Solvent-mediated Highly Efficient Synthesis of [1,2,4]triazolo/benzimidazoloquinazolinone Derivatives

Abstract

Objective: An efficient and catalyst-free procedure for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones has been developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean reaction media. Methods: All of the obtained products are known compounds and identified by IR, 1HNMR,13CNMR, and melting points. Results: Various products were obtained in good to excellent yields under reaction conditions. Conclusion: We have efficiently developed a practical and catalyst-free approach for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones employing TFE as a clean and reusable media.

Facile synthesis of triazolo/benzazolo[2,1-b]quinazolinone derivatives catalyzed by a new deep eutectic mixture based on glucose, pregabalin and urea

“…Also, other studies have reported the synthesis of quinazolinone derivatives using deep eutectic solvents. 37,38 Referencing these studies demonstrates that the synthesis of quinazolinone derivatives in deep eutectic solvents has been explored in the literature. This highlights the signicance of the current study and its contribution to the existing knowledge in the eld.…”