Solvent-free mechanochemical synthesis of bisthioglycolic acid derivatives: an efficient and versatile strategy for carbon–sulfur bond formation

A Facile, Mechanochemical, Solvent-, and Catalyst-Free Synthesis of Functionalized 4-Thiazolidinones

“…On the other hand, mechanochemical synthesis is emerging as new green method for the preparation of various heterocycles via C-O, C-N, C-S bond formation through methods like grinding, sonication [11][12][13][14][15][16][17][18] . The simple economical method offers several benefits such as less use of harmful toxic solvents, use of eco-friendly chemicals, less use of toxic and expensive metal-based catalyst, lesser release of harmful wastes and no or negligible by-product formation [19][20][21] . Since the reaction does not result in the formation of any by-product, the yield of the reaction is also remarkably higher as compared to conventional methods employed.…”