Solvent-Free Aqueous Dispersions of Block Copolyesters for Electrospinning of Biodegradable Nonwoven Mats for Biomedical Applications

Bubel, Kathrin; Grunenberg, Daniel; Vasilyev, Gleb; Zussman, Eyal; Agarwal, Seema; Greiner, Andreas

doi:10.1002/mame.201400116

Cited by 8 publications

(6 citation statements)

References 38 publications

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“…Both bacteria have in common that they do not survive organic solvents, which excludes standard processing of hydrophobic polymers like film casting, solution spinning, and electrospinning. Electrospinning, which is the state‐of‐the‐art technique for nano/mesofiber–based nonwovens, proved particularly useful for the immobilization of functional bacteria due to the high potential for mass transport. However, hydrophobic water‐resistant polymers are required for numerous applications, for example, in textiles, agriculture, microbial fuel cells, or water purification.…”

Section: Introductionmentioning

confidence: 99%

High‐Temperature Spray‐Dried Polymer/Bacteria Microparticles for Electrospinning of Composite Nonwovens

Reich

Kaiser

Mafi

et al. 2019

Macromolecular Bioscience

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Spray Dried BiocompositesLiving Micrococcus luteus (M. luteus) and Escherichia coli (E. coli) are encapsulated in poly(vinyl alcohol), poly(vinylpyrrolidone), hydroxypropyl cellulose, and gelatin by high-temperature spray drying. The challenge is the survival of the bacteria during the standard spray-drying process at temperatures of 150 °C (M. luteus) and 120 °C (E. coli). Raman imaging and transmission electron microscopy indicate encapsulated bacteria in hollow composite microparticles. The versatility of the spray-dried polymer bacteria microparticles is successfully proved by standard polymer solution-processing techniques such as electrospinning, even with harmful solvents, to water-insoluble polyacrylonitrile, polystyrene, poly(methyl methacrylate), and poly(vinyl butyrate) nanofiber nonwovens, which opens numerous new opportunities for novel applications.

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Section: Introductionmentioning

confidence: 99%

High‐Temperature Spray‐Dried Polymer/Bacteria Microparticles for Electrospinning of Composite Nonwovens

Reich

Kaiser

Mafi

et al. 2019

Macromolecular Bioscience

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“…Therefore, our broad aim is to replace organic solvent based electrospinning of water insoluble polymers with water based formulations. Water based electrospinning is a must for many applications such as applications in the biomedical field, agricultural applications, and wound healing, and it is highly desirable for others in which the use of large amounts of toxic and flammable solvents should be avoided. − In the past, we have shown use of primary and secondary dispersions/suspensions of hydrophobic polyesters and amphiphilic polymers as green routes of making corresponding nanofibers. − They are generated either in situ by emulsion/suspension polymerization (primary dispersion) or by dispersing a ready-made water insoluble polymer in water. The method is applicable to many different polymers but cannot be utilized for PI.…”

Section: Introductionmentioning

confidence: 99%

Polyimide Nanofibers by “Green” Electrospinning via Aqueous Solution for Filtration Applications

Jiang

Hou

Agarwal

et al. 2016

ACS Sustainable Chem. Eng.

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137

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The use of large amounts of environmentally unfriendly, toxic, and flammable organic solvents in electrospinning of polymers puts demand on the development of new methods and formulations for making water stable hydrophobic nanofibers from water-soluble precursor solution. Electrospun polyimide (PI) nanofibers are of particular interest for a variety of applications due to their extraordinary thermal and chemical stability. However, the intermediate precursor of polyimide, the polyamic acid (PAA) has to be electrospun from harmful solvents like dimethylformamide (DMF) which is a serious obstacle for technical applications of electrospun PI. This work highlights the formation of PI nanofibers by “green” electrospinning of ammonium salts of PAA from water. The high temperature used for imidization in the second step also removed ammonia and the template polymer by sintering giving PI nanofibers with diameter 295 ± 58 nm. The thus obtained PI nanofibers by “green” electrospinning were defined as “green” PI nanofibers. Aerosol filtration of “green” PI nanofibers showed a performance that was very similar to PI nanofibers obtained by electrospinning of PAA from DMF. Additionally, it has been shown that the “green” PI nanofibers were suitable for the filtration of hot oil as well.

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“…The dispersions were prepared according to a previously published procedure [ 26 ]. In short: solvent displacement (2.5% w/w PCL- b -MPEG; 2–2.5% w/w artemisione) took place.…”

Section: Methodsmentioning

confidence: 99%

Controlled release of artemisone for the treatment of experimental cerebral malaria

et al. 2017

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BackgroundCerebral malaria (CM) is a leading cause of malarial mortality resulting from infection by Plasmodium falciparum. Treatment commonly involves adjunctive care and injections or transfusion of artemisinins. All artemisinins that are in current use are metabolized to dihydroxyartemisinin (DHA), to which there is already some parasite resistance. We used artemisone, a derivative that does not convert to DHA, has improved pharmacokinetics and anti-plasmodial activity and is also anti-inflammatory (an advantage given the immunopathological nature of CM).MethodsWe examined controlled artemisone release from biodegradable polymers in a mouse CM model. This would improve treatment by exposing the parasites for a longer period to a non-toxic drug concentration, high enough to eliminate the pathogen and prevent CM. The preparations were inserted into mice as prophylaxis, early or late treatment in the disease course.ResultsThe most efficient formulation was a rigid polymer, containing 80 mg/kg artemisone, which cured all of the mice when used as early treatment and 60% of the mice when used as a very late treatment (at which stage all control mice would die of CM within 24 h). In those mice that were not completely cured, relapse followed a latent period of more than seven days. Prophylactic treatment four days prior to the infection prevented CM. We also measured the amount of artemisone released from the rigid polymers using a bioassay with cultured P. falciparum. Significant amounts of artemisone were released throughout at least ten days, in line with the in vivo prophylactic results.ConclusionsOverall, we demonstrate, as a proof-of-concept, a controlled-sustained release system of artemisone for treatment of CM. Mice were cured or if treated at a very late stage of the disease, depicted a delay of a week before death. This delay would enable a considerable time window for exact diagnosis and appropriate additional treatment. Identical methods could be used for other parasites that are sensitive to artemisinins (e.g. Toxoplasma gondii and Neospora caninum).

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Solvent-Free Aqueous Dispersions of Block Copolyesters for Electrospinning of Biodegradable Nonwoven Mats for Biomedical Applications

Cited by 8 publications

References 38 publications

High‐Temperature Spray‐Dried Polymer/Bacteria Microparticles for Electrospinning of Composite Nonwovens

High‐Temperature Spray‐Dried Polymer/Bacteria Microparticles for Electrospinning of Composite Nonwovens

Polyimide Nanofibers by “Green” Electrospinning via Aqueous Solution for Filtration Applications

Controlled release of artemisone for the treatment of experimental cerebral malaria

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