Solvent-free, Environmentally Benign Syntheses of Some Imines and Antioxidant Activity

Microwave‐enhanced heterocyclization: A convenient procedure for 1,5‐benzothiazepine using 2‐ethoxy ethanol solvent and its antibacterial potential

“…Solid separated was isolated by simple Buchner filtration; final purification was achieved by recrystallization from the mixture of ethanol:dioxane to give the corresponding 1,5‐benzothiazepines (3a–j) (Scheme 1). The purity of product was checked by thin‐layer chromatography [19]. The time required for completion of reaction, percent yield, and melting points are given in Table 1.…”

“…In all cases, reaction proceed easily with high yields in minimum time and with maximum purity for the desired product. The formation of 1,5‐benzothiazepines were understood to proceed through the Michael‐type addition of sulfur in o ‐aminothiophenol to activated double bond of chalcones followed by intramolecular cyclization [19, 36] with the elimination of water molecule (Scheme 2).…”

“…1,5‐Benzothiazepines are widely used as anticonvulsant [9, 10], anti‐inflammatory [11], antifungal [12], antiarrhythmic [13], antibacterial [14, 15], anti‐breast cancer [6], antihypertensive [16], anticancer [17] hypnotic, anti‐HIV, as well as antitubercular agents [18]. Moreover, 1,5‐benzothiazepines have been combined with other well‐known pharmaceutically active compounds such as substituted naphthalene derivatives to form a single molecule with improved pharmaceutical properties [19]. Therefore, their beneficial properties have prompted us to study these compounds.…”

The crystal structure of N-((1E,2E)-1,3-bis(4-fluorophenyl)but-2-en-1-ylidene)-4-methylbenzenesulfonamide, C23H19F2NO2S

“…Imines, on the one hand, belong to bioactive compounds with various biological activities including antidiabetic, anticancer and antimicrobial effects [4][5][6]. On the other hand, they are the important intermediates to achieve functional molecules, such as quinolones and 1,3-oxazines [7,8].…”