Some aspects of the effects of clobazam on human psychomotor performance.

Abstract

1Three studies are described, the first being a comparison of the effects of acute night-time doses of clobazam 20 mg, amylobarbitone sodium 100 mg, nitrazepam 5 mg and placebo, on choice reaction time, critical flicker fusion (CFF) and stabilometer performance. Clobazam improved early morning performance on a choice reaction test, in contrast to the other two active drugs. 2 Repeated doses of clobazam 10 mg three times daily, chlordiazepoxide 10 mg three times daily and diazepam 5 mg three times daily were given for 5 days. Again clobazam did not produce any impairment of psychomotor performance, and noticeably increased CFF thresholds. 3 The effects of an acute night-time dose of clobazam 20 mg on psychomotor performance the morning after night-time medication were correlated with the neuroticism scores (on the EPI) of the subjects. Clobazam exerts a differential effect on psychomotor performance dependent on the basic personality trait. 4 Clobazam seems to differ significantly from the 1,4-benzodiazepines in that, although it reduces anxiety, it does so without any apparent impairment of psychomotor performance.

Respiratory and sedative effects of clobazam and clonazepam in volunteers.

“…Thirty stimuli were presented. The critical flicker fusion threshold (CFFT) (Hindmarch, 1979) Ventilatory response to C02 The ventilatory response to CO2 was measured using a Bell closed circuit spirometer (Ealing). The soda lime canister was removed from the spirometer circuit and the cylinder filled with 5% CO2 in oxygen.…”

“…There are numerous reports in the literature concerning the effects of these drugs individually and in comparison with other benzodiazepines (Gudgeon & Hickey, 1981;Hindmarch, 1979). Cull & Trimble (1985) compared the two agents in volunteers, but the same subjects did not receive both clonazepam and clobazam.…”

The effect of clobazam and lorazepam on the psychomotor performance of anxious patients.

“…The following tests were applied: (a) Hamilton anxiety scale (HAS) (Hamilton, 1959) (b) Digit symbol substitution test (DSST) (Matarazzo, 1972) (c) Purdue pegboard tests (PPT) using preferred hand, both hands and assembly tasks (Tiffin, 1968) (d) Choice reaction time (CRT) (Hindmarch, 1979) (e) Critical flicker fusion threshold (CEFT) (Hindmarch, 1979) (f) Inglis paired-associate learning test (IPALT) (Inglis, 1959).…”

Pharmacodynamic effects of buspirone and clobazam.

“…Clobazam, a 1,5-benzodiazepine, is structurally different from the 1,4-benzodiazepines and also lacks many of the characteristic sedative and amnestic side effects. Psychomotor and cognitive performance measures, including memory, have remained unimpaired with acute doses of clobazam up to and including 30 mg (Hindmarch, 1979(Hindmarch, , 1982a(Hindmarch, , 1985Wittenborn et al, 1979). Clobazam could not be distinguished from placebo in a repeated dose study comparing clobazam 10 mg three times daily on measures of driving performance, whilst lorazepam was significantly worse .…”