Somatomedin-C/IGF-I, Insulin and Prolactin Levels in Ullrich-Turner's Syndrome

Abstract

To clarify the pathogenesis of growth retardation in patients with Ullrich-Turner's syndrome (TS) we have investigated basal SmC/IGF-I, insulin and prolactin concentrations. Compared with 56 age matched healthy controls basal SmC/IGF-I concentration in 51 patients with TS older than 9-11 years was significantly lower (age group 13-14 years; TS 273 +/- 47 and controls 479 +/- 114 ng/ml). Mean basal prolactin level in 43 patients with TS (406 +/- 211 microU/ml) was significantly higher (p less than 0.01) than in 192 female controls (age 3-11 years; 264 +/- 176 microU/ml). Basal insulin concentration in 28 TS patients in comparison to 20 healthy children of a control group was significant higher (TS 18 +/- 8 microU/ml; controls 9 +/- 4 microU/ml; p less than 0.01). It seems that neither insulin nor prolactin are relevant stimulators of Smc/IGF-I in man, especially in patients with gonadal dysgenesis. Considering these results we speculate that despite higher prolactin and higher insulin levels in TS, the lower SmC/IGF-I concentrations may be predominantly related to the abnormal sex steroid secretion.

The effect of sex hormones on bone metabolism of the otic capsule – an overview

“…Interestingly, in a group of 43 patients with Turner's Syndrome the mean basal prolactin level was reported to be significantly higher than a group of 192 female controls (Amendt et al, 1992). One recent study investigated OPG and RANKL concentrations in children with different pathologies.…”

Origin of the X-chromosome influences the development and treatment outcomes of Turner syndrome

“…Notably, IGF-I has been considered a marker of growth response ( Darendeliler et al, 2007 ). Moreover, some laboratory indicators are potentially relevant to TS, e.g ., prolactin, as implied by previous reports; hence, we included several candidate factors in laboratory analysis ( Amendt, Hesse & Rohde, 1992 ; Salvarci & Zamani, 2018 ; Yeh et al, 2017 ). In the present study, we performed a follow-up survey, mainly focusing on changes in height, body weight, IGF-1, IGFBP-3, and bone age.…”