Solvent-free functionalization of silicone rubber and efficacy of PAAm brushes grafted from an amino-PPX layer against bacterial adhesion

Fundeanu, Irina; Klee, Doris; Schouten, A.J.; Busscher, Henk J.; Mei, Henny C. van der

doi:10.1016/j.actbio.2010.06.010

Cited by 26 publications

(19 citation statements)

References 29 publications

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“…There are many different ways in which these polymers can be attached to the surface. Also the sort of polymers used can differ from linear to branched, like star-shaped, and from homo-polymers to block-copolymers [34][35][36][37]. These polymers all have in common that they are in most cases hydrophilic.…”

Section: Protein-and Microorganism-repellent Coatingsmentioning

confidence: 99%

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

2011

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Bacterial infection from medical devices is a major problem and accounts for an increasing number of deaths as well as high medical costs. Many different strategies have been developed to decrease the incidence of medical device related infection. One way to prevent infection is by modifying the surface of the devices in such a way that no bacterial adhesion can occur. This requires modification of the complete surface with, mostly, hydrophilic polymeric surface coatings. These materials are designed to be non-fouling, meaning that protein adsorption and subsequent microbial adhesion are minimized. Incorporation of antimicrobial agents in the bulk material or as a surface coating has been considered a viable alternative for systemic application of antibiotics. However, the manifestation of more and more multi-drug resistant bacterial strains restrains the use of antibiotics in a preventive strategy. The application of silver nanoparticles on the surface of medical devices has been used to prevent bacterial adhesion and subsequent biofilm formation. The nanoparticles are either deposited directly on the device surface, or applied in a polymeric surface coating. The silver is slowly released from the surface, thereby killing the bacteria present near the surface. In the last decade there has been a surplus of studies applying the concept of silver nanoparticles as an antimicrobial agent on a range of different medical devices. The main problem however is that the exact antimicrobial mechanism of silver remains unclear. Additionally, the antimicrobial efficacy of silver on OPEN ACCESSPolymers 2011, 3 341 medical devices varies to a great extent. Here we will review existing antimicrobial coating strategies and discuss the use of silver or silver nanoparticles on surfaces that are designed to prevent medical device related infections.

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Section: Protein-and Microorganism-repellent Coatingsmentioning

confidence: 99%

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

2011

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“…19,20 The long-term complications of silicone rubber are infections and capsular contracture; infections are always caused by bacterial adhesion, and capsular contracture is caused by the formation of thick fibrous capsules around the implants. [21][22][23][24] Some researchers have shown that ionimplanted silicone rubber significantly enhances cytocompatibility (e.g., carbon ion-implanted silicone rubber enhances the attachment properties of nerve cells and nerve protrusions and improves nerve regeneration). [25][26][27] Our results also show that carbon ion implantation significantly enhances biocompatibility, particularly regarding the effect of bacterial adhesion and the process of fibrosis/ fibrous capsule development.…”

Section: Discussionmentioning

confidence: 99%

Carbon Ion Implantation: A Good Method to Enhance the Biocompatibility of Silicone Rubber

Zhou

Chen

Mao

et al. 2016

Plastic &Amp; Reconstructive Surgery

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“…Oxygen/ammonia plasma and poly (ethylene-alt-maleic anhydride) (PEMA) were also added to SR to improve surface functionality to permanently improve adhesion [30]. Meanwhile, scientists have used the chemical vapor deposition method to attach some biocompatible compound to the surface of SR. Poly (o-amino-p-xylylene-co-p-xylylene) (amino-PPX) and polyacrylamide (PAAm) were introduced onto SR to help improve its surface functions [2]. For all the methods mentioned above, the manufacture procedures are complicated and contain multiple steps, conditions are relatively harsh, which makes the industrial mass manufacture almost impossible.…”

Section: Discussionmentioning

confidence: 99%

“…Silicone rubber (SR)-based materials have been used for many years, as they have excellent physiology inertia, high adsorption properties, high corrosion resistance, good chemical stability and high mechanical strength [2], [3]. It is also workable and convenient.…”

Section: Introductionmentioning

confidence: 99%

Osteopontin (OPN) Is an Important Protein to Mediate Improvements in the Biocompatibility of C Ion-Implanted Silicone Rubber

et al. 2014

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Medical device implants are drawing increasing amounts of interest from modern medical practitioners. However, this attention is not evenly spread across all such devices; most of these implantable devices can cause adverse reactions such as inflammation, fibrosis, thrombosis, and infection. In this work, the biocompatibility of silicone rubber (SR) was improved through carbon (C) ion implantation. Scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD) results confirmed that these newly generated carbon-implanted silicone rubbers (C-SRs) had large, irregular peaks and deep valleys on their surfaces. The water contact angle of the SR surface decreased significantly after C ion implantation. C ion implantation also changed the surface charge distribution, silicone oxygen rate, and chemical-element distribution of SR to favor cell attachment. The dermal fibroblasts cultured on the surface C-SR grew faster and showed more typical fibroblastic shapes. The expression levels of major adhesion proteins, including talin-1, zyxin, and vinculin, were significantly higher in dermal fibroblasts cultured on C-SR coated plates than in dermal fibroblasts cultured on SR. Those same dermal fibroblasts on C-SRs showed more pronounced adhesion and migration abilities. Osteopontin (OPN), a critical extracellular matrix (ECM) protein, was up-regulated and secreted from dermal fibroblasts cultured on C-SR. Matrix metalloproteinase-9 (MMP-9) activity was also increased. These cells were highly mobile and were able to adhere to surfaces, but these abilities were inhibited by the monoclonal antibody against OPN, or by shRNA-mediated MMP-9 knockdown. Together, these results suggest that C ion implantation significantly improves SR biocompatibility, and that OPN is important to promote cell adhesion to the C-SR surface.

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Solvent-free functionalization of silicone rubber and efficacy of PAAm brushes grafted from an amino-PPX layer against bacterial adhesion

Cited by 26 publications

References 29 publications

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

Carbon Ion Implantation: A Good Method to Enhance the Biocompatibility of Silicone Rubber

Osteopontin (OPN) Is an Important Protein to Mediate Improvements in the Biocompatibility of C Ion-Implanted Silicone Rubber

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