Somatostatin Receptor Expression Is Associated With Metastasis and Patient Outcome in Pulmonary Carcinoid Tumors

Abstract

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A Novel Gene Signature-Based Model Predicts Biochemical Recurrence-Free Survival in Prostate Cancer Patients after Radical Prostatectomy

“…For instance, ASNS, one risk biomarker in our study, was reported to function as a therapeutic target in castration-resistant prostate cancer [27]. SSTR1 was widely related to the progression of various cancers [28][29][30], and also functions as a prognostic marker in prostate cancer [31,32]. TRIM14 has been reported to promote invasion in glioblastoma [33] and colorectal cancer [34].…”

Development and Validation of an Individualized Nomogram for Predicting Overall Survival in Patients With Typical Lung Carcinoid Tumors

“… 35 The expression of somatostatin receptors has also been found to be associated with prognosis in patients with pulmonary carcinoids. 36 Further studies taking Ki-67% and somatostatin receptors into account will need to be undertaken to construct more predictive nomograms. In addition, further research could also be conducted to determine whether our nomogram can be applicable to other patient cohorts.…”

Somatostatin receptor expression in parathyroid neoplasms

“…Table 2 summarizes information on the antibodies used as well as the staining details. These antibodies have previously been used by our research group also including negative controls (23), and their specificity have been confirmed by Western blot and in vitro receptor autoradiography (24, 25, 26, 27, 28). Antibody binding was visualized using the polymer-based OptiView and UltraView Universal DAB Detection Kit (Ventana Medical System, Inc., Tucson, AZ, USA) or the EnVision Detection Systems (Dako, Agilent Pathology Solutions).…”

“…The antibodies used in our study have been previously used and verified (25, 26, 27, 28, 33) with Western blotting and/or in vitro somatostatin receptor autoradiography. The same antibodies have previously been used by our research group for a study on pulmonary carcinoid tumors (23) as well as pheochromocytomas and paragangliomas (antibodies for SST 2 -SST 4 (34)). We stained control tissue (pancreas and small intestine) to serve as a test for the functionality of the staining protocol as well as internal negative control.…”