Somatosensory temporal discrimination remains intact in tension-type headache whereas it is disrupted in migraine attacks

Vurallı, Doğa; Boran, H. Evren; Çengiz, Bülent; Coşkun, Özlem; Bolay, Hayrünnisa

doi:10.1177/0333102416677050

Cited by 34 publications

(31 citation statements)

References 25 publications

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“…Considering these results, interictal impairment is proposed to be originated from thalamocortical dysfunction and altered cortical pre‐activation level . On the other hand, 2‐3 times increase in STD thresholds ictally in migraine without aura patients indicates that other mechanisms may play a role during the attack . Migraine attack associated prolongation in temporal discrimination of 2 separate somatosensory stimuli could arise from a transient impairment in the central sensory and cognitive processing …”

Section: Discussionmentioning

confidence: 99%

“…35,36 On the other hand, 2-3 times increase in STD thresholds ictally in migraine without aura patients indicates that other mechanisms may play a role during the attack. [21][22][23] Migraine attack associated prolongation in temporal discrimination of 2 separate somatosensory stimuli could arise from a transient impairment in the central sensory and cognitive processing. [21][22][23] HFOs are low-amplitude, 500-800 Hz wavelets which superimpose on the N20 component of lowfrequency somatosensory evoked potentials (SEP).…”

Section: Discussionmentioning

confidence: 99%

“…A priori statistical power analysis was not conducted. The sample size was based on our previous experience and prior migraine TMS studies . This was the primary analysis of these data.…”

Section: Methodsmentioning

confidence: 99%

“…The sample size was based on our previous experience and prior migraine TMS studies. 10,13,21,22 This was the primary analysis of these data. Since groups were small in number, clinical and neurophysiological data between all 4 groups were analyzed by Kruskal-Wallis test and if there was a significant difference, data between 2 independent groups were analyzed using Mann-Whitney U-test.…”

Section: Transcranial Magnetic Stimulation and Short-latency Afferentmentioning

confidence: 99%

“…5,17 Also reduced SAI was found in cognitive disorders presenting with cholinergic dysfunction such as Alzheimer dementia, mild cognitive impairment, and Parkinson's disease with dementia. [18][19][20] Recently, we revealed that somatosensory temporal discrimination (STD) impaired during migraine without aura attacks [21][22][23] but not in tensiontype headache 22 and concluded that disruption in sensory information processing could be specific to migraine headache. Based on these findings, we hypothesized that sensorimotor integration and the inhibitory circuit might also be disturbed during a migraine attack, and in order to test this hypothesis, we evaluated SAI in migraine without aura patients.…”

Section: Introductionmentioning

confidence: 99%

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Reduced Short‐Latency Afferent Inhibition Indicates Impaired Sensorimotor Integrity During Migraine Attacks

et al. 2019

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Background and Objective Migraine attacks disrupt sensory information processing and may also disturb sensorimotor integration. This prospective pilot study aimed to assess the sensorimotor integration and inhibitory circuitry in the sensorimotor cortex using short‐latency afferent inhibition (SAI) paradigm in migraine. Methods Twenty‐five migraine without aura patients (10 interictal, 5 preictal, 10 ictal) and 16 healthy controls were enrolled. SAI was elicited by combining the right median nerve electrical stimulation and left motor cortical magnetic stimulation at the 21‐millisecond interval. Mean motor evoked potential (MEP) amplitude ratio, recorded from right abductor pollicis muscle after single and conditioned stimulations, was calculated as SAI. Results Average MEP inhibition ratio after single and conditioned stimuli in healthy controls was not significantly different from interictal patients (45.1% ± 20.3% vs 44.5% ± 14.75% [P = .93]). However, SAI was significantly reduced during preictal/prodromal (−14.6% ± 42.8% [P = .002]) and ictal/headache (−7.4% ± 31.1% [P = .0001]) periods of migraine compared to healthy controls. Conclusion Pronounced decrease in SAI during preictal and ictal periods in migraine was shown for the first time. Instead of inhibition to a conditioned stimulus, facilitation in the sensorimotor cortex was detected both ictally and preictally. Preictal SAI results suggest the presence of increased excitability state several hours prior to the headache phase. This phenomenon could be related to the cortical hyperresponsivity to sensory stimuli and cognitive disturbances accompanying migraine attacks as SAI is modulated by cholinergic activity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…A priori statistical power analysis was not conducted. The sample size was based on our previous experience and prior migraine TMS studies . This was the primary analysis of these data.…”

Section: Methodsmentioning

confidence: 99%

Section: Transcranial Magnetic Stimulation and Short-latency Afferentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reduced Short‐Latency Afferent Inhibition Indicates Impaired Sensorimotor Integrity During Migraine Attacks

et al. 2019

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Somatosensory Temporal Discrimination in Autism Spectrum Disorder

et al. 2021

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Sensory differences are common in Autism Spectrum Disorder (ASD). While there is no well‐accepted method to measure sensory differences objectively, there is accumulating evidence from recent years concerning sensory perception, including data concerning temporal discrimination thresholds of individuals with ASD as measured by different measures. The somatosensory temporal discrimination (STD) test measures the threshold at which an individual can temporally discriminate multiple tactile stimuli delivered in succession. We aimed to investigate tactile perception in ASD and hypothesized that children with ASD have impaired STD related to their subjective sensory symptoms and daily difficulties. Thirty adolescents with ASD and 30 typically developed subjects were recruited. The Childhood Autism Rating Scale, Strengths and Difficulties Questionnaire, and Adolescent/Adult Sensory Profile were implemented before STD evaluation. Average somatosensory detection (1.48 ± 0.42) and discrimination thresholds (112.70 ± 43.45) of the children with ASD were significantly higher (P = 0.010, P = 0.001, respectively) than those of the controls (1.18 ± 0.42, 79.95 ± 31.60, respectively). Sensory seeking scores of the ASD group (40.8 ± 7.60) were significantly lower (P = 0.024) than those of the control group (45.83 ± 9.17). However, the psychophsycal thresholds did not have any statistically significant relationships with subjective sensory symptoms or daily difficulties. This study demonstrates impaired sensory processing in ASD evaluated by STD and its lack of relationship with subjective sensory symptoms and daily difficulties. This psychophysical evidence of increased STD thresholds and decreased sensory seeking profile supports the disturbances in the regulation of sensory processing in ASD. Lay Summary Sensory differences are common in autism; however, there is no well‐accepted method to measure them objectively. This study aims to investigate somatosensory differences and their relation with sensory and emotional/behavioral difficulties of children with autism. We show that autistic children have higher tactile discrimination thresholds and fewer sensory seeking behaviors. This supports the presence of impairments in sensory processing in autism. Measuring the sensory differences may help understanding clinical symptoms and neurobiological underpinings of autism. Autism Res 2021, 14: 656–667. © 2021 International Society for Autism Research and Wiley Periodicals LLC

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