Solvent‐free Synthesis of Novel and Known Octahydroquinazolinones/thiones by the Use of ZrOCl₂.8H₂O as a Highly Efficient and Reusable Catalyst

Abstract

A solvent-free reaction between urea/thiourea, dimedone and aromatic aldehydes in the presence of catalytic amounts of zirconium (IV) oxychloride octahydrate (ZrOCl 2 .8H 2 O) as a powerfull Lewis acid leads to octahydroquinazolinone/thione derivatives in good yields. This method has advantages such as avoidance of the organic solvents, production of pure products without any by-product, short reaction times and simple operation.

Microwave‐Assisted Efficient One‐Pot Multi‐Component Synthesis of Octahydroquinazolinone Derivatives Catalyzed by Cu@Ag Core‐Shell Nanoparticle

“…It can be observed that our catalyst shows higher catalytic activity with less catalyst dose and less time interval compared to other catalysts such as, thiamine hydrochloride, Nafion‐H, conc. H 2 SO 4 , amberlite IR‐120, ammonium metavanadate, La 2 O 3 , ionic liquid, CuI nanoparticles, Cu/SiO 2 , silica sulfuric acid, ZrOCl 2 .8H 2 O, and MoO 3 –ZrO 2 . These results further suggest that our Cu 3 @Ag 1 nanocatalyst is more effecient for fine chemicals synthesis such as octahydroquinazolinone.…”

Synthesis of Novel and Thermally Stable Water Insoluble Coumarin‐based Azo Dyes via a Mild and Green Procedure

“…In continuation of our programmatic interest in development of the heterocyclic synthetic methodologies, [21][22][23][24] herein, we wish to report a simple and benign procedure for the synthesis of novel coumarin-based azo dyes through the diazotization of coumarins followed by coupling with phenols in the presence of tungstate sulfuric acid (TSA) as a heterogeneous and efficient catalyst. Firstly, 7-amino coumarin 3 was synthesized via the ZrOCl 2 ×8H 2 O/SiO 2 -catalyzed Pechmann condensation of 3-amino phenol (1) with b-ketoesters 2 under solvent-free conditions (Scheme 1).…”

Silty Clay-Containing Soil Catalyzed Microwave Assisted Multicomponent Synthesis of Octahydroquinazolinone Derivatives

“…H2SO4, 10 ionic liquids, 11 ion exchange resins, 12 Trimethyl silyl chloride, 13 Nafion-H, 14 VOSO4, 15 conc. HCl, 16 Fe(NO3).9H2O, 17 silica sulfuric acid, 18 t-BuOK, 19 TiO2, 20 ammonium metavanadate, 21 Cu(OTf)2, 22 phosphotungstic acid nanoclusters, 23 BMI.InCl4, 24 SiO2-NaHSO4, 25 ZnO2 nanoparticles, 26 phytic acid, 27 lanthanum oxide, 28 Naion-Ga, 29 CuS QDs, 30 ZrOCl2.8H2O, 31 Cu/SiO2, 32 β-cyclodextrin, aqueous hydrotropic solution of Na-p-Toluene sulfonic acid under microwave irradiation (MW), 33 BF3.SiO2, 34 Aluminate Sulfonic Acid Nanoparticles, 35 Ion exchange resin Nafion 12 H4CuPW11O39, 36 polyvinyl polyvinylpolypyrrolidine supported chlorosulfonic acid, 37 and molybdenum based heterogeneous catalysts (MoO2(acac)2 on zeolite) 38 under MW irradiation. 39…”