Somatolactin stimulates in vitro gonadal steroidogenesis in coho salmon, Oncorhynchus kisutch

Planas, Josep V.; Swanson, Penny; Rand‐Weaver, Mariann; Dickhoff, Walton W.

doi:10.1016/0016-6480(92)90142-7

Cited by 114 publications

(63 citation statements)

References 12 publications

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“…Somatolactin was first found in the flouder (Paralichthys olivaceus) [5]. Since then, it has been reported in a lot of fish species and was suggested to be involved in a lot of physiology processes such as gonadal steroid biosynthesis [34], gonadal maturation [35], stress response [36], Ca 2? regulation [37], energy mobilization [38], smoltification [39], and acidbase regulation [40].…”

Section: Discussionmentioning

confidence: 99%

EST dataset of pituitary and identification of somatolactin and novel genes in Chinese sturgeon, Acipenser sinensis

Cao

Leng

et al. 2011

Mol Biol Rep

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Chinese sturgeon (Acipenser sinensis) is a rare and endangered species and also an important resource for the sturgeon aquaculture industry, however, a few genes have been identified in this species. We report here construction of a pituitary cDNA library from a 24 years old female Chinese sturgeon just after its spawning, and obtained 2,025 ESTs from the library. 885 unique sequences were identified, which were categorized into 12 functional groups. More than half of the unique sequences (57%) do not match with annotated sequences in the public databases. Three of these novel genes were further identified. Notably, a full-length of cDNA (1,143 bp) encoding somatolactin of 232 amino acids was identified. Phylogenetic analysis showed 97% amino acid identity with White sturgeon somatolactin. RT-PCR analysis indicated that the somatolactin mRNA was only detected in pituitary. Pituitary-specific expression of the somatolactin suggested that the protein may play important physiological functions in pituitary-endocrine system of the Chinese sturgeon.

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Section: Discussionmentioning

confidence: 99%

EST dataset of pituitary and identification of somatolactin and novel genes in Chinese sturgeon, Acipenser sinensis

Cao

Leng

et al. 2011

Mol Biol Rep

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“…However, studies of seasonal changes in SL mRNA showed the gradual stimulation of SL synthesis and release during sexual maturation, and spawning females tend to have more SL cells than equivalent males, indicating that SL may play a role in the control of some steps of reproduction (Planas et al 1992, Oliverau & Rand-Weaver 1994. Plasma SL concentrations were found to remain relatively constant throughout gonad development but were found to drop during or following ovulation in sole and halibut (Schneider 1996).…”

Section: Gh Slb Slamentioning

confidence: 99%

“…Plasma SL concentrations were found to remain relatively constant throughout gonad development but were found to drop during or following ovulation in sole and halibut (Schneider 1996). SL was found to stimulate gonad steroidogenesis produced by testicular fragments and ovarian follicles in vitro in coho salmon; however, this steroidogenic activity was considerably less than that of GH (Planas et al 1992). SL synthesis and release were found to be inhibited by gonadectomy (Specker & Sullivan 1994).…”

Section: Gh Slb Slamentioning

confidence: 99%

“…Two isoforms of SL, SLa and SLb, have been identified in zebrafish (Zhu et al 2004) and grass carp (Jiang et al 2008), and phylogenetic analyses suggest that they are paralogs that result from an ancient duplication of SL genes in ray-finned fish probably related to reproduction (Planas et al 1992, Chen et al 1994, Yang & Chen 2003. The tertiary structures of these two SLs may be different because there is an extra third cysteine in SLa, and they share only 60% sequence identity within the same species (Jiang et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…The main physiological function of the SL gene remains a matter of debate, but it is likely that SL is involved in multiple and even overlapping functions with other members of the GH/PRL family. Recent studies suggest that SLs are involved in steroidogenesis and reproductive maturation (Planas et al 1992, Olivereau & Rand-Weaver 1994, Johnson et al 1997, acid-base balance (Kakizawa et al 1996), background adaptation (Kakizawa et al 1995, Zhu & Thomas 1995, immune function (Calduch-Giner et al 1998), energy mobilization and stress (Rand-Weaver et al 1993), lipid metabolism and pigmentation (Zhu & Thomas 1997, Fukamachi et al 2004, and the regulation of chromatophores (Zhu & Thomas 1995. The recent discovery of an SL-deficient mutant in medaka (Oryzias latipes) (color interfere, ci) indicated that SL might function in the proliferation and morphogenesis of epidermal chromatophores, body color regulation, or cortisol secretion in vivo (Fukamachi et al 2005(Fukamachi et al , 2006(Fukamachi et al , 2009.…”

Section: Introductionmentioning

confidence: 99%

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A study of somatolactin actions by ectopic expression in transgenic zebrafish larvae

Wan¹,

Chan²

2010

Journal of Molecular Endocrinology

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Somatolactin (SL) is a fish-specific hormone that belongs to the prolactin (PRL) and GH family. Recently, two forms of SL, SLa and SLb, have been found in some species, and may have different actions and functions. To investigate the role of SL in fish growth and metabolism, we generated transgenic fish founders with ectopic expression of SLa and SLb to study the physiological functions and actions of these SLs among several marker genes. We fused the cDNAs encoding the precursor SLs in frame to a zebrafish b-actin gene promoter to generate transgenic zebrafish lines that were coinjected with a green fluorescent protein (GFP) driven by the same promoter. The transgenic zebrafish were selected based on GFP expression and confirmed by genomic PCR, Southern blot analysis, and transgene expression. Investigations into the expression of marker genes in larvae on different pathways using real-time PCR have provided a general understanding of the actions of SLs. This study found that the overexpression of SLa and SLb in vivo significantly enhanced the transcription of IGFs, insulin, leptin, sterol regulatory element binding protein 1, and fatty acid synthase, as well as the expression level of vitellogenin and proopiomelanocortin, while causing reduced levels of catalase and glutathione S-transferase in the larvae of transgenic zebrafish.

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Immunocytochemical and histological studies on the hypophyseal-gonadal system in the freshwater Nile Tilapia,Oreochromis niloticus (L.), during sexual maturation and spawning in different habitats

Mousa

1999

J. Exp. Zool.

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Somatolactin stimulates in vitro gonadal steroidogenesis in coho salmon, Oncorhynchus kisutch

Cited by 114 publications

References 12 publications

EST dataset of pituitary and identification of somatolactin and novel genes in Chinese sturgeon, Acipenser sinensis

EST dataset of pituitary and identification of somatolactin and novel genes in Chinese sturgeon, Acipenser sinensis

A study of somatolactin actions by ectopic expression in transgenic zebrafish larvae

Immunocytochemical and histological studies on the hypophyseal-gonadal system in the freshwater Nile Tilapia,Oreochromis niloticus (L.), during sexual maturation and spawning in different habitats

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