In the presence of a catalytic amount of pentafluorophenylammonium triflate (10 mol %), dimethyl phosphite reacts with imines (generated in situ from aldehydes and amines) to yield the corresponding coupling products in good yield. The organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction mixtures.

Objective: An efficient and catalyst-free procedure for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones has been developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean reaction media. Methods: All of the obtained products are known compounds and identified by IR, 1HNMR,13CNMR, and melting points. Results: Various products were obtained in good to excellent yields under reaction conditions. Conclusion: We have efficiently developed a practical and catalyst-free approach for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones employing TFE as a clean and reusable media.

A mild and green protocol was developed for three-component, one pot synthesis of 3,4-dihydropyrimidin-2(1H)-thione derivatives in a deep eutectic solvent (DES) without the use of a catalyst or any other additive.DES based on choline chloride (ChCl) and urea offered high reaction yield and was proper for a wide range of aromatic aldehydes. In addition, after 3,4-dihydropyrimidin-2(1H)-thione synthesis, DES could be easily recycled and reused five times without any obvious changes in catalytic activity. In general, the procedure offers a number of benefits, including clean reaction profile, avoiding the use of typical toxic catalysts, an easy workup procedure, short reaction times, and low prices.

Aim and Objective: An efficient and practical procedure for the synthesis of heterocyclic compounds such as quinazolines, quinoxalines and bis(indolyl)methanes was developed using 3,5-bis(trifluoromethyl) phenyl ammonium hexafluorophosphate (BFPHP) as a novel organocatalyst. Material and Method: All of the obtained products are known compounds and identified by IR, 1HNMR, 13CNMR and melting points. Results: Various products were obtained in good to excellent yields under reaction conditions. Conclusion: The BFPHP organocatalyst demonstrates a novel class of non-asymmetric organocatalysts, which has gained much attention in green chemistry.