Some aspects relating to the evaluation of the effects of chemicals on male fertility

Mangelsdorf, Inge; Buschmann, J.; Orthen, Bruno

doi:10.1016/s0273-2300(03)00026-6

Cited by 90 publications

(51 citation statements)

References 58 publications

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“…Sperm motility is an important parameter to evaluate sperm quality and fertilizing potential [41]. The present study showed a decrease in the motility of sperm from adult males following flutamide-treatment.…”

Section: Tablesupporting

confidence: 53%

“…However, this is most likely attributed to the lack of sensitivity afforded by natural mating animals with inherently robust sperm production and sperm quality [20,40]. For example, male rats and rabbits fertilize successfully even when 90% of their sperm reserves are depleted [41]. Artificial insemination has been used successfully as a strategy to evaluate sperm quality following toxicant exposure [20,42].…”

Section: Tablementioning

confidence: 99%

See 1 more Smart Citation

Impairment on sperm quality and fertility of adult rats after antiandrogen exposure during prepuberty

Perobelli

Alves

Toledo

et al. 2012

Reproductive Toxicology

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Section: Tablesupporting

confidence: 53%

Section: Tablementioning

confidence: 99%

Impairment on sperm quality and fertility of adult rats after antiandrogen exposure during prepuberty

Perobelli

Alves

Toledo

et al. 2012

Reproductive Toxicology

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“…The standard method for determining adverse effects of chemical compounds on fertility in animal experiments is based on mating trials to determine number of pregnant females and litter size (Mangelsdorf et al, 2003). In the present study, the fertility (%) and litter size declined in a dose dependent manner.…”

Section: Discussionmentioning

confidence: 59%

Assessment of Molybdenum Induced Alteration in Oxidative Indices, Biochemical Parameters and Sperm Quality in Testis of Wistar Male Rats

Pandey¹,

Jain²

2015

Asian J. of Biochemistry

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The present study was carried out to investigate the effects of ammonium molybdate on lipid peroxidation, antioxidant, biochemical and semen parameters in male Wistar rats. Group I served as control while group II, III and IV received 50, 100 and 150 mg kgG for 60 days and thereafter left for recovery study for 60 days. The present study examined the effects of ammonium molybdate on serum testosterone, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) along with sperm parameters. Estimations were also made for marker biochemical and antioxidant parameters in testis. Ammonium molybdate treatment resulted in a dose dependent reduction in serum testosterone, FSH, LH, sperm count, motility and viability. The concentration of total protein and sialic acid as well as activities of acid phosphatase (ACP) and alkaline phosphatase (ALP) were decreased in a dose dependent manner while there was a significant increase in the glycogen and cholesterol level in testis. The level of Thiobarbituric Acid Reactive substance (TBARs) was increased while the activities of superoxide dismutase and concentration of glutathione and ascorboic acid was decreased significantly in testis of rats treated with ammonium molybdate. All the parameters showed significant improvement after 60 days of treatment withdrawal in highest dose group. The findings suggested that ammonium molybdate exerts a deleterious effect on testicular function by altering biochemical and antioxidant status of the testes.

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“…The disruption of spermatogenesis in men (Table 1) at any stage of cell differentiation can decrease the total sperm count, increase the abnormal sperm count, impair the stability of sperm chromatin or damage sperm DNA (43). Accumulating in the epididimys, prostate, vesicular seminalis or seminal fl uid, metals may impair progressive sperm motility (44).…”

Section: Targets and Mechanisms Of Metal Actionmentioning

confidence: 99%

Reproductive Toxicity of Metals in Men

Pizent¹,

Tariba²,

Živković³

2012

Archives of Industrial Hygiene and Toxicology

108

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A combination of genetic, environmental and lifestyle factors contributes to adverse effects on the reproductive health in men. Metals are pervasive in food, water, air, tobacco smoke, and alcoholic beverages. Experimental studies suggest that many metals have adverse effects on the male reproductive function. However, information about reproductive effects of human exposure to metals is scarce and/or inconsistent. This review summarises the information from epidemiological studies of the effects of metal exposure on reproductive function in men. Factors capable of affecting these relationships were identifi ed and discussed. A particular attention is given to the studies considering infl uence of concomitant exposure to various metals. These studies have generally confi rmed that even moderate-to low-level exposure to lead affects certain reproductive parameters, and that exposure to cadmium affects the prostate function and serum testosterone levels. Adverse effects of mercury, manganese, chromium and arsenic on semen quality and altered serum hormone are less well documented. There is no clear evidence that boron exposure may impair reproductive health in men. Only a few studies have investigated reproductive effects of concomitant exposure to several metals and controlled for potential confounders. Future studies should consider the contribution of combined exposure to various metals and/or other factors that may infl uence individual susceptibility to reproductive health impairment in men. KEY WORDS: human semen quality, metals, metalloids, metal interactions, sex hormonesPizent A, et al.

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Some aspects relating to the evaluation of the effects of chemicals on male fertility

Cited by 90 publications

References 58 publications

Impairment on sperm quality and fertility of adult rats after antiandrogen exposure during prepuberty

Impairment on sperm quality and fertility of adult rats after antiandrogen exposure during prepuberty

Assessment of Molybdenum Induced Alteration in Oxidative Indices, Biochemical Parameters and Sperm Quality in Testis of Wistar Male Rats

Reproductive Toxicity of Metals in Men

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