“…Fractional binary optimizations arise naturally in many contexts that involve optimization of efficiency measures (e.g., maximizing the ratio of return/investment or profit/time and minimizing the ratio of cost/time, see [10,27,32,34]), averages, probabilities and percentages, among others. Fractional optimization models can be found in diverse application areas including problems in data mining (such as feature selection [17,26] and biclustering [12,37]), scheduling [31], retail assortment [13,25,35], set covering [2,3], facility location [36], stochastic service systems [15], finding alternative solutions to binary linear programs [38], clinical trials [7], and so on. For an overview of applications and solution methods for FPs we refer to a recent survey in [10].…”