Solvent free synthesis, characterization, anticancer, antibacterial, antifungal, antioxidant and SAR studies of novel (E)-3-aryl-1-(3-alkyl-2-pyrazinyl)-2-propenone

Kitawat, Bheru Singh; Singh, Man; Kale, R.K.

doi:10.1039/c3nj00308f

Cited by 39 publications

(20 citation statements)

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“…The antioxidant activities were assessed on a basis of free radical scavenging effect of stable DPPH • with spectrophotometric titration [17,20]. The 0.01% DPPH • stock solution was prepared in ethanol/water (1:1) and for preparing a sample solution, 5 mL DPPH • solution was mixed with 5 mL BADs solutions followed by vigorous shaking and incubated in dark.…”

Section: Experimental Measurementsmentioning

confidence: 99%

“…The data calculated for antioxidation are presented as means ± SD of three determinations. The odd numbered electrons in free DPPH • give a strong absorption maximum at 517 nm due to availability of empty space in orbital for transition and impart it a purple colored appearance which turns to yellow to form a reduced DPPH-H (Figure 1) [17,20,22,23].…”

Section: Spectrophotometric Studymentioning

confidence: 99%

“…The change in UV with position of them, the absorbances have decreased in compare to the pure DPPH • . Therefore, a sample amount can lower an initial absorbance of DPPH • solution by 50% and has been chosen as an endpoint in measuring antioxidant activity [20]. Figure 2).…”

Section: Spectrophotometric Studymentioning

confidence: 99%

“…contains absorption and scavenging activities (%) of BADs at chosen temperature where the RSA was determined as a result of decrease in absorbance of DPPH •[17,20] calculated with following formula:…”

mentioning

confidence: 99%

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An Interaction Study of Chloro and Alkyl Substituted Benzylamine with DPPH● through UV Spectrophotometric and Physicochemical Methods at T = (298.15, 303.15 and 308.15) K

Ameta¹,

Singh²,

Kitawat³

2014

MSCE

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Radical scavenging activity (RSA) of chloro and methyl substituted benzylamine derivatives (BADs) has been studied using 1, 1-diphenyl-2-picrylhydrazyl free radical (DPPH•) through spectrophotometric and physicochemical techniques at T = (298.15, 303.15 and 308.15) K. New experimental data on the density, sound velocity, isentropic and apparent molal compressibility of selected BADs + DPPH • solutions as a function of temperature and concentration are reported. The results are discussed with regards to structure-activity relationship (SAR) principles of BADs. The relative deviations in RSAs varied with structural potentials of BADs which were analyzed by making a comparative study for both the spectrophotometric and physicochemical results.

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Section: Experimental Measurementsmentioning

confidence: 99%

Section: Spectrophotometric Studymentioning

confidence: 99%

Section: Spectrophotometric Studymentioning

confidence: 99%

mentioning

confidence: 99%

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An Interaction Study of Chloro and Alkyl Substituted Benzylamine with DPPH● through UV Spectrophotometric and Physicochemical Methods at T = (298.15, 303.15 and 308.15) K

Ameta¹,

Singh²,

Kitawat³

2014

MSCE

Self Cite

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“…he γ symbol indicates surface tension of the systems, thus γ ALI indicates interfacial tension of the ALI, and γ LLI the interfacial tension of the water-CCl 4 interface. Thus, γ ALI is noted as standard and γ LLI as the sample or the test sample [13]. Similarly, DPPH free radical scavenging activities by ascorbic acid or dendrimer in two immiscible solvent systems could be determined with the following equation.…”

Section: Mutual Solubilization 100mentioning

confidence: 99%

Friccohesity and Tentropy: New Models of Molecular Sciences

Singh¹

2016

Green Nanotechnology - Overview and Further Prospects

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Understanding and developing new molecules in chemical sciences have been great thrust areas of research, not only to develop new synthetic methods or reaction mechanisms of new and greener experimental conditions but also to know what are the new molecule science and what are the new models which can track their new role in chemical processes and also their applications in allied interdisciplinary sciences. The SAR structureactivity relationship and STAR structure-thermodynamics activity relationship have been the most intimate theories in understanding and finding unique applications of the new molecules. Initially, simple molecules are the focus however, proteins, hemoglobin, starch, and certain metallic complexes are also in the focus but as natural chemicals but for past few decades, a lot of focus has been on synthesizing new complex molecules to make them suitable for varieties of applications such as solar, catalysts, biosensors, and others. Hence, it has been essential for focusing on structural sciences of the chemical substances. Dendrimers have been the invention of s in the areas of biocomplexes, biomaterials which are hot thrust areas in molecular interaction engineering to focus on intramolecular potential for industrial applications. Thus, the molecule s internal structure signifies the various scientific components for playing or making their best use in materials sciences, semiconductor, spintronics, photonics, electronics, etc. Therefore, the molecule s interacting response with other molecules becomes cohesive or kinetic in nature or whether it induces structuredness or weakens the binding forces and allows more and more kinetic movement or the motion is noted or defined by friccohesity as it is expressed as frictional and cohesive forces. Thus, the friccohesity is a dual forces theory which deals with frictional and cohesive forces together and determined with Survismeter using Mansingh equation molecules [ ].

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Steric Barrier‐Steered Reaction Sites in Micellar Catalysis

Zhang

Yin

Guan

et al. 2023

Advanced Optical Materials

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In the pursuit of an advanced micellar catalysis system, the reaction sites in micelles determine its catalytic performances. However, the intrinsic polarity gradient of micelles anchors the reactants in the fixed regions, leading to an unmet challenge to steer the reaction sites to the optimal ones. To overcome this limitation, a Förster resonance energy transfer (FRET) spectroscopic ruler is established to position the true sites of reactants in micellar catalysis by using tetraphenylethylene (TPE) in the aggregation‐induced emission (AIE) micelles as the FRET donor and Nile red as the FRET acceptor. Subsequently, the customizable TPE steric barriers in the AIE micelles are apt to mediate the reactants into the polar micellar surface, the semipolar palisade layer, or the nonpolar internal layer, achieving the corresponding catalytic efficiencies. Additionally, the universality of steric barrier‐steered reaction sites in micellar catalysis is further demonstrated by the simple incorporation of small nonpolar molecules into the commercially available surfactants. To the authors’ knowledge, this is the first report on the design of steric barriers to steer the reaction sites in micellar catalysis. These findings open up attractive perspectives for the exploration of new classes of efficient micellar catalysis systems in a variety of reactions.

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Solvent free synthesis, characterization, anticancer, antibacterial, antifungal, antioxidant and SAR studies of novel (E)-3-aryl-1-(3-alkyl-2-pyrazinyl)-2-propenone

Cited by 39 publications

References 50 publications

An Interaction Study of Chloro and Alkyl Substituted Benzylamine with DPPH● through UV Spectrophotometric and Physicochemical Methods at T = (298.15, 303.15 and 308.15) K

An Interaction Study of Chloro and Alkyl Substituted Benzylamine with DPPH● through UV Spectrophotometric and Physicochemical Methods at T = (298.15, 303.15 and 308.15) K

Friccohesity and Tentropy: New Models of Molecular Sciences

Steric Barrier‐Steered Reaction Sites in Micellar Catalysis

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