Some Cardiovascular Effects of Phenyl-2-Butyl-Norsuprifen Hydrochloride (Arlidin)

Fs, Caliva; Eich, Robert H.; Hl, Taylor; Rh, Lyons

doi:10.1097/00000441-195908000-00006

Cited by 11 publications

(2 citation statements)

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“…Heretofore, knowledge of the hemodynamic effects of this agent in the normal subject has been limited to the 2 individuals described by Caliva and his co-workers. 1 Until adequate studies are reported, detailing the normal physiologic responses of pharmacologic agents, further clinical application of such drugs is limited to the experiences in various pathologic states. The data described herein suggest that an agent such as nylidrin may be of value in disease states other than peripheral arterial insufficiency associated with intermittent claudication.…”

Section: Discussionmentioning

confidence: 99%

Local and systemic hemodynamic effects of nylidrin

Fröhlich

Schnaper

1964

Clin Pharma and Therapeutics

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The hemodynamic effects of nylidrin were observed in a group of normal human subjects and in the constantly perfused dog forelimb. In the human, heart rate and cardiac output increased following acute intra‐arterial administration of the drug; total peripheral resistance, mean circulation time, and arterial blood pressure decreased. The plasma and central blood volumes and hematocrit remained unchanged, whereas blood volume decreased; stroke volume and venous pressure showed no consistent change. In the dog forelimb, acute local elevation of plasma nylidrin concentration greatly decreased resistance to blood flow in the small vessels over a wide dose range. It appears that there are two primary effects of this agent following its intra‐arterial administration: one, to decrease total peripheral resistance; and two, a direct effect on the heart to increase cardiac output. In the dosage used and the route administered, there were no clinically significant effects on heart rate or blood pressure. These results suggest that nylidrin exerts these local vascular and myocardial actions by stimulation of the beta‐adrenergic receptor sites.

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Section: Discussionmentioning

confidence: 99%

Local and systemic hemodynamic effects of nylidrin

Fröhlich

Schnaper

1964

Clin Pharma and Therapeutics

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“…It produces a marked effect on cardiac output, respiration, and peripheral resistance, mimicking the effects of beta adrenergic stimulation (Ahlquist, 1948) as produced by isoprenaline. Various authors have noted its selectively greater dilator effect in resting muscle compared to skin areas (Caliva, Eich, Taylor, and Lyons, 1959;Winsor, Hyman, and Knapp, 1960). It thus seemed to be worth investigating it further.…”

Section: Newer Vasodilators and Intermittent Claudicationmentioning

confidence: 99%