Some aspects of liver disease in Ugandan Africans

Hutt, M. S. R.

doi:10.1016/0035-9203(71)90001-0

Cited by 18 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Strongyloides stercoralis as a cause of granulomatous hepatitis was not mentioned by Guckian and Perry (1966) in their review of this disease, nor did Hutt (1971) observe this parasite in Uganda when reporting on a large series of liver biopsies. However, occasional hepatic granulomata caused by S. S. larvae have been described as incidental post-mortem findings.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Granulomatous hepatitis due to Strongyloides stercoralis

Poltera

Katsimbura

1974

The Journal of Pathology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

“…

PLATES CXXXVII-CXL THE histopathology of liver disease in Ugandan Africans has been described by Hutt (1971), who found that the commonest liver granulomata were due to Schistosoma mansoni or tuberculosis and rarely to leprosy. Occasionally, he also observed necrotising granulomata for which, in spite of careful searching, no aetiological agent was found.

…”

mentioning

confidence: 99%

Granulomatous hepatitis due to Strongyloides stercoralis

Poltera

Katsimbura

1974

The Journal of Pathology

View full text Add to dashboard Cite

“…In addition, fatty change is also present (haematoxylin-eosin x 300). commented upon (Hutt, 1971). As illustrated in fig 1 these consist of slight nuclear variability, the presence of occasional double nuclei, and an increase in the number of Kupffer cells.…”

Section: Definition Of Liver Cell Dysplasiamentioning

confidence: 88%

Liver cell dysplasia: a premalignant condition

Anthony¹,

Vogel²,

Barker³

1973

J Clin Pathol

326

127

View full text Add to dashboard Cite

Liver cell dysplasia is defined as cellular enlargement, nuclear pleomorphism, and multinucleation of liver cells occurring in groups or occupying whole cirrhotic nodules. The prevalence, natural history, and relationship to the Australia or hepatitis-associated antigen (HAA) have been studied in 552 Ugandan African patients with normal, cirrhotic, and cancerous livers. Liver cell dysplasia was found in only two of 200 (1%) patients with normal livers, in three of 43 (6.9%) of patients with normal livers bearing primary liver cell carcinoma, 35 of 175 (20.3%) patients with cirrhosis, and 80 of 124 (64.5%) of patients with cirrhosis and primary liver cell carcinoma. Cirrhotic patients without dysplasia were, on average, ten years younger than those with dysplasia and the latter were on average six years younger than those with cirrhosis and carcinoma. Liver cell dysplasia occurred more frequently in males than in females. It was found in all but one instance in macronodular or mixed forms of cirrhosis only. There was a strong relationship between dysplasia and the presence of HAA in 104 patients that suggests a possible carcinogenic mechanism for the longincubation (serum or B) hepatitis virus in liver cell carcinoma. It is concluded that the presence of liver cell dysplasia identifies a group of patients with a high risk of liver cell carcinoma and that they should be followed up by serial alpha-fetoprotein estimations.

show abstract

“…In Mulago hospital, tuberculosis accounted for more than lo?/, of the admissions in 1980. T h e National Tuberculosis Control Program (NTCP) has addressed the problem nationwide, contrary to earlier reports by Hutts (3).…”

Section: T H E D I S E a S E P A T T E R Nmentioning

confidence: 86%

“…In spite of vaccination programmes, health education, the availability of economic and effective chemotherapeutic drugs, tuberculosis remains one of the major paediatric problems in Africa and other tropical countries (2). It is probably the most common cause of death in young adults in Uganda (3). In Mulago hospital, tuberculosis accounted for more than lo?/, of the admissions in 1980.…”

Section: T H E D I S E a S E P A T T E R Nmentioning

confidence: 99%

An Overview of the Use of Anti-Tuberculous Drugs in Uganda and Hong Kong

1991

View full text Add to dashboard Cite

Anti-tuberculous (Anti-TB) chemotherapy in Uganda is outlined. Its pattern of use and the subsequent shortcomings have prompted the need for the present review. A collateral comparison to that of Hong Kong was run to emphasize the correlation of anti-TB chemotherapy with economic development and regional variation in the population of the two areas. Tuberculosis of the central nervous system (CNS) has a high fatality rate. In the search for a more comprehensive anti-TB dosage regimen, the difficulty in treating tuberculosis of the CNS has attracted special attention with emphasis on the fate of anti-TB drugs across the meninges. The choice of a method for drug analysis in routine therapeutic drug monitoring for a country is likewise determined by factors similar to those for the anti-TB regimen. Uganda needs an inexpensive, precise and selective method for TB treatment tailored to its financial and manpower resources.

show abstract

Some aspects of liver disease in Ugandan Africans

Cited by 18 publications

References 16 publications

Granulomatous hepatitis due to Strongyloides stercoralis

Granulomatous hepatitis due to Strongyloides stercoralis

Liver cell dysplasia: a premalignant condition

An Overview of the Use of Anti-Tuberculous Drugs in Uganda and Hong Kong

Contact Info

Product

Resources

About