 and 3%, v/v) were tested. Physical properties, surface morphology and association efficiencies were studied at time of production and after 28 day at refrigerated storage. Thermal properties and the nature of the chemical interactions between the lipids waxes and rosmarinic acid were also evaluated. The particles showed range size between 35-927 nm and zeta potentials of ca. À38 to 40, showing high stability, with no risk of aggregation due to electric repulsion of SLN. High association efficiencies % (ca. 99%) were obtained. FTIR analyses proved the association of rosmarinic acid and lipidic matrix. The low lipid and high surfactant concentrations leads to small SLN. The surfactant, polysorbate 80 decreases the interfacial tension in the SLN surfaces, preventing aggregation, leading to the development of small particles. These properties were maintained throughout the 28 day of refrigerated storage, and no rosmarinic acid was released by the particles during refrigeration, indicating good compatibility between rosmarinic acid and the waxy core of SLN. The optimum range values to obtain the desirable features for incorporation in a functional food suggest formulations containing 1.0 and 1.5% (w/v) of lipid and 2% (v/v) of surfactant.

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“…Nowadays, the biological potential of various plant waste materials is the focus of numerous studies. This trend includes not only the examination of aromatic plants [43,60,61,62], but also different fruits and plant products such as wine, olives, beetroot, tomato, garlic, and pomegranate [63,64,65,66]. These investigations also include their antimicrobial activity, considering the fact that waste material extracts represent the valuable source of different phenolic compounds.…”

Section: Compounds Percentage (%) Referencesmentioning

confidence: 99%

Natural Products as Antibacterial Agents — Antibacterial Potential and Safety of Post-distillation and Waste Material from Thymus vulgaris L., Lamiaceae

Gavarić¹,

Kovač²,

Kretschmer³

et al. 2015

Concepts, Compounds and the Alternatives of Antibacterials

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Medicinal plants have a long tradition of use in folk and conventional medicine. In recent years numerous studies confirm various bioactivities of natural products, among them antibacterial activity. Natural antibacterial agents such are essential oils and isolated compounds now represent a notable source for pharmaceutical and food industry and are widely used in cosmetology. They meet standards of 'green consumerism' together with excellent antibacterial activity. Aromatic plants such is Thymus vulgaris L. are the major sources of essential oils. Thyme essential oil, as well

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Solvent extraction of rosmarinic acid from lemon balm and concentration of extracts by nanofiltration: Effect of plant pre-treatment by supercritical carbon dioxide

Cited by 43 publications

References 16 publications

Recent Advances in the Analysis of Rosmarinic Acid From Herbs in the Lamiaceae Family

Recent Advances in the Analysis of Rosmarinic Acid From Herbs in the Lamiaceae Family

Characterization of solid lipid nanoparticles produced with carnauba wax for rosmarinic acid oral delivery

Natural Products as Antibacterial Agents — Antibacterial Potential and Safety of Post-distillation and Waste Material from Thymus vulgaris L., Lamiaceae

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