Solvent selection guide: a guide to the integration of environmental, health and safety criteria into the selection of solvents

Curzons, Alan D.; Constable, D.C.; Cunningham, Virginia

doi:10.1007/s100980050014

Cited by 114 publications

(121 citation statements)

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“…As the definition of "green" is neither rigorous nor strict, an objective criterion of choice among the universe of industrial solvents was needed. The Solvent Selection Guide [21] offers a strong improvement to the green performance assessment of solvents and results from the long-standing experience of GlaxoSmithKline Beecham, the pharmaceutical corporation. The company has created a tool-kit for engineers and chemists to select the best solvents, with the purpose of reducing human health impacts, multiple environment impacts and process safety risks.…”

Section: Solvent Selectionmentioning

confidence: 99%

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Efficient P(3HB) extraction from Burkholderia sacchari cells using non-chlorinated solvents

Rosengart

Cesário

Almeida

et al. 2015

Biochemical Engineering Journal

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A technique for poly-3-hydroxybutyrate (P(3HB)) extraction with safer, non-chlorinated solvents, was developed, aiming to attain high recovery yields and purities. A wide range of solvents was selected from the GlaxoSmithKline guide as sustainable industrial solvents and the solubility of P(3HB) on those solvents calculated using predictive equations from literature. Anisole, * Corresponding author: Tel.: +351 21 8419137; Fax: +351 21 8419062. e-mail address: teresa.cesario@tecnico.ulisboa.pt + Current address: Politecnico di Milano, Dipartimento di Chimica Materiali e Ingegneria Chimica "Giulio Natta". Via Mancinelli, 7 -20131 Milano MI 2 cyclohexanone and phenetole were used as extraction solvents and the relevant process variables (extraction temperature, extraction time and mass of cells/solvent volume ratio) were optimized.Polymer recovery yields of 97% and 93% were obtained with anisole and cyclohexanone, respectively, at 120-130°C using a cell/solvent ratio of 1.5% (w/v). Maximum polymer purities using these experimental conditions were 98% for both solvents. Recovery yields and polymer purity attained with chloroform (reference solvent) were 97 and 98%, respectively. Higher cell/solvent ratios of 6.0 % (w/v) showed slightly lower recovery yields and purities The average molecular weight and the thermal properties of the polymers extracted with the alternative solvents were comparable to those of the polymers obtained by chloroform extraction, showing that the applied conditions did not significantly alter the properties of the extracted P(3HB).

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Section: Solvent Selectionmentioning

confidence: 99%

“…The first one is based on the GSK Solvent Selection Guide [21][22][23] that helps in the adoption of an objective definition of 'green solvent'. The second one is the set of predictive equations developed for the solubility of P(3HB) in different organic solvents [24][25].…”

Section: Introductionmentioning

confidence: 99%

Efficient P(3HB) extraction from Burkholderia sacchari cells using non-chlorinated solvents

Rosengart

Cesário

Almeida

et al. 2015

Biochemical Engineering Journal

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“…In terms of toxicity water can be considered as non-toxic, whereas EtOH and IPA can be classified as slightly toxic [19]. Only EG is considered as moderately toxic; nevertheless, this solvent is considered as a good choice [20] from a holistic perspective. Another important aspect is that toxicity will depend on traces left in final product.…”

Section: Solvent Selectionmentioning

confidence: 99%

Development of a Sustainable Process for the Solid-Liquid Extraction of Antioxidants from Oat

et al. 2014

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Abstract:This research paper studies the development of a sustainable process for the extraction of antioxidants from oat. Experimentation covered two factorials to evaluate significance among temperature, time, particle size and solvent. Total polyphenolic content (TPC) and oxygen radical absorbance capacity (ORAC) were the response variables. ANOVA was applied to find significance among variables and predict optimum conditions though a regression model. Extractions at different solid/solvent ratios were developed to study solvents' solubility. Process simulation in Aspen Process Developer was carried out to evaluate energy cost, raw material cost, campaign time, and process mass intensity. Solvent and particle size showed significance as main effects, whereas temperature and time presented significance as interactions. From an industrial and sustainable perspective, ethanol (EtOH) in a 1/20 (w/v) ratio was the best choice since it presented the lowest cost for energy and raw material. It also showed the lowest process mass intensity (PMI), short campaign time, highest g extract/g oat, and a considerable antioxidant capacity.

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“…Researchers at GlaxoSmithKline (GSK) have developed a solvent selection guide 23,24 which provided information on 47 commonly used solvents. The guide provides the individual the opportunity to aid in solvent selection during the early stages of process development by considering aspects different than cost.…”

Section: Motivationmentioning

confidence: 99%

“…Those included: incineration, recycle, biotreatment, volatile organic carbon, environmental impact in water, environmental impact in air, health hazard, exposure potential, and safety hazard. 23 Important properties were evaluated for each of those categories and, overall, a solvent was given a score of 1 to 10 for each category, with the higher the score, the more favorably it should viewed for that category. A simplification was made to group the nine categories into four: environmental waste (incineration, recycle, biotreatment, volatile organic carbon), environmental impact (environmental impact in water, environmental impact in air), health (health hazard and exposure potential) and safety hazard.…”

Section: Motivationmentioning

confidence: 99%

Signature molecular descriptor : advanced applications.

Visco¹

2010

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In this work we report on the development of the Signature Molecular Descriptor (or Signature) for use in the solution of inverse design problems as well as in highthroughput screening applications. The ultimate goal of using Signature is to identify novel and non-intuitive chemical structures with optimal predicted properties for a given application. We demonstrate this in three studies: green solvent design, glucocorticoid receptor ligand design and the design of inhibitors for Factor XIa.

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Solvent selection guide: a guide to the integration of environmental, health and safety criteria into the selection of solvents

Cited by 114 publications

References 0 publications

Efficient P(3HB) extraction from Burkholderia sacchari cells using non-chlorinated solvents

Efficient P(3HB) extraction from Burkholderia sacchari cells using non-chlorinated solvents

Development of a Sustainable Process for the Solid-Liquid Extraction of Antioxidants from Oat

Signature molecular descriptor : advanced applications.

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