Solvent-free one-pot synthesis of polysubstituted tetrahydropyrimidines and their antioxidant and antimicrobial properties

Catalyst-free multicomponent synthesis of novel adamantyl-containing tetrahydropyrimidine carboxylates

“…Our literature survey at this stage revealed that there are some reports [18][19][20][21][22] on the synthesis of tetrahydropyrimidine derivatives containing an ester group in position 5. Khan and coworkers reported [18] the synthesis of substituted tetrahydropyrimidine and bis-tetrahydropyrimidine derivatives in good-to-excellent yields involving the reaction of dimethyl acetylenedicarboxylate, amines/diamines, and formaldehyde in the presence of (HClO 4 -SiO 2 ) as catalyst.…”

“…Kidwai et al reported [19] an environmentally benign route for the synthesis of poly-functional tetrahydropyrimidine derivatives from acetylenic ester, aliphatic/aromatic amines and formaldehyde using ionic liquid as a recyclable catalyst. It should be mentioned that the work reported by Khan et al used [20]. Also, Das et al described [21] a three-component reaction of nitroarenes, formaldehyde, and dialkylacetylenedicarboxylates for the synthesis of 1,3,4,5-tetrasubstituted 1,2,3,6-tetrahydropyrimidines using indium as catalyst in dilute aqueous HCl at room temperature.…”

“…MCRs are advantageous due to high atom economy, simple operational procedures, and convergent characters [23]. These reactions have also been employed for the construction of C-N bonds and synthesis of different nitrogen containing heterocycles [20,24].…”

Synthesis of poly-tetrahydropyrimidine antibacterial polymers and research of their basic properties

“…Pyrimidine, a basic nitrogen-containing heterocyclic organic compound, has attracted much attention due to its biological properties such as antibacterial, antiviral, tumor treatment, and anti-inflammatory properties. [11][12][13][14] Pyrimidine compounds have several interacting functional groups, which determine their strong biological activity. 15,16 There are various substituted compounds and derivatives of pyrimidine rings in nature, including nucleotides, thiamine, and tetrahydropyrimidines.…”

Catalyst‐Free Multicomponent Tandem Polymerizations of Aliphatic Amines, Activated Alkyne, and Formaldehyde toward Poly(tetrahydropyrimidine)s

“…[10,11] Compared with the extensively studied aromatic heterocycle-containing polymers with conjugated structures and optoelectronic properties, aliphatic DOI: 10.1002/macp.202200399 heterocycle-containing polymers are less explored, due to the lack of efficient synthetic approaches. Among the nitrogen-containing heterocycles, tetrahydropyrimidines and their derivatives have drawn significant attention with their antibacterial, [12] anti-inflammatory, [13] anticancer activity, [14] and antiviral activity. [15] Poly(tetrahydropyrimidine)s with diverse structures had be prepared, which maintained promising antibacterial abilities and biocompatibility when the polymers were processed into hydrogels, [16] nanofibers, [17] and wound dressing.…”