Somatic hypermutation of immunoglobulin heavy chain variable region genes in thymic marginal zone B‐cell lymphoma of MALT type of a patient with Sjögren's syndrome

Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features

“…[12][13][14][15][16][17][18][19][20][21][22][23] It is noteworthy that at least 17 (77%) of these patients are Asians. The apparent rarity of this lymphoma type in Caucasians suggests that there may be racial and/or environmental factors influencing its development.…”

“…Nine of these cases have previously been reported. 12,13,[15][16][17][21][22][23] All specimens were obtained at initial presentation and were reviewed by two independent pathologists (HI and SN). All tissue samples were fixed in 10% buffered formalin and embedded in paraffin.…”

“…2,3,10,11 Primary low-grade B-cell MALT lymphoma is very rare in the thymus, with only 16 cases having been reported in the literature to date. [12][13][14][15][16][17][18][19][20][21][22][23] Because the largest series has included only three cases, 20 and follow-up information is limited, the clinicopathological and behavioral features of this lymphoma type have not been clearly delineated.…”

Primary Extranodal Marginal Zone B-cell Lymphoma of Mucosa-Associated Lymphoid Tissue-type in the Thymus of a Patient with Sjögren's Syndrome and Rheumatoid Arthritis

“…Primary MZBLs of MALT-type have been described in a variety of sites, including gastrointestinal tract (1), thyroid gland (4) , lung (5), salivary gland (6), and ocular adnexa (7) associated with clinical setting of autoimmune diseases or chronic inflammation, usually Sjogren' s syndrome, Hashimoto' s thyroiditis, and Helicobacter pylori infection. Thymic MZBL of MALT-type is an extremely rare disease with only 22 cases having been reported in the literature to date and the largest series has included 15 cases (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). In this paper, I report a case of low-grade MZBL of MALT-type in the thymus of a patient with Sjogren' s syndrome and rheumatoid arthritis.…”

Primary hepatic mucosa-associated lymphoid tissue lymphoma and hemangioma with chronic hepatitis B virus infection as an underlying condition

“…The concept of MALT lymphoma in the gastrointestinal tract was first proposed by Isaacson and Wright in 1983 (3), and subsequent studies indicated that MALT lymphoma could involve many other sites, such as the thyroid glands, lungs, thymus, salivary glands, and liver, that are devoid of normal lymphoid tissue (4)(5)(6)(7)(8). MALT lymphomas account for approximately 7% to 8% of all non-Hodgkin lymphomas (9).…”