Some Aminodibenzothiophenes

A Promising PET Tracer for Imaging of α7 Nicotinic Acetylcholine Receptors in the Brain: Design, Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand

“…Isolation of compound 3 from the 3,7-dibrominated by-product (not shown) along with unreacted starting material was obtained by fractional crystallization of the dibromo compound, followed by a chromatographic separation of pure 3 from the filtrate. The 2-nitrodibenzothiophene sulfone 5a was prepared by nitration of 1a using HNO 3 (65%) in acetic acid [30,31] affording the 2-nitro compound 4a in moderate yield (26%), followed by oxidation with H 2 O 2 in acetic acid to give 5a [32]. The 2-nitro-7-bromo-dibenzothiophene sulfone 6a was obtained by bromination of 5a according to the corresponding conversion of 2 to 3 .…”

“…Reagents and solvents were purchased from commercial sources and used without further purification unless otherwise noted. Compounds 2 , 4a , and 5a were prepared starting from 1a (dibenzo[ b , d ]thiophene; Acros Organics, Geel, Belgium) according to literature methods [30,31,32]. The preparation of intermediates 3 , 5b , 8a , 8b , and the final compound 10 have been described previously, but with different synthetic routes or from starting materials not used in our protocols [17,31,62].…”

“…Compounds 2 , 4a , and 5a were prepared starting from 1a (dibenzo[ b , d ]thiophene; Acros Organics, Geel, Belgium) according to literature methods [30,31,32]. The preparation of intermediates 3 , 5b , 8a , 8b , and the final compound 10 have been described previously, but with different synthetic routes or from starting materials not used in our protocols [17,31,62]. Intermediate 6a (two steps from 4a ), 6b (one step from 5b ) and final compounds 10a , 10b , 11a and 11b (one step each, from amine 9a ), which have been prepared according to the literature [62], were also reported by Gao et al [17].…”

Hamiltonian and Boundary Conditions for Electrons in Semiconductor Heterostructures

“…Note that for internal voltage values greater than 0.3 V the transport process is determined by the transfer of valence band electrons from the barrier region into the conduction band of the InAs electrode. This effect is additionally accounted for in our calculations using a technique similar to that presented in [33]. But more interesting is the range Uint < 0.3 V where the elastic tunneling process dominates.…”

One-Pot Synthesis of Aminated Benzo-Fused Heterocycles and N-Substituted Dibenzothiophenes via Copper-Catalyzed Ullmann Type Reaction

“…For example, Gilman reported the synthesis of 2-aminodibenzothiophene through the synthesis of nitroarene, followed by reduction using Raney nickel as a catalyst. 3 Additionally, 2-aminodibenzothiophene and 2-aminodibenzofuran were synthesized through electrophilic amination, however, it required the synthesis of the organometallic starting material aryl lithium. 4 Recently, Uchida's group synthesized primary amines of dibenzothiophene, dibenzofuran, and carbazole through the synthesis of the starting material acetyl arenes.…”